Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals

Petrov, Irene Y.; Petrov, Yuriy; Prough, Donald S.; Cicenaite, Inga; Esenaliev, Rinat O.

doi:10.1364/oe.20.004159

Cited by 47 publications

(31 citation statements)

References 23 publications

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“…For this first application, such as brain imaging with intact scalp [8], [23], due to the deep imaging depth and much stronger attenuation [∼6.9 dB/(MHz·cm)] of high-frequency components of photoacoustic signals caused by the scalp, only low-frequency signals could be survived and detected by the transducer with low frequency. High-sensitivity detection and low-signal SNR are the bottleneck of deep tissue imaging.…”

Section: Discussionmentioning

confidence: 99%

“…Then, a beam splitter and a photodiode (DET10A, Thorlabs) are used to monitor the laser intensity fluctuation. The vessel-mimicking phantom is a silicone tube (outer diameter: 3 mm, inner diameter: 2.2 mm) filled with the porcine blood pumped by a syringe, which is designed to model the brain superior sagittal sinus (SSS), human's carotid, jugular with similar vessel diameter (1 ∼ 5 mm) and measured the photoacoustic signal waveform [23], [24]. The phantom is immersed in water for optimum light transparency and acoustic coupling.…”

Section: B Experimental Setupmentioning

confidence: 99%

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Coherent Photoacoustic-Ultrasound Correlation and Imaging

Gao

Feng

Zheng

2014

IEEE Trans. Biomed. Eng.

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Both photoacoustics and ultrasound have been researched extensively but separately. In this letter, we report an initial study on the coherent correlation between pulsed photoacoustic wave and pulse-echo ultrasound wave. By illuminating an object with a pulsed laser and external ultrasound sequentially, both the endogenous photoacoustic wave and pulse-echo ultrasound wave are received and coherently correlated, demonstrating enhanced signal-to-noise ratio. Image contrast of the proposed coherent photoacoustic-ultrasound imaging is also demonstrated to be improved significantly on vessel-mimicking phantom, due to fusion of the optical absorption and ultrasound reflection contrasts by coherent correlation of either conventional laser-induced photoacoustic imaging or pulse-echo ultrasound imaging separately.

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Section: Discussionmentioning

confidence: 99%

Section: B Experimental Setupmentioning

confidence: 99%

Coherent Photoacoustic-Ultrasound Correlation and Imaging

Gao

Feng

Zheng

2014

IEEE Trans. Biomed. Eng.

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“…The system utilizes an optical parametric oscillator (OPO), the Opolette HE 532 (Opotek Inc., Carlsbad, CA), as a source of pulsed near-infrared (NIR) light in the wavelength range of 680-950 nm with a pulse width of about 6 ns and a pulse repetition rate of 20 Hz. Wide-band, highly-sensitive optoacoustic probes were developed in our laboratory for monitoring, imaging, and sensing in reflection and transmission modes [1][2][3][4][5][11][12][13][14][15][16][17][18][19][20][21][22][23] . The laser light was delivered to the probe through fiber-optic systems specially developed for the reflection and transmission modes.…”

Section: Methodsmentioning

confidence: 99%

Optoacoustic measurements of human placenta and umbilical blood oxygenation

Nanovskaya

Petrov

et al. 2016

SPIE Proceedings

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Adequate oxygenation is essential for normal embryogenesis and fetal growth. Perturbations in the intrauterine oxidative environment during pregnancy are associated with several pathophysiological disorders such as pregnancy loss, preeclampsia, and intrauterine growth restriction. We proposed to use optoacoustic technology for monitoring placental and fetal umbilical blood oxygenation. In this work, we studied optoacoustic monitoring of oxygenation in placenta and umbilical cord blood ex vivo using technique of placenta perfusion. We used a medical grade, nearinfrared, tunable, optoacoustic system developed and built for oxygenation monitoring in blood vessels and in tissues. First, we calibrated the system for cord blood oxygenation measurements by using a CO-Oximeter (gold standard). Then we performed validation in cord blood circulating through the catheters localized on the fetal side of an isolated placental lobule. Finally, the oxygenation measurements were performed in the perfused placental tissue. To increase or decrease blood oxygenation, we used infusion of a gas mixture of 95% O2 + 5% CO2 and 95% N2 + 5% CO2, respectively. In placental tissue, up to four cycles of changes in oxygenation were performed. The optoacoustically measured oxygenation in circulating cord blood and in placental lobule closely correlated with the actual oxygenation data measured by CO-Oximeter. We plan to further test the placental and cord blood oxygenation monitoring with optoacoustics in animal and clinical studies.

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“…Noninvasive measurement of other important physiologic variables 1,2 including total hemoglobin concentration can be performed as well, because infants (in particular, LBW and VLBW infants) often have abnormal levels of total hemoglobin concentration. We developed, built, and tested in animal and clinical studies optoacoustic systems for noninvasive measurement and continuous monitoring of cerebral oxygenation and other important physiologic variables [3][4][5][6][7][8][9][10][11][12][13][14] . The optoacoustic technique combines the advantages of both optical (high contrast) and ultrasound (high resolution) techniques and (using well-established difference in the absorption spectra of oxy-and deoxyhemoglobin 15 ) can be used for accurate monitoring of cerebral oxygenation and other important physiologic variables in adults, children, and infants.…”

Section: Introductionmentioning

confidence: 99%

Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

et al. 2015

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Premature, very-low-birth-weight (VLBW; ≤1500 g) and low-birth-weight (LBW; 1500-2499 g) infants are at increased risk for severe neurological disability. 25-50% of the 63,000 VLBW infants born annually in the USA have major longterm cognitive or neurobehavioral deficits in which cerebral hypoxia plays an important role. At present, no technology is capable of noninvasive, accurate monitoring of cerebral oxygenation in newborns. We proposed to use an optoacoustic technique for noninvasive cerebral hypoxia monitoring by probing the superior sagittal sinus (SSS). Recently, we developed and built a medical grade, multi-wavelength, near-infrared optoacoustic system suitable for neonatal applications. We designed and built an adjustable patient interface for neonates with VLBW, LBW, and normal weight (NBW) that provides single or continuous measurements of the SSS blood oxygenation in both the reflection and transmission modes. We performed pilot clinical tests of the system in VLBW, LBW, and NBW hemodynamically stable infants admitted to the neonatal intensive care unit. The system was capable of detecting SSS signals through the open anterior and posterior fontanelles and through the skull and allowed for monitoring of the SSS blood oxygenation in both modes. To the best of our knowledge this paper reports for the first time detection of optoacoustic signals from human cerebral blood vessels in both the transmission mode and the reflection mode. Analysis of the signals allows for noninvasive measurement of cerebral venous blood oxygenation in newborns in both modes. The transmission mode can be used for accurate measurement of the total hemoglobin concentration as well. The method and system proposed in this study can be used for optoacoustic human brain imaging, tomography, and mapping.

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Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals

Cited by 47 publications

References 23 publications

Coherent Photoacoustic-Ultrasound Correlation and Imaging

Coherent Photoacoustic-Ultrasound Correlation and Imaging

Optoacoustic measurements of human placenta and umbilical blood oxygenation

Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

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