2019
DOI: 10.2174/1570163815666180629164332
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Oral Acute and Repeated-Doses Toxicity Study of Valepotriates from Valeriana glechomifolia (Meyer) in Mice

Abstract: Species of Valeriana show sedative, hypnotic, anxiolytic, antidepressant and anti-inflammatory properties, which are associated with valepotriates. However, data about toxicity and safety of these compounds are still limited. The aim of this study was to investigate the toxicity of a valepotriate-enriched fraction (VAL) from Valeriana glechomifolia Meyer based on the Organization for Economic Cooperation and Development (OECD) guidelines 423 and 407. In the acute study, CF1 mice were treated with a single dose… Show more

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Cited by 3 publications
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“…According to Organisation for Economic Co-operation and Development (OECD) Guideline 425, each animal received varying doses of the ethanolic extract of S. indicum (50–2000 mg/kg), and their behavior was observed persistently for 1 h, then at semi-intervals for 4 h for any gross change in behavior, and now for another 72 h for any death, followed by 14 days for any mortality. [ 11 ] Changes in skin, fur, mucus membrane (nasal), eyes, and autonomic salivation, lacrimation, sweat, dilation of blood vessels, urine incontinence, and feces), as well as central nervous system (tiredness, gait, tremors, and convulsion) modifications are evaluated once daily in the cage. S. indicum leaf extract has been demonstrated to be safe up to a level of 2,000 mg/kg of body weight.…”
Section: Methodsmentioning
confidence: 99%
“…According to Organisation for Economic Co-operation and Development (OECD) Guideline 425, each animal received varying doses of the ethanolic extract of S. indicum (50–2000 mg/kg), and their behavior was observed persistently for 1 h, then at semi-intervals for 4 h for any gross change in behavior, and now for another 72 h for any death, followed by 14 days for any mortality. [ 11 ] Changes in skin, fur, mucus membrane (nasal), eyes, and autonomic salivation, lacrimation, sweat, dilation of blood vessels, urine incontinence, and feces), as well as central nervous system (tiredness, gait, tremors, and convulsion) modifications are evaluated once daily in the cage. S. indicum leaf extract has been demonstrated to be safe up to a level of 2,000 mg/kg of body weight.…”
Section: Methodsmentioning
confidence: 99%