Oral administration of a soluble 1–3, 1–6 β-glucan during prophylactic survivin peptide vaccination diminishes growth of a B cell lymphoma in mice

Harnack, Ulf; Eckert, K; Fichtner, Iduna; Pecher, Gabriele

doi:10.1016/j.intimp.2009.07.013

Cited by 17 publications

(12 citation statements)

References 49 publications

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“…Recent studies with 1,3/1,6-β- d -glucan compounds have shown promising results to indicate that they may be able to combat various microbial infections [5,22–25], yet nearly all of these studies have been performed in animal models. Here, we studied the effects of both soluble and particulate forms of yeast-derived bglucans, PGG and WGP, on mycobacterial infection of human macrophages.…”

Section: Discussionmentioning

confidence: 99%

β-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages

Betz

Azad

Morris

et al. 2011

Microbial Pathogenesis

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The yeast polysaccharide, β-glucan, has been shown to promote both anti-microbial and anti-tumor activities through its interaction with macrophages. Here we analyzed the effects of an insoluble whole glucan particle (WGP), a 1,3/1,6-β-glucan from Saccharomyces cerevisiae, and a soluble poly-1-6-β-d-glucopyranosyl-1-3-β-d-glucopyranose (PGG), a hydrolytic product of WGP, on the anti-microbial response of human macrophages against mycobacterial infection. Treatment of macrophages with WGP and PGG significantly decreased cell association and intracellular growth of Mycobacterium bovis BCG, but not Mycobacterium tuberculosis (M.tb) when compared to untreated controls. We characterized the influence of β-glucans on the generation of macrophage oxidative products and pro-inflammatory cytokines, two important anti-microbial defense mechanisms. WGP but not PGG treatment enhanced the oxidative response of macrophages as determined by the 2′,7′-dichlorofluorescin (DCF) assay. WGP treatment also induced macrophages to produce pro-inflammatory cytokines. The β-glucan receptor, Dectin-1, was found to be involved in the WGP-induced macrophage oxidative burst and intracellular growth inhibition of M. bovis BCG. This report indicates that although some forms of β-glucan are able to stimulate the respiratory burst and cytokine production in human macrophages, and exhibit antimicrobial properties against M. bovis BCG, the β-glucans tested here did not inhibit growth of M.tb within human macrophages.

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Section: Discussionmentioning

confidence: 99%

β-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages

Betz

Azad

Morris

et al. 2011

Microbial Pathogenesis

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“…One of the indicators studied most frequently after treatment is the quantity of T lymphocytes, especially CD8 + T cells, infiltrating the tumor [87]. In an A20 B-cell lymphoma model implanted subcutaneously, treatment by survivin or an idiotype-binding peptide, is correlated with increased CD8 + T-cell infiltration [63, 88]. Some therapies are clearly designed to boost immune response.…”

Section: Models To Analyze the Efficacy Of New Therapiesmentioning

confidence: 99%

Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies

Donnou

Galand

Touitou

et al. 2012

Advances in Hematology

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Human B-cell lymphomas, the fourth most common hematologic malignancy, are currently the subject of extensive research. The limited accessibility of biopsies, the heterogeneity among patients, and the subtypes of lymphomas have necessitated the development of animal models to decipher immune escape mechanisms and design new therapies. Here, we summarize the cell lines and murine models used to study lymphomagenesis, the lymphoma microenvironment, and the efficacy of new therapies. These data allow us to understand the role of the immune system in the fight against tumors. Exploring the advantages and limitations of immunocompetent versus immunodeficient models improves our understanding of the molecular and cellular mechanisms of tumor genesis and development as well as the fundamental processes governing the interaction of tumors and their host tissues. We posit that these basic preclinical investigations will open up new and promising approaches to designing better therapies.

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“…9,15 Moreover, b-glucans have recently been reported to enhance Ag-specific T cell and B cell responses. [16][17][18] In our previous studies, it has been confirmed that WGPs accelerate the differentiation of MDSCs as well as inhibiting the suppressive function of MDSCs via Dectin-1/Syk pathway. 19 However, the molecular mechanism of regulation on MDSCs by WGP is still unknown.…”

Section: 13mentioning

confidence: 73%

“…30 Furthermore, it has been recently reported b-glucans enhance Ag-specific T cells and B cells responses by promoting the maturation and antigen presentation of DCs. 12,[16][17][18]31 Thus, b-glucans play a key role in the innate and adaptive immune responses. We have indicated that WGP can regulate the differentiation and immunosuppression of MDSCs as this NF-kB dependent regulation is through Dectin-1/Syk pathway.…”

Section: Administration Of Sinfia Into Tumor Tissue Delays Tumor Progmentioning

confidence: 99%

Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression

Tian

Tang

et al. 2015

OncoImmunology

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Oral administration of a soluble 1–3, 1–6 β-glucan during prophylactic survivin peptide vaccination diminishes growth of a B cell lymphoma in mice

Cited by 17 publications

References 49 publications

β-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages

β-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages

Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies

Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression

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