Oral administration of caffeic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine

Arivarasu, N. A.; Priyamvada, Shubha; Mahmood, Riaz

doi:10.1016/j.etp.2011.05.004

Cited by 34 publications

(29 citation statements)

References 38 publications

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“…Also, the antioxidants in intestinal tissue is drastically decreased in the cisplatin administered animals due to the decreased activity of antioxidant enzyme pool, viz., Catalase (Cat), glutathione peroxidase (GPx), glutathione reductase (GR), and Glucose-6-phosphate dehydrogenase (G6PD) and a phase-II detoxifying enzyme, namely, Glutathione-S-Transferase (GST), and quinone reductase (QR). In addition, the levels of Superoxide dismutase (SOD) showed a steep increase [51,62]. Myricetin treatment restored the normal level of these antioxidant enzymes and improved the level of phase-II detoxifying enzymes in accordance with previous published reports [2,68] (Tables 1 and 2).…”

Section: Discussionsupporting

confidence: 89%

“…The long-chain free fatty acids are speculated to be responsible for functional and structural abnormalities in subcellular and plasma membranes [61]. One of the key markers of oxidative stress, malondialdehyde (MDA), is an intermediate product for lipid peroxidation, and it has been found to increase after cisplatin treatment [6,11,60,62]. Our results showed a similar pattern of increased lipid membrane peroxidation as reported previously, and treatment with myricetin reduced the abnormal levels of MDA [63] (Figure 2).…”

Section: Discussionsupporting

confidence: 86%

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Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Rehman

Rather

2019

Plants

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Cisplatin [cis-diamminedichloroplatinum II] is an extensively prescribed drug in cancer chemotherapy; it is also useful for the treatment of diverse types of malignancies. Conversely, cisplatin is associated with a range of side effects such as nephrotoxicity, hepatotoxicity, gastrointestinal toxicity, and so on. Myricetin (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4chromenone) is a very common natural flavonoid found in fruits, tea, and plants. It has been found to have high-value pharmacological properties and strong health benefits. To examine the role of myricetin in colon toxicity induced by cisplatin, we conducted a concurrent prophylactic study in experimental animals that were treated orally with myricetin for 14 days at two doses—25 and 50 mg/kg of body weight. On the 14th day, a single intraperitoneal injection of cisplatin (7.5 mg/kg body weight) was administered in all groups except control. The effects of myricetin in cisplatin-induced toxicity in the colon were assessed in terms of antioxidant status, phase-II detoxification enzymes, the level of inflammatory markers, and goblet cell disintegration. Myricetin was found to restore the level of all the antioxidant enzymes analyzed in the study. In addition, the compound ameliorated cisplatin-induced lipid peroxidation, increase in xanthine oxidase activity, and phase-II detoxifying enzyme activity. Myricetin also attenuated deteriorative effects induced by cisplatin by regulating the level of molecular markers of inflammation (NF-κB, Nrf-2, IL-6, and TNF-α), restoring Nrf-2 levels, and controlling goblet cell disintegration. The current study reinforces the conclusion that myricetin exerts protection in colon toxicity via up-regulation of inflammatory markers, improving anti-oxidant status, and protecting tissue damage.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 86%

Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Rehman

Rather

2019

Plants

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“…And it is consistent with earlier studies where administration of cisplatin caused lipid peroxidation and inflammation (Arivarasu et al, 2013;Ronald et al, 2010;Sreedevi et al, 2010). This increased lipid peroxidation may be resulting from depletion in the exogenous antioxidant system such as SOD, GST, and CAT (Table 6); it is consistent with an earlier study where Table 5.…”

Section: Discussionsupporting

confidence: 81%

“…Group I, normal rats fed basal diet; Group II, control rats administered cisplatin and fed basal diet; Group III, cisplatin-administered rats fed diet supplemented with 0.5% sorghum straw dye; Group IV, cisplatin-administered rats fed diet supplemented with 1% sorghum straw dye. depletion in SOD, CAT and GST in rat kidney resulted in increased MDA concentration (Arivarasu et al, 2013). This compromised kidney endogenous antioxidant status is an indication that cisplatin-induced nephrotoxicity is a function of oxidative stress (Ahmed, 2010;Yao et al, 2007).…”

Section: Groupmentioning

confidence: 99%

Dietary inclusion of sorghum (Sorghum bicolour) straw dye protects against cisplatin-induced nephrotoxicity and oxidative stress in rats

Ademiluyi

Oboh

Agbebi

et al. 2014

Pharmaceutical Biology

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Context: Sorghum straw (dried leaves and stem fiber) extracts and infusion are employed in the management of several ailments in folklore, and it is also a natural dye source used in food preparation.Objective: This study sought to investigate the modulatory effect of dietary inclusion of Sorghum straw dye on cisplatin-induced nephrotoxicity and antioxidant status in rats. Materials and methods: Adult male rats were randomly divided into four groups of six animals each. Groups I (normal rats) and II (control rats) were fed with basal diet while Groups III and IV were fed with diets containing 0.5% and 1% sorghum straw dye, respectively. Nephrotoxicity was induced in Groups I-IV on the 20th day by the administration of a single dose of cisplatin solution (7 mg/kg body weight, i.p.) and the experiment was terminated 3 d after. Thereafter, the kidney and plasma of the rats were analyzed for kidney function (creatinine, urea, uric acid, and blood urea nitrogen) and antioxidant indices [superoxide dismutase (SOD), catalase, glutathione-S-transferase (GST), malondialdehyde (MDA), vitamin C, and reduced glutathione (GSH)]. Results: The average feed intake of the rats in all the groups ranged from 9.0 to 9.5 (g/rat/day). Furthermore, the result indicated that administration of cisplatin caused significant (p50.05) elevation in plasma creatinine (2.2 mg/dL), uric acid (39.3 mg/dL), urea (81.4 mg/dL), and blood urea nitrogen (38.0 mg/dL) as well as a concomitant decrease in kidney antioxidant indices in control rats as against the normal rats. However, diets supplemented with 0.5 and 1.0% sorghum straw dye significantly reversed the plasma creatinine and the kidney antioxidant indices to near normal levels. Discussion and conclusion: The study suggests that dietary inclusion of sorghum straw dye as colorants could protect against oxidative stress and cisplatin-induced nephrotoxicity.

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“…Therapeutic effects of cisplatin are dose dependent. Nevertheless, the significant adverse reactions of cisplatin are associated with high dose cisplatin therapy including renal damage, gastrointestinal dysfunction, auditory toxicity, peripheral nerve toxicity and kidney dysfunction [3]. Previous studies have shown that accumulation of cisplatin in tubular cells was 5 times more than that in other tissues, suggesting a major and severe nephrotoxicity [4].…”

Section: Introductionmentioning

confidence: 99%

Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice

Liu

Leng

et al. 2018

Biomedicine & Pharmacotherapy

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Oral administration of caffeic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine

Cited by 34 publications

References 38 publications

Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Dietary inclusion of sorghum (Sorghum bicolour) straw dye protects against cisplatin-induced nephrotoxicity and oxidative stress in rats

Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice

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