Opuntia monacantha: Validation of the anti-inflammatory and anti-arthritic activity of its polyphenolic rich extract in silico and in vivo via assessment of pro- and anti-inflammatory cytokines

Potential Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports

“…Moreover, the addition of 20% dried plums into the normal diet of transgenic mice with induced-RA showed notable protective effects in protecting articular cartilage, reducing synovitis, IL-1β, MCP1, MIP1α, MMP1, and MPP3, and RANKL expression and repressing TNF-induced formation of osteoclasts and mRNA levels of cathepsin K and MMP9 by inhibiting nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression, and NF-κB activation [360]. On the other hand, 750 mg/kg Opuntia monacantha showed effectiveness in reducing paw edema, the arthritic score, the rheumatoid factor, inflammation, COX-2, IL-6, TNF-α, IL-1, NF-κB, bone erosion, and pannus formation, restoring hemoglobin, white blood count, and platelet parameters, increasing catalase and superoxide dismutase levels, and enhancing IL-4 and IL-10, namely, by its potential to inhibit glutaminase 1 activity in a RA rat model [361]. In addition, 800 mg/kg Solanum nigrum also showed effectiveness in reducing paw edem, and restoring body weight, hematologic parameters, and radiographic and histopathologic alterations towards normal in different RA rat models [362].…”

“…Additionally, 25, 50, 100, 250, and 500 µM syringaldehyde, a small polyphenolic compound extracted from Capparis spinosa L., showed potential to diminish CD86, CD40, MHC II, and IL-23 expression and enhance IL-10 expression and antigen phagocytosis on human acute lymphoblastic leukemia T lymphocytes by inhibiting the MAPK/NF-κB signaling pathways [289]. Opuntia monacantha Rats with induced RA 750 mg/kg ↓ Paw edema, the arthritic score, the rheumatoid factor, inflammation, COX-2, IL-6, TNF-α, IL-1, NF-κB, bone erosion, and pannus formation Restore hemoglobin, white blood count, and platelet parameters ↑ Catalase and superoxide dismutase, IL-4 and IL-10 levels Inhibition of glutaminase 1 activity [361] Solanum nigrum Rats with induced RA 800 mg/kg ↓ Paw edema Restore body weight, hematologic parameters, and radiographic and histopathologic alterations [362] Quercetin and quercetin-loaded chitosan Rats with induced RA 15 mg/kg quercetin and 10 and 20 mg/kg quercetin-loaded chitosan ↓ TNF-α and IL-6…”

The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports

“…Moreover, the addition of 20% dried plums in the normal diet of transgenic mice with induced-RA showed notable protective effects in protecting articular cartilage, reducing synovitis, IL-1β, MCP1, MIP1α, MMP1 and MPP3, and RANKL expression and repressing TNF-induced formation of osteoclasts and mRNA levels of cathepsin K and MMP9 by inhibiting nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression and NF-κB activation [316]. On the other hand, 750 mg/kg Opuntia monacantha showed effectiveness in reducing paw edema, arthritic score, rheumatoid factor, inflammation, COX-2, IL-6, TNF-α, IL-1, NF-kB, bone erosion and pannus formation, restore hemoglobin, white blood count and platelets parameteres and increase catalase and superoxide dismutase levels, and enhance IL-4 and IL-10, namely by its potential to inhibit glutaminase 1 activity in a RA rat model [317]. In addition, 800 mg/kg Solanum nigrum also showed effectiveness in reducing paw edema, and restoring body weight, hematologic parameters, radiographic and histopathologic alterations towards normal in different RA rat models [318].…”

Investigating potential mechanisms of vitamin D against thyroid cancer via network pharmacology and experimental validation

“…Molecular docking and the calculation of free binding energy were carried out with AutoDock Vina 4.2. Finally, interactions, binding modes, and analyses of the receptor-ligand complexes were visualized and examined using Discovery Studio 4.5 (Abid et al, 2024).…”