Oral adenosquamous carcinoma: Report of a rare entity with a special insight on its histochemistry

Sravya, Taneeru; Guttikonda, Venkateswara Rao; Kumar, Manchikatla Praveen; Sudheerkanth, K

doi:10.4103/0973-029x.190969

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…The histopathological characteristics of this tumor and now well described. Unlike some previous report where the diagnosis was made only with the aid of a substantial immunohistochemical panel, [5,6] few antibodies were used for diagnosis in this case. The selective positivities CK5/6 and CK7 and the characteristic morphological features (superficial epithelial component, deep glandular) allowed for an early diagnosis.…”

Section: Discussionmentioning

confidence: 95%

Adenosquamous carcinoma, a rare and unknown tumor

Benat

Cros

Sarini³

et al. 2018

J Oral Med Oral Surg

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Introduction: Adenosquamous carcinoma (ASC) of the head and neck is a rare malignant tumor, with one hundred cases diagnosed so far in the literature. Observation: A 66 years old female patient had a ASC of the right posterior floor of the mouth with a classification T1N0M0. Treatment consisted of surgical management and active surveillance. Discussion: Through this case report, we present this type of tumor and we discuss the main differential diagnosis from a clinical and histological point of view. Conclusion: This entity was described for the first time in 1968 by Gerughty. The CAS is defined by the World Health Organization as “a tumor of the upper respiratory tract, with two distinct squamous and glandular components.” The CAS is considered as an aggressive tumor with a redoubtable prognosis should not be ignored.

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Section: Discussionmentioning

confidence: 95%

Adenosquamous carcinoma, a rare and unknown tumor

Benat

Cros

Sarini³

et al. 2018

J Oral Med Oral Surg

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“…ASC is a rare, aggressive and highly invasive variant of SCC (15). Histologically, it is characterized by the simultaneous and distinct presence of two components: glandular and squamous (2).…”

Section: Discussionmentioning

confidence: 99%

“…Conventional SCC with ductal involvement occurs when neoplastic cells replace normal ductal cells. The abrupt transition from normal ductal epithelium to carcinoma is an important morphological feature for differentiation (15). The basaloid SCC is composed of basaloid and squamous components and is characterized by solid, large, rounded clumps of basaloid cells with comedo necrosis, a feature not observed in the ASC (12).…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous carcinoma in the palate of a dog: case report

Gomes¹,

Nóbrega²,

Azzem³

et al. 2022

BJVP

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Adenosquamous carcinoma is characterized by the simultaneous presence of squamous and glandular components. This article reports a case of adenosquamous carcinoma in the oral mucosa in a dog. Microscopically, the tumour revealed an infiltrative epithelial proliferation with a tubular pattern and areas of squamous differentiation. In the lumina of the tubules, there were eosinophilic material (mucin). The alcian blue staining showed positive intraluminal material and the cytoplasm of neoplastic cells were immunoreactive for cytokeratin, supporting the diagnosis of adenosquamous carcinoma. The cells exhibited reduced or negative immunoreactivity for E-cadherin, which could be associated with more aggressive tumour behaviour and worse prognosis.

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“…FaDu cells were established from a hypopharyngeal SCC. Cal27, derived from the tongue, was described earlier as adenosquamous carcinoma (17), a rather aggressive subtype of oral SCC (18). Detroit562 cells originating from a metastatic pharyngeal carcinoma were purchased from CLS (CLS Cell Lines Service GmbH).…”

Section: Hnscc Cell Lines Human Hnscc Cell Lines Fadu and Cal27mentioning

confidence: 99%

Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy

et al. 2022

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Increased submaxillary gland androgen-regulated protein 3A (SMR3A) expression was previously shown to serve as an independent risk factor for oropharyngeal squamous cell carcinoma (OPSCC) and as a surrogate biomarker for active estrogen receptor 2 signaling in radioresistant tumor cells. In the present study, it was aimed to unravel the expression and clinical significance of another member of the opiorphin family, opiorphin prepropeptide (OPRPN), in the radiotherapy for head and neck squamous cell carcinoma (HNSCC). Expression of SMR3A and OPRPN were analyzed for the prior and post fractionated irradiation (4x2 Gy) by double immunofluorescence staining in established HNSCC cell lines as well as by immunohistochemical (IHC) staining in ex vivo tumor tissues. Next, in a retrospective experimental cohort study, primary tumor samples from OPSCC patients (n=96), who received definitive surgery and adjuvant radiotherapy were reviewed, and expression levels of OPRPN protein were detected by IHC. Immunoreactivity scores (IRS) were associated with pathological and clinical risk factors by Chi-square analysis. Survival analysis was performed by using the Kaplan-Meier plot, log-rank test and Cox regression analysis. The expression levels of OPRPN and SMR3A protein were both induced by fractionated irradiation in vitro and ex vivo. In primary tumor samples, IRS of OPRPN was significantly higher than scores of SMR3A expression and positively correlated with expression patterns of SMR3A. SMR3A was confirmed to serve as an unfavorable factor, while OPRPN protein had no significant association with the clinical outcome of patients with OPSCC. A combinational analysis revealed that the subgroup with SMR3A high OPRPN low staining pattern had the worst clinical outcome among the various subgroups. Multivariate Cox regression analyses indicated that high expression of SMR3A serves as an independent unfavorable biomarker, while increased expression of OPRPN appears to exert protective function. In summary, the present study indicated that SMR3A and OPRPN serve as potential prognostic markers for HNSCC after radiotherapy.

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Oral adenosquamous carcinoma: Report of a rare entity with a special insight on its histochemistry

Cited by 11 publications

References 14 publications

Adenosquamous carcinoma, a rare and unknown tumor

Adenosquamous carcinoma, a rare and unknown tumor

Adenosquamous carcinoma in the palate of a dog: case report

Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy

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