Optofluidic label-free SERS platform for rapid bacteria detection in serum

Hunter, R. F.; Sohi, Ali Najafi; Khatoon, Zohra; Berthiaume, Vincent R.; Alarcon, Emilio I.; Godin, Michel; Anis, Hanan

doi:10.1016/j.snb.2019.126907

Cited by 43 publications

(27 citation statements)

References 33 publications

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“…By investigating the changes of SERS spectra intensity when a susceptible strain is exposed to an antibiotic, the antibiotic-induced chemical changes in bacterial cells can be analyzed. [141][142][143] The main feature of Raman spectroscopy is that it can easily provide detailed fingerprint information of various molecules in the biological system. Therefore, it has a high potential for broad applications prospect in the study of the interaction between nanoparticles and microorganisms.…”

Section: Application Of Bacterial Detection In Clinical and Food Safetymentioning

confidence: 99%

Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques

et al. 2020

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The rapid, highly sensitive, and accurate detection of bacteria is the focus of various fields, especially food safety and public health. Surface-enhanced Raman spectroscopy (SERS), with the advantages of being fast, sensitive, and nondestructive, can be used to directly obtain molecular fingerprint information, as well as for the on-line qualitative analysis of multicomponent samples. It has therefore become an effective technique for bacterial detection. Within this progress report, advances in the detection of bacteria using SERS and other compatible techniques are discussed in order to summarize its development in recent years. First, the enhancement principle and mechanism of SERS technology are briefly overviewed. The second part is devoted to a label-free strategy for the detection of bacterial cells and bacterial metabolites. In this section, important considerations that must be made to improve bacterial SERS signals are discussed. Then, the label-based SERS strategy involves the design strategy of SERS tags, the immunomagnetic separation of SERS tags, and the capture of bacteria from solution and dye-labeled SERS primers. In the third part, several novel SERS compatible technologies and applications in clinical and food safety are introduced. In the final part, the results achieved are summarized and future perspectives are proposed.

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Section: Application Of Bacterial Detection In Clinical and Food Safetymentioning

confidence: 99%

Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques

et al. 2020

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“…Dual-enhancement using MNP shell -AuNP core with vancomycin SERS tags exhibited a 3.3-fold higher sensitivity [250] than functionalised polymeric MNPs [251]. Optofluidic platforms allow ultrasensitive (LOD: 4 CFU mL −1 ) bacteria determination in a short assay time (15 min) [252]. SERS-based platforms hold enormous potential for the recognition of proteins [253][254][255][256] as well as for the identification cells [257] and genetic mutations [258].…”

Section: Reflectometric Interference Spectroscopy Biosensorsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

2020

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…Luo et al [34] detected E. coli bacteria in milk by using radial flow chromatographic immunoassay (RFCI) method using gold nanoparticles as a chromatic agent. Hunter et al [35] synthesized nanobiosensors to quickly detect pathogenic bacteria in serum with the optofluidic (surface-enhanced Raman scattering) SERS method. In this study, a hollow core photonic crystal fiber filled with microfluidics was used as the main converter.…”

Section: Purpose Of Usage Nanosensors Referencesmentioning

confidence: 99%

The Components of Functional Nanosystems and Nanostructures

Baysal¹

2020

Smart Nanosystems for Biomedicine, Optoelectronics and Catalysis

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The science of nanosystems is used in many fields such as medicine, biomedical, biotechnology, agriculture, environmental pollution control, cosmetics, optics, health, food, energy, textiles, automotive, communication technologies, agriculture, and electronics. Nanomaterials, nanostructures, and nanosystems have recently brought the most popular and innovative approaches to our lives. This new technology is based on the production of invisible particles and the production of new materials by controlling the atomic sequence of these particles. Nanotechnological studies are based on mimicking the principle of atomic sequence in nature. Using a combination of different disciplines, it finds application in almost every field of our lives. Nanospheres, nanorobots, biosensors, quantum dots, and biochips are the main components of nanoparticles. Many new diagnostic and treatment methods are being developed nano-dimensional.

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Optofluidic label-free SERS platform for rapid bacteria detection in serum

Cited by 43 publications

References 33 publications

Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques

Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques

Recent Progress in Optical Sensors for Biomedical Diagnostics

The Components of Functional Nanosystems and Nanostructures

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