2019
DOI: 10.1101/757880
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

OR1D2 receptor mediates bourgeonal-induced human CatSper activation in a G-protein dependent manner

Abstract: 33During fertilization, sperm are guided towards eggs by physiological chemokines, a 34 process named sperm chemotaxis. Human sperm chemotaxis is speculated to be 35 mediated by olfactory receptor OR1D2 in a pathway requiring calcium influx. 36 Bourgeonal, an artificial ligand of OR1D2, can activate CatSper, the primary calcium 37 channel in human sperm. However, whether bourgeonal-induced CatSper activation 38 requires OR1D2 and how CatSper is activated remain unclear. Herein, we show that 39 65 Surprising… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
2

Relationship

1
1

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 65 publications
0
1
0
Order By: Relevance
“…Sperm chemotaxis guides sperm toward the oocyte and is closely related to sperm capacitation, hyperactivation, the acrosome reaction, and male fertility. In humans, bourgeonal is a typical odorant and chemoattractant that is proposed to activate olfactory receptors (OR1D2) and to open CatSper to increase [Ca 2+ ] i via a G-protein-coupled receptor/olfactory G-protein/cAMP/PKA pathway [ 9 , 56 , 57 ]. Moreover, men with idiopathic infertility and low sensitivity to bourgeonal have decreased OR1D2 protein expression and bourgeonal-activated CatSper current in their sperm [ 58 ].…”
Section: Catsper and Physiological Chemicalsmentioning
confidence: 99%
“…Sperm chemotaxis guides sperm toward the oocyte and is closely related to sperm capacitation, hyperactivation, the acrosome reaction, and male fertility. In humans, bourgeonal is a typical odorant and chemoattractant that is proposed to activate olfactory receptors (OR1D2) and to open CatSper to increase [Ca 2+ ] i via a G-protein-coupled receptor/olfactory G-protein/cAMP/PKA pathway [ 9 , 56 , 57 ]. Moreover, men with idiopathic infertility and low sensitivity to bourgeonal have decreased OR1D2 protein expression and bourgeonal-activated CatSper current in their sperm [ 58 ].…”
Section: Catsper and Physiological Chemicalsmentioning
confidence: 99%