Opuntia ficus-indica attenuates neuronal injury in in vitro and in vivo models of cerebral ischemia

Kim, Jung-Hoon; Park, Shin-Mi; Ha, Hyun-Joo; Moon, Changjong; Shin, Taekyun; Kim, Jung-Mi; Lee, Nam-Ho; Kim, Hyoung‐Chun; Jang, Kyung-Jin; Wie, Myung‐Bok

doi:10.1016/j.jep.2005.09.017

Cited by 59 publications

(45 citation statements)

References 18 publications

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“…Potential betalain absorption varies from 40% to 78% (Tesoriere, Fazzari, Angileri, Gentile, & Livrea, 2008), but once absorbed, the betalains play a protective role in the human body (Lee, Hyun, Li, & Moon, 2001;Sreekanth et al, 2007;Zou et al, 2005). Betalains are reported to boost the immune system (Siriwardhana, Shahidi, & Jeon, 2006), protect the liver (Galati et al, 2005), and shield the brain from harmful elements (Kim et al, 2006).…”

Section: Betalain Quantificationmentioning

confidence: 99%

Effect of storage time on physicochemical and textural properties of sausages covered with oxidized banana starch film with and without betalains

Zamudio‐Flores

Ochoa-Reyes

Ornelas-Paz

et al. 2015

CyTA - Journal of Food

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-Félix (2015) Effect of storage time on physicochemical and textural properties of sausages covered with oxidized banana starch film with and without betalains, CyTA -Journal of Food, 13:3, 456-463, DOI: 10.1080/19476337.2014 To link to this article: https://doi.org/10. 1080/19476337.2014 In this study, two types of oxidized banana starch films (betalains and no betalains) were prepared and used as covering for sausages, then were refrigerated for 20 days at 4°C and 5% relative humidity (RH). The sausages covered were analyzed (covered with films without betalains = F1 and covered with films with betalains = F2) and they were compared with a control (without covering). The sausages were evaluated every 5 days by physicochemical analysis of color, size, weight loss, pH and quantification of betalains in the films. Textural analysis was performed on the sausages. The results indicated that films did not significantly alter the color or moisture loss during storage (P > 0.05), while the F2 films maintained the amount of thiobarbituric acid reactive substances in the sausages during storage (P < 0.05). Sausages covered with both types of film maintained their texture characteristics for longer compared to the control.Keywords: color evaluation; betalains content; texture profile analysis; sausages En el presente estudio se elaboraron dos tipos de películas de almidón oxidado de plátano (con y sin betalaínas) y se utilizaron como cubiertas en salchichas, las cuales se almacenaron por 20 días en condiciones de refrigeración (4°C y 5% HR). Se analizaron tres lotes de salchichas (sin cubierta = control; cubiertas con películas sin betalaínas = F1; cubiertas con películas con betalaínas = F2). Las salchichas se evaluaron cada cinco días mediante análisis fisicoquímicos de color, tamaño, pérdida de peso, pH y cuantificación del nivel de betalaínas en las películas. Se realizó un análisis de textura de las salchichas. Los resultados indicaron que las películas no alteraron significativamente el color o la pérdida de humedad durante el almacenamiento (P > 0,05), mientras que las películas F2 mantuvieron la cantidad de substancias reactivas de ácido tiobarbitúrico (TBARS) en las salchichas durante el almacenamiento (P < 0,05). Las salchichas cubiertas con ambos tipo de películas conservaron sus atributos de textura por mayor tiempo en comparación con las salchichas control. Palabras

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Section: Betalain Quantificationmentioning

confidence: 99%

Effect of storage time on physicochemical and textural properties of sausages covered with oxidized banana starch film with and without betalains

Zamudio‐Flores

Ochoa-Reyes

Ornelas-Paz

et al. 2015

CyTA - Journal of Food

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“…They observed that pre-and co-treated mouse cortical cells with the fruit methanol extract at the concentrations of 300 μg/ml and above protected from the toxicity induced by NMDA (25 μM) for 20-24 h (Fig. 1 in Kim et al, 2006). Although it may be difficult to directly compare their data to ours because of the different experimental systems and conditions employed, our butanol fraction from the stems seems to exert more potent inhibition of the NMDA toxicity (Fig.…”

Section: Discussionmentioning

confidence: 53%

“…2, the NMDAinduced toxicity was inhibited more potently and dramatically, with the IC 50 of 50.6 μg/ml. According to the recent paper reported by Kim et al (2006), the methanol extract of the fruits was also capable of inhibiting NMDA-, KA-, or oxygen-glucose deprivation-induced neurotoxicity. They observed that pre-and co-treated mouse cortical cells with the fruit methanol extract at the concentrations of 300 μg/ml and above protected from the toxicity induced by NMDA (25 μM) for 20-24 h (Fig.…”

Section: Discussionmentioning

confidence: 92%

Neuroprotective and Antioxidant Effects of the Butanol Fraction Prepared from Opuntia ficus-indica var. saboten

Cho¹,

Han²,

Lee³

et al. 2007

Biomolecules and Therapeutics

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− The fruits and stems of Opuntia ficus-indica var. saboten have been reported to exhibit a variety of pharmacological actions, including antioxidant, analgesic, anti-inflammatory, and anti-ulcer effects. In the present study, we evaluated effects of the butanol fraction (SK OFB901) prepared from the 50% ethanol extract of the stems on various types of neuronal injuries induced by oxidative stress, excitotoxins, and amyloid β (A β ) in primary cultured rat cortical cells. Its antioxidant and radical scavenging activities were also evaluated by cell-free bioassays. We found that SK OFB901 strongly inhibited the oxidative neuronal damage induced by H 2 O 2 or xanthine/xanthine oxidase. In addition, it exhibited marked inhibition of the excitotoxic neuronal damage induced by glutamate, N-methyl-D-aspartic acid, or kainate. Furthermore, the A β(25-35) -induced neurotoxicity was also significantly attenuated by SK OFB901. It was found to inhibit lipid peroxidation initiated by Fe 2+ and L-ascorbic acid in rat brain homogenates and scavenge 1,1-diphenyl-2-picrylhydrazyl free radicals. These results indicate that the butanol fraction prepared from the stems of Opuntia ficus-indica var. saboten exerts potent antioxidant and neuroprotective effects through multiple mechanisms, implying its potential applications for the prevention or management of neurodegenerative disorders associated with oxidative stress, excitotoxicity, and A β .

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“…Moreover recently reported that quercetin, a component of Opuntia ficus-indica, had a neuroprotective action against Nmethyl-d-aspartate (NMDA), kainate (KA), and oxygen-glucose deprivation (OGD)-induced neurotoxicity in cultured rat cortical cell and in vivo global ischemia induced cultured gerbils cortical cells, (Ha et al, 2003). Methanol extract of Opuntia ficus-indica (MEOF) has a neuroprotective action against (NMDA), (KA), and (OGD)-induced neuronal injury in cultured mouse cortical cells and also reported the neuroprotective effect of MEOF in the hippocampal against neuronal damage evoked by global ischemia in gerbils (Kim et al, 2006).…”

Section: Neuroprotectivementioning

confidence: 98%

“…Through antioxidant actions and also used for treating diabetes, burns, bronchial, asthma and indigestion in many countries over the world (Kim et al, 2006). One of the most frequently utilized fruit and vegetable technologies is juice production.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological actions of Opuntia ficus indica: A Review

Kaur¹

2012

J. App. Pharm. Sci.

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Cactus (Opuntia ficus-indica) belongs to the family Cactaceae. Family Cactaceae is reported to contain about 130 genera and nearly 1500 species. This plant is native of Mexico and it is widely distributed in Mexico and in all American hemispheres as well as in Africa and in the Mediterranean basin. It has been used in traditional folk medicine because of its role in treating a number of diseases and conditions, including anti-inflammatory effects hypoglycemic effects inhibition of stomach ulceration, neuroprotective effects Through antioxidant actions and also used for treating diabetes, burns, bronchial, asthma and indigestion in many countries over the world. It is also used in Pharma industry as a pharmaceutical agent. The fruit, as well as cactus stem are used to prepare value-added products, such as jam, squash, wine, pickle, body lotions, shampoo, creams, etc. It also has several medicinal and industrial uses. Its seeds can be used as flavouring agents. Due to the remarkable biological activity of Opuntia and its constituents, it will be appropriate to develop them as a medicine.

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Opuntia ficus-indica attenuates neuronal injury in in vitro and in vivo models of cerebral ischemia

Cited by 59 publications

References 18 publications

Effect of storage time on physicochemical and textural properties of sausages covered with oxidized banana starch film with and without betalains

Effect of storage time on physicochemical and textural properties of sausages covered with oxidized banana starch film with and without betalains

Neuroprotective and Antioxidant Effects of the Butanol Fraction Prepared from Opuntia ficus-indica var. saboten

Pharmacological actions of Opuntia ficus indica: A Review

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