Optogenetic stimulation of the auditory pathway for research and future prosthetics

Moser, Tobias

doi:10.1016/j.conb.2015.01.004

Cited by 62 publications

(64 citation statements)

References 56 publications

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“…25 However, despite these results, many patients continue to report difficulty hearing in noisy environments and with music perception. 24, 26, 27 As reviewed in Richter et al (2013), while there are at most 22 electrodes, only 4-7 channels are truly independent versus the estimated 30-50 channels in normal hearing subjects. The main problem is thought to be the spread of current (spread of excitation) away from active electrodes.…”

Section: Optical Neural Stimulation and Optical Cochlear Implantsmentioning

confidence: 98%

“…24 Both strategies have advantages and limitations. Acoustic stimulation relies on the presence of mechanoacoustic stimulation of the cochlea, typically with amplified and filtered signals (e.g.…”

Section: Optical Neural Stimulation and Optical Cochlear Implantsmentioning

confidence: 99%

“…4, 24, 27, 28 The precision that light stimulation may offer could allow for the creation of more focal stimulation and thus more independent channels of information flow. 27 Light energy has been found to excite many different types of tissues including peripheral nerve, cortical cells, cardiomyocytes, and isolated neurons.…”

Section: Optical Neural Stimulation and Optical Cochlear Implantsmentioning

confidence: 99%

See 2 more Smart Citations

On the Horizon

Roche

Hansen

2015

Otolaryngologic Clinics of North America

112

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Section: Optical Neural Stimulation and Optical Cochlear Implantsmentioning

confidence: 98%

Section: Optical Neural Stimulation and Optical Cochlear Implantsmentioning

confidence: 99%

Section: Optical Neural Stimulation and Optical Cochlear Implantsmentioning

confidence: 99%

See 1 more Smart Citation

On the Horizon

Roche

Hansen

2015

Otolaryngologic Clinics of North America

112

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“…Relatively minor improvements included pre-curved electrode arrays to get stimulation sites closer to the cochlear modiolus, thus to the auditory neurons [22] and atraumatic surgical techniques to preserve and promote the health of residual auditory neurons [23]. Several innovative lines of research are also emerging to change this direction, such as injecting neurotrophin or stem cells to attract neurons to grow toward electrodes [24, 25], using needle or thin-film electrodes to penetrate the auditory nerve bundle [26, 27], or optogenetically stimulating the auditory nerve [28]. Unfortunately, these new strategies are still in their exploratory stages and are years, if not decades, away from human application.…”

Section: Solutionsmentioning

confidence: 99%

Challenges in Improving Cochlear Implant Performance and Accessibility

Zeng

2017

IEEE Trans. Biomed. Eng.

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Here I identify two gaps in cochlear implants that have been limiting their performance and acceptance. First, cochlear implant performance has remained largely unchanged, despite the number of publications tripling per decade in the last 30 years. Little has been done so far to address a fundamental limitation in the electrode-to-neuron interface, with the electrode size being a thousand times larger than the neuron diameter while the number of electrodes being a thousand times less. Both the small number and the large size of electrodes produce broad spatial activation and poor frequency resolution that limit current cochlear implant performance. Second, a similarly rapid growth in cochlear implant volume has not produced an expected decrease in unit price in the same period. The high cost contributes to low market penetration rate, which is about 20% in developed countries and less than 1% in developing countries. I will discuss changes needed in both research strategy and business practice to close the gap between prosthetic and normal hearing as well as that between haves and have-nots.

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“…To address this scalability issue, an alternative approach is to have light sources integrated onto the probe and capable of being inserted into the brain. Microscale light-emitting diodes (μLEDs) offer such a solution17181920. A multimodal implant has been developed with four connected μLEDs17.…”

Section: Introductionmentioning

confidence: 99%

Depth-specific optogenetic control in vivo with a scalable, high-density μLED neural probe

Scharf¹,

Tsunematsu

McAlinden

et al. 2016

Sci Rep

132

111

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Controlling neural circuits is a powerful approach to uncover a causal link between neural activity and behaviour. Optogenetics has been widely adopted by the neuroscience community as it offers cell-type-specific perturbation with millisecond precision. However, these studies require light delivery in complex patterns with cellular-scale resolution, while covering a large volume of tissue at depth in vivo. Here we describe a novel high-density silicon-based microscale light-emitting diode (μLED) array, consisting of up to ninety-six 25 μm-diameter μLEDs emitting at a wavelength of 450 nm with a peak irradiance of 400 mW/mm2. A width of 100 μm, tapering to a 1 μm point, and a 40 μm thickness help minimise tissue damage during insertion. Thermal properties permit a set of optogenetic operating regimes, with ~0.5 °C average temperature increase. We demonstrate depth-dependent activation of mouse neocortical neurons in vivo, offering an inexpensive novel tool for the precise manipulation of neural activity.

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Optogenetic stimulation of the auditory pathway for research and future prosthetics

Cited by 62 publications

References 56 publications

On the Horizon

On the Horizon

Challenges in Improving Cochlear Implant Performance and Accessibility

Depth-specific optogenetic control in vivo with a scalable, high-density μLED neural probe

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