Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy

Hyder, Safwan K; Ghosh, Anjik; Forcelli, Patrick A.

doi:10.1111/epi.17469

Cited by 4 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deep brain stimulation (DBS) and optogenetics are two cutting-edge technologies developed as potential treatments for epilepsy without resecting brain tissue. − DBS employs implanted electrodes to deliver electrical stimulation, − whereas optogenetics utilizes rigid optical fibers to activate neural circuits through light exposure selectively. , While DBS and optogenetics have shown promise as potential therapies for epilepsy, their application requires brain implants. Prolonged implantation may lead to chronic immune inflammation and permanent tissue damage within the brain .…”

mentioning

confidence: 99%

“…Presently, neuromodulation techniques (DBS and Optogenetics) in addressing epilepsy involve regulating atypical neural activity in the brain by stimulating specific neural pathways. − Nanomaterial-enabled optical neuromodulation represents a highly effective approach for modulating neural excitability in contemporary neuroscience research and applications and has emerged as a promising neuromodulation strategy in neurological disorder treatment, including epilepsy. − Employing photosensitive materials enables nongenetic neuromodulation by generating electrical and thermal stimuli − that neurons can perceive through precise light irradiation. Photosensitive materials can be precisely targeted to specific neural circuits via stereotactic injection, obviating the need for implants.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Black Phosphorus Flake-Enabled Wireless Neuromodulation for Epilepsy Treatment

Yang,

Ren,

Nie

et al. 2023

Nano Lett.

View full text Add to dashboard Cite

Epilepsy is a prevalent and severe neurological disorder and generally requires prolonged electrode implantation and tether brain stimulation in refractory cases. However, implants may cause potential chronic immune inflammation and permanent tissue damage due to material property mismatches with soft brain tissue. Here, we demonstrated a nanomaterial-enabled near-infrared (NIR) neuromodulation approach to provide nongenetic and nonimplantable therapeutic benefits in epilepsy mouse models. Our study showed that crystal-exfoliated photothermal black phosphorus (BP) flakes could enhance neural activity by altering the membrane capacitive currents in hippocampus neurons through NIR photothermal neuromodulation. Optical stimulation facilitated by BP flakes in hippocampal slices evoked action potentials with a high spatiotemporal resolution. Furthermore, BP flake-enabled NIR neuromodulation of hippocampus neural circuits can suppress epileptic signals in epilepsy model mice with minimal invasiveness and high biocompatibility. Consequently, nanomaterial-enabled NIR neuromodulation may open up opportunities for nonimplantable optical therapy of epilepsy in nontransgenic organisms.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Black Phosphorus Flake-Enabled Wireless Neuromodulation for Epilepsy Treatment

Yang,

Ren,

Nie

et al. 2023

Nano Lett.

View full text Add to dashboard Cite

show abstract

Decoding Epileptic Seizures: Exploring In Vitro Approaches to Unravel Pathophysiology and Propel Future Therapeutic Breakthroughs

Heydari,

Bozzi,

Pavesi

2024

Biomedical Materials & Devices

View full text Add to dashboard Cite

Epilepsy is a chronic neurological disorder associated with various symptoms, contingent upon the specific brain region involved. Unpredictable seizures characterize epilepsy, significantly influencing the quality of the patient’s life. Globally, epilepsy affects 1% of the population, with 30% of individuals developing drug resistant epilepsy despite anti-epileptic pharmacological treatment. While several anticonvulsant drugs alleviate epilepsy symptoms, there is currently no effective medication to cure this neurological disorder. Therefore, overcoming the challenges of predicting and controlling drug-resistant seizures requires further knowledge of the pathophysiology of epilepsy at the molecular and cellular levels. In this review, we delve into in vitro experiments that prove valuable in elucidating the mechanisms of drug-resistant epilepsy, as well as in the development and testing of novel therapeutic approaches prior to extensive animal-based trials. Specifically, our focus is on the utility of multi-electrode array (MEA) recording as an in vitro technique for evaluating aberrant electrical activity within neural networks. Real-time MEA recording from neuronal cultures facilitates monitoring of neurotoxicity, dose response, and the efficacy of newly-designed drugs. Additionally, when coupled with emerging techniques such as optogenetics, MEA enables the creation of closed-loop systems for seizure prediction and modulation. These integrated systems contribute to both prospective therapy and the study of intracellular pathways in drug-resistant seizures, shedding light on their impact on neuronal network activity.

show abstract