Optoperforations of Retinal Blood Vessels in an Intact Porcine Eye by Using a Femtosecond Laser-assisted Microsurgery System

Sidhu, Mehra S.; Woo, Suk-Yi; Kim, Wan Kee; Lee, Heung Soon; Yahng, J. S.; Kim, Kyu-Jin; Jeoung, Sae Chae; Lee, Hyun Kyu

doi:10.3938/jkps.58.1605

Cited by 2 publications

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“…fs ultrashort pulsedlasers for enclosure of corneal neovascularization in the presence of ICG at 3.8 J/cm 2 was employed by Sawa et al in 2004 [53]. The MVL threshold values determined in the current study are in good agreement with previous reports [45,53,54], despite that no dye or photodynamic chemical agents were applied during the procedures.…”

Section: Corneal Vessel Ablationsupporting

confidence: 89%

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Ablation of Materials Using Femtosecond Lasers and Electron Beams

Sidhu¹,

Dhingra²

2022

Terahertz, Ultrafast Lasers and Their Medical and Industrial Applications

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The advancements in producing interactions of concentrated energy fluxes, such as femtosecond lasers and high-energy electron beams with the absorbing substances, have facilitated new discoveries and excitement in various scientific and technological areas. Since their invention, significant improvements in temporal, spatial, energetic, and spectroscopic characteristics have been realized. Due to the ultrashort pulse width and higher intensity (1012 W/cm2), it is possible to ablate the materials with negligible damage outside the focal volume, thereby allowing the treatment of biological samples, such as live cells, membranes, and removal of thin films, as well as bulk materials for many applications in diverse fields, including micro-optics, electronics, and even biology under extremely high precision. Since most biological systems are transparent toward the NIR spectral range, it follows the nonlinear multi-photon absorption interaction mechanism. In contrast, the electron beam follows linear absorption mechanism for material modifications even at lower energies. For realizing the fs-laser nano-processing in material applications, such as silicon microchips, or in biology like retinal cells, it is crucial to find a way to deliver these pulses precisely at the site of action and enhance the selectivity. The utilization of electron beams in material modification has also been exercised widely to attain nanoscale precision. In the next section, biological materials, such as cornea, retina, and silk, are discussed.

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Section: Corneal Vessel Ablationsupporting

confidence: 89%

“…The experimental setup for fs-laser ablation of a porcine retina and as well as its blood vessels has been discussed in Ref. [45]. The laser system consists of a [32].…”

Section: Experimental Techniquementioning

confidence: 99%

Ablation of Materials Using Femtosecond Lasers and Electron Beams

Sidhu¹,

Dhingra²

2022

Terahertz, Ultrafast Lasers and Their Medical and Industrial Applications

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Femtosecond laser-assisted selective reduction of neovascularization in rat cornea

et al. 2014

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Nonlinear multiphoton absorption induced by focusing near infrared (NIR) femtosecond (fs) laser pulses into a transparent cornea allows surgery on neovascular structures with minimal collateral damage. In this report, we introduce an fs laser-based microsurgery for selective treatment of rat corneal neovascularizations (in vivo). Contiguous tissue effects are achieved by scanning a focused laser pulse below the corneal surface with a fluence range of 2.2–8.6 J/cm2. The minimal visible laser lesion (MVL) threshold determined over the corneal neovascular structures was found to be 4.3 J/cm2. Histological and optical coherence tomography examinations of the anterior segment after laser irradiations show localized degeneration of neovascular structures without any unexpected change in adjacent tissues. Furthermore, an approximately 30 % reduction in corneal neovascularizations was observed after 5 days of fs laser exposure. The femtosecond laser is thus a promising tool for minimally invasive intrastromal surgery with the aid of a significantly smaller and more deterministic photodisruptive energy threshold for the interaction between the fs laser pulse and corneal neovascular structures.

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Optoperforations of Retinal Blood Vessels in an Intact Porcine Eye by Using a Femtosecond Laser-assisted Microsurgery System

Cited by 2 publications

References 0 publications

Ablation of Materials Using Femtosecond Lasers and Electron Beams

Ablation of Materials Using Femtosecond Lasers and Electron Beams

Femtosecond laser-assisted selective reduction of neovascularization in rat cornea

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