Oral Administration of Chlorophyll Fractions for Body Deodorization

Montgomery, Royal M.; Nachtigall, Henry B.

doi:10.1080/00325481.1950.11694031

Cited by 5 publications

(5 citation statements)

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“…This study examined the response of HCT116 human colon cancer cells to treatment with a chlorophyll derivative (chlorophyllin), demonstrating its high effectiveness as a chemo-preventive agent [36]. Due to its high deodorant capacity, chlorophyll a is also used as an ingredient in items of personal hygiene, such as deodorants, or, as pastilles, it is commercialized in formulations against bad breath [68].…”

Section: Chlorophyllsmentioning

confidence: 99%

Microalgae as versatile cellular factories for valued products

Koller

Muhr

Braunegg³

2014

Algal Research

512

307

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Section: Chlorophyllsmentioning

confidence: 99%

Microalgae as versatile cellular factories for valued products

Koller

Muhr

Braunegg³

2014

Algal Research

512

307

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“…[15]. Studies have shown that CHL has immunostimulatory, anti-inflammatory and antiviral effects too [14] [16]. It increases the expression of a transcription factor (protein) Nrf2 which improves lymphocyte survival and enables efficient detoxification after exposure to radiation, along with delayed microtubule polymerization and mitotic spindling -also mitigating radiation damage.…”

Section: Introductionmentioning

confidence: 99%

“…It increases the expression of a transcription factor (protein) Nrf2 which improves lymphocyte survival and enables efficient detoxification after exposure to radiation, along with delayed microtubule polymerization and mitotic spindling - also mitigating radiation damage. It also ameliorates radiation-induced toxicity in normal hematopoietic tissues and epithelial cells [16]. However, chlorophyllin accentuates the radiation-induced killing of human breast cancer cells in xenograft tumour-bearing SCID mice [17].…”

Section: Introductionmentioning

confidence: 99%

Phase II Randomized Study of Short Course Radiotherapy Total Neo-adjuvant Therapy with or without Chlorophyllin in Reducing the Incidence of >/=Grade 2 Acute Toxicity in Advanced Rectal Cancer patients Suitable for Wait and Watch

Krishnatry,

Gota,

Chakraborty

et al. 2024

Preprint

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Background Total Neoadjuvant treatment (TNT) comprising short-course radiotherapy (SCRT) and induction chemotherapy is one of the standard treatment options for locally advanced rectal cancer (LARC). The addition of localised radiotherapy boost dose using techniques such as brachytherapy can improve local tumour control and organ preservation, in selected good responder patients. Overall increased risk of acute treatment-related toxicity rates with TNT approaches can be a deterrent to compliance, treatment completion and overall outcomes. This phase II study is to evaluate, if the addition of Chlorophyllin to this approach, can reduce the burden of grade 2 or higher acute toxicity – Gastrointestinal (GI)/ Genito-urinary (GU)/ haematological toxicity and the rate of overall complete response (clinical and pathological) in well-selected wait and watch suitable locally advanced rectal cancer patients. Aims We aim to evaluate the utility of adding chlorophyllin to SCRT-based TNT interdigitated with brachytherapy as applicable in reducing the incidence of grade 2 or higher acute GI/GU/haematological toxicity in advanced rectal cancer along with estimating the rates of complete clinical responses (pathological + clinical) at the end of two years (2-year overall complete response rates). We will be also estimating organ preservation rates, TME-free survival, Disease-free survival, Distant metastasis-free survival, Loco-regional failure-free survival, and Overall survival, along with toxicities and Quality of Life outcomes as secondary objectives. Methods The study is a 2-arm, phase II, prospective, randomized, double-blind, placebo-controlled superiority study evaluating the clinical outcome - local tumour response, the feasibility of non-operative management (NOM) with hypofractionated dose-escalated radiotherapy, and benefit of Chlorophyllin in reducing toxicity for total neoadjuvant treatment-TNT strategy including short-course radiotherapy and chemotherapy interdigitated with brachytherapy boost for rectal cancer patients. NOM or TME surgery will be followed based on response to NAT as standard treatment in both arms. After accrual and informed consent of eligible LARC patients, there will be: Arm 1 to receive chlorophyllin, and Arm 2 will receive a matching placebo. Permuted block randomisation with a variable block size will be used to randomize 76 (38 in each arm), providing 80% power and a two-sided alpha of 10% to test an absolute reduction in >grade 2 GU/GI/Haematological toxicity rates by 30% (from 70% to 40%) with an anticipated dropout of 10%. It will also provide an estimate for NOM and organ preservation success rates. The current sample size is adequate for the estimated overall response rate at 2 years to be 50% compared to pCR of 28% (est. 95% CI: 24% - 32%) as reported in the RAPIDO study. Discussion We anticipate that with improved logistics of SCRT, better compliance to TNT and improved NOM rates with endorectal brachytherapy boost could be achieved with Chylorophyllin by ameliorating acute treatment-related GI/GU /Haematological toxicity rates. Improved NOM rates and lesser toxicity would result in superior QoL and improved therapeutic ratio compared to the usual high toxicity noticed in standard SCRT-based TNT strategies and TME employed globally.

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“…This pigment can be used as a food ingredient (E140), 11 in hygiene products as a deodorant, and in medical applications as a chemopreventive agent. 6,12,13 The industrial cultivation of cyanobacteria is already taking place worldwide. However, its production is presently focused on a (too) short list of species (e.g., Arthrospira sp., Aphanizomenon sp., Nostoc sp.)…”

Section: Introductionmentioning

confidence: 99%

“…Like phycocyanin, chlorophyll a (Chl a ) is a pigment that absorbs the light (mainly in the blue zone and, to a minor extent, in the red zone) of the electromagnetic spectrum. This pigment can be used as a food ingredient (E140), 11 in hygiene products as a deodorant, and in medical applications as a chemo‐preventive agent 6,12,13 …”

Section: Introductionmentioning

confidence: 99%

Are cyanobacteria a nearly immortal source of high market value compounds?

Macário

Veloso

Fernandes

et al. 2022

J of Chemical Tech & Biotech

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BACKGROUND: When the human population increases, so does the need to explore a wider range of feedstocks and biomasses, such as cyanobacteria. However, a deeper understanding of the growth patterns and pigment production is required to support the selection of the most beneficial species and conditions for industrial production. The growth and pigment production (i.e., chlorophyll a and C-phycocyanin) of three cyanobacterium species were evaluated following a three-fold aim. The first goal was to compare among a species commonly selected for exploitation (Arthrospira platensis) and two alternative species (Anabaena cylindrica and Nostoc muscorum). The second goal was analyzing pigment production in the long-term. The last goal involved comparing different methods (spectrophotometry and fluorimetry) to understand whether there is an appropriate proxy of biomass increase and pigment production that can be used for monitoring purposes. RESULTS: All species showed high longevity and proved capable of growing for more than 100 days without any additional supplementation. However, the maximum quantum yield of PS II (F v /F m ) revealed that their photosynthetic efficiency varied over time with a clear decrease after 2 months. Pigment analysis showed a heterogeneous pattern during the growth periods of all three species that could only be captured by the parameter F v /F m , but the pattern was only present for A. cylindrica and N. muscorum in some stages of the culture period. CONCLUSION: N. muscorum was found to be the best chlorophyll a and C-phycocyanin producer, with the production peaking for all species at defined time periods within the growth profile.

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Oral Administration of Chlorophyll Fractions for Body Deodorization

Cited by 5 publications

References 1 publication

Microalgae as versatile cellular factories for valued products

Microalgae as versatile cellular factories for valued products

Phase II Randomized Study of Short Course Radiotherapy Total Neo-adjuvant Therapy with or without Chlorophyllin in Reducing the Incidence of >/=Grade 2 Acute Toxicity in Advanced Rectal Cancer patients Suitable for Wait and Watch

Are cyanobacteria a nearly immortal source of high market value compounds?

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