Optymalizacja ekstrakcji polifenoli z Mentha spicata różnymi rozpuszczalnikami

Najda, Agnieszka; Klimek, Kamila; Balant, Sebastian; Wrzesińska-Jędrusiak, Edyta; Piekarski, W.

doi:10.15199/62.2019.8.16

Cited by 3 publications

(2 citation statements)

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“…One of the limitations of using quercetin in patients undergoing IS is that its effectiveness varies substantially depending on the type of source plant, the dose and the chemical properties after processing [ 126 ]. In humans, quercetin has low bioavailability, and it is noteworthy that it poorly crosses the BBB [ 127 ].…”

Section: Natural Antioxidant Bioactive Molecules Against Myocardial I...mentioning

confidence: 99%

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Orellana-Urzúa,

Briones-Valdivieso,

Chichiarelli

et al. 2023

Antioxidants

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Stroke and acute myocardial infarction are leading causes of mortality worldwide. The latter accounts for approximately 9 million deaths annually. In turn, ischemic stroke is a significant contributor to adult physical disability globally. While reperfusion is crucial for tissue recovery, it can paradoxically exacerbate damage through oxidative stress (OS), inflammation, and cell death. Therefore, it is imperative to explore diverse approaches aimed at minimizing ischemia/reperfusion injury to enhance clinical outcomes. OS primarily arises from an excessive generation of reactive oxygen species (ROS) and/or decreased endogenous antioxidant potential. Natural antioxidant compounds can counteract the injury mechanisms linked to ROS. While promising preclinical results, based on monotherapies, account for protective effects against tissue injury by ROS, translating these models into human applications has yielded controversial evidence. However, since the wide spectrum of antioxidants having diverse chemical characteristics offers varied biological actions on cell signaling pathways, multitherapy has emerged as a valuable therapeutic resource. Moreover, the combination of antioxidants in multitherapy holds significant potential for synergistic effects. This study was designed with the aim of providing an updated overview of natural antioxidants suitable for preventing myocardial and cerebral ischemia/reperfusion injuries.

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Section: Natural Antioxidant Bioactive Molecules Against Myocardial I...mentioning

confidence: 99%

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Orellana-Urzúa,

Briones-Valdivieso,

Chichiarelli

et al. 2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…The plant source, dosage, and chemical qualities after preparation are the major factors that affect Que's efficacy [53]. Quercetin has been given the GRAS (generally regarded as safe) designation by the US Food and Drug Administration (USFDA), up to a daily dose of 500 mg [54].…”

Section: Overview Of Quercetinmentioning

confidence: 99%

Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments

Zamanian

Soltani

Khodarahmi

et al. 2023

Fundamemntal Clinical Pharma

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Background: Neurological disorders (NLDs) are widely acknowledged as a significant public health concern worldwide. Stroke, Alzheimer's disease (AD), and traumatic brain injury (TBI) are three of these disorders that have sparked major study attention. Neurological dysfunction, protein buildup, oxidation and neuronal injury, and aberrant mitochondria are all prevalent neuropathological hallmarks of these disorders. The signaling cascade of nuclear factor erythroid 2 related factor 2 (Nrf2) shares all of them as a common target. Several studies have found that overexpression of Nrf2 is a promising treatment method in NLDs. Effective treatment of these disorders continues to be a universal concern regardless of various medicines. In order to treat a variety of neurological problems, organic remedies may provide an alternative treatment. It has been demonstrated that polyphenols like quercetin (Que) offer considerable capabilities for treating NLDs. One of Que's greatest key targets, Nrf2, has the capacity to control the production of a number of cytoprotective enzymes that exhibit neuroprotective, detoxifying, and antioxidative effects. Additionally, Que enhanced the expression of Nrf2 and inhibited alterations in the shape and death of neurons in the hippocampus. Objective: In this review, we have focused on Que's medicinal prospects as a neuroprotective drug. Methods: PubMed, Scopus, Science Direct, and Google Scholar were used to search articles for this study. Results: The findings of this research demonstrate that (1) Que protected the blood‐brain barrier via stimulating Nrf2 in animal stroke, which alleviated ischemic reperfusion and motor dysfunction. (2) By triggering the Nrf2 pathway, Que reduced the neuroinflammation and oxidative damage brought on by TBI in the cortex. (3) In an experimental model of AD, Que enhanced cognitive function by decreasing A1‐4, antioxidant activity, and Nrf2 levels in the brain. Conclusion: We discuss recent research on Que‐mediated Nrf2 expression in the management of several NLDs in this paper.

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Do AMF and Irrigation Regimes Affect Sweet Pepper Fruit Quality under Open Field Conditions?

2021

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The aim of this study was to determine the effect of a mycorrhizal inoculation (AMF) and irrigation regime on certain yield morphological parameters and the biological value of fruits of open field-grown sweet pepper under temperate climate conditions. A study on the Polish hybrid cultivar ‘Roberta F1’ was conducted over the period 2016–2018 in a private certified organic farm. Sweet pepper was harvested at physiological maturity from the second 10 days of August to the first 10 days of October. AMF and irrigation were shown to significantly modify the selected morphological parameters of the peppers. Fruits with the highest weight, length, and width were harvested from AMF-inoculated plants, both irrigated and non-irrigated ones. The chemical composition and antioxidant activity (AA) of pepper fruit extracts were significantly affected by AMF and irrigation. AMF application contributed to a decrease in the percentage of dry matter, vitamin C, reducing sugars, extract, carotenoids, and AA. Irrigation, on the other hand, had a beneficial effect on enhancing the biological value of pepper fruits (except for vitamin C), also increasing their AA. The highest levels of carotenoids (4.64 mg 100 g−1 of fresh matter (FM) were found in the fruits of irrigated plants without AMF, whereas the highest levels of vitamin C (134.10 mg 100 g−1 FM) were accumulated by the fruits of plants grown without AMF and without irrigation.

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Optymalizacja ekstrakcji polifenoli z Mentha spicata różnymi rozpuszczalnikami

Cited by 3 publications

References 1 publication

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments

Do AMF and Irrigation Regimes Affect Sweet Pepper Fruit Quality under Open Field Conditions?

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