Opto Field-Effect Transistors for Detecting Quercetin–Cu2+ Complex

Abstract

In this study, we explored the potential of applying biosensors based on silicon nanowire field-effect transistors (bio–NWFETs) as molecular absorption sensors. Using quercetin and Copper (Cu2+) ion as an example, we demonstrated the use of an opto–FET approach for the detection of molecular interactions. We found that photons with wavelengths of 450 nm were absorbed by the molecular complex, with the absorbance level depending on the Cu2+ concentration. Quantitative detection of the molecular absorption of metal complexes was performed for Cu2+ concentrations ranging between 0.1 μM and 100 μM, in which the photon response increased linearly with the copper concentration under optimized bias parameters. Our opto–FET approach showed an improved absorbance compared with that of a commercial ultraviolet-visible spectrophotometry.

Advanced Field-Effect Sensors

“…The detection of metal ions is an important need as metal ions are essential to the human body and play an important role in human health. Budhi Laksana and coworkers investigate a biosensor using quercetin and copper (Cu 2+ ) ions as molecules for detecting the molecular absorption of metal complexes [20]. The proposed biosensor consists of a silicon nanowire FET (bio-NWFET) platform able to detect various concentrations of copper based on quercetin-metal ion interactions.…”