Opto-Microfluidic Immunosensors: From Colorimetric to Plasmonic

He, Jijun; Wang, Da-Shin; Fan, Shih-Kang

doi:10.3390/mi7020029

Cited by 17 publications

(9 citation statements)

References 122 publications

(136 reference statements)

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“…Reliable, rugged microfluidic systems for rapid and precise measurements on small sample volumes [10], without an expert operator [51], make it possible to develop chip-scale microfluidic PoC devices for highly precise laboratory operations. The various approaches and challenges for this aim using optical, electrochemical, and nanomaterials are reviewed in recent papers [6,52,53]. We will focus here on the most recent developments, in particular during the last two years.…”

Section: Microfluidic Point-of-care Devicesmentioning

confidence: 99%

Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics

Mejía‐Salazar

Cruz

Vásques

et al. 2020

Sensors

145

111

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Point-of-care (PoC) diagnostics is promising for early detection of a number of diseases, including cancer, diabetes, and cardiovascular diseases, in addition to serving for monitoring health conditions. To be efficient and cost-effective, portable PoC devices are made with microfluidic technologies, with which laboratory analysis can be made with small-volume samples. Recent years have witnessed considerable progress in this area with “epidermal electronics”, including miniaturized wearable diagnosis devices. These wearable devices allow for continuous real-time transmission of biological data to the Internet for further processing and transformation into clinical knowledge. Other approaches include bluetooth and WiFi technology for data transmission from portable (non-wearable) diagnosis devices to cellphones or computers, and then to the Internet for communication with centralized healthcare structures. There are, however, considerable challenges to be faced before PoC devices become routine in the clinical practice. For instance, the implementation of this technology requires integration of detection components with other fluid regulatory elements at the microscale, where fluid-flow properties become increasingly controlled by viscous forces rather than inertial forces. Another challenge is to develop new materials for environmentally friendly, cheap, and portable microfluidic devices. In this review paper, we first revisit the progress made in the last few years and discuss trends and strategies for the fabrication of microfluidic devices. Then, we discuss the challenges in lab-on-a-chip biosensing devices, including colorimetric sensors coupled to smartphones, plasmonic sensors, and electronic tongues. The latter ones use statistical and big data analysis for proper classification. The increasing use of big data and artificial intelligence methods is then commented upon in the context of wearable and handled biosensing platforms for the Internet of things and futuristic healthcare systems.

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Section: Microfluidic Point-of-care Devicesmentioning

confidence: 99%

Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics

Mejía‐Salazar

Cruz

Vásques

et al. 2020

Sensors

145

111

View full text Add to dashboard Cite

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“…Readers who are interested in this topic can find additional details in other specific reviews. 81 − 84 …”

Section: Surface Modification Strategiesmentioning

confidence: 99%

Chemical Functionalization of Plasmonic Surface Biosensors: A Tutorial Review on Issues, Strategies, and Costs

Oliverio

Perotto

Messina

et al. 2017

ACS Appl. Mater. Interfaces

157

132

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In an ideal plasmonic surface sensor, the bioactive area, where analytes are recognized by specific biomolecules, is surrounded by an area that is generally composed of a different material. The latter, often the surface of the supporting chip, is generally hard to be selectively functionalized, with respect to the active area. As a result, cross talks between the active area and the surrounding one may occur. In designing a plasmonic sensor, various issues must be addressed: the specificity of analyte recognition, the orientation of the immobilized biomolecule that acts as the analyte receptor, and the selectivity of surface coverage. The objective of this tutorial review is to introduce the main rational tools required for a correct and complete approach to chemically functionalize plasmonic surface biosensors. After a short introduction, the review discusses, in detail, the most common strategies for achieving effective surface functionalization. The most important issues, such as the orientation of active molecules and spatial and chemical selectivity, are considered. A list of well-defined protocols is suggested for the most common practical situations. Importantly, for the reported protocols, we also present direct comparisons in term of costs, labor demand, and risk vs benefit balance. In addition, a survey of the most used characterization techniques necessary to validate the chemical protocols is reported.

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“…Except for interpreting the energy transfer in nature, manipulating the energy transfer in artificial structures also has many potential applications. For example, white-light emitting nanofiber has been fabricated through the efficient energy transfer [3], sensitive and efficient biosensing has been realized by designing the novel nanostructures [4], efficient solar energy conversion can also be achieved by plasmonic nanostructures [5] and so on.…”

Section: Introductionmentioning

confidence: 99%

Topologically protected long-range coherent energy transfer

Wang¹,

Ren²,

Zhang³

et al. 2020

Photon. Res.

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The realization of robust coherent energy transfer with a long range from a donor to an acceptor has many important applications in the field of quantum optics. However, it is hard to be realized using conventional schemes. Here, we demonstrate theoretically that the robust energy transfer can be achieved using a photonic crystal platform, which includes the topologically protected edge state and zero-dimensional topological corner cavities. When the donor and the acceptor are put into a pair of separated topological cavities, respectively, the energy transfer between them can be fulfilled with the assistance of the topologically protected interface state. Such an energy transfer is robust against various kinds of defects, and can also occur over very long distances, which is very beneficial for biological detections, sensors, quantum information science and so on.

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Opto-Microfluidic Immunosensors: From Colorimetric to Plasmonic

Cited by 17 publications

References 122 publications

Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics

Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics

Chemical Functionalization of Plasmonic Surface Biosensors: A Tutorial Review on Issues, Strategies, and Costs

Topologically protected long-range coherent energy transfer

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