Oral Administration of Diferuloylmethane (Curcumin) Suppresses Proinflammatory Cytokines and Destructive Connective Tissue Remodeling in Experimental Abdominal Aortic Aneurysms

Parodi, F. Ezequiel; Mao, Dongli; Ennis, Terri L.; Pagano, Monica B.; Thompson, Robert W.

doi:10.1007/s10016-006-9054-7

Cited by 58 publications

(27 citation statements)

References 47 publications

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“…It is well documented that the protective effect of curcumin from cardiovascular disease occurs through the inhibition of JNK (13,15,32,49). Consistent with these findings, we also demonstrated that C66, accompanied with inhibition of JNK, is able to reduce the high glucose-induced inflammatory changes seen in the diabetic kidney (29).…”

Section: Discussionsupporting

confidence: 79%

Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression

Wang

Zhou

Sun

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

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Section: Discussionsupporting

confidence: 79%

Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression

Wang

Zhou

Sun

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

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“…In diabetic rats, curcumin inhibited nuclear factor-κB (NFκB) and prevented the pathological elevation of interleukin (IL)-1β [5]. Mononuclear inflammation of aortic walls was reduced in a mouse model of cardiovascular disease with curcumin treatment and corresponded with lower tissue concentrations of IL-1β, IL-6, and monocyte chemoattractant protein (MCP)-1 as well as decreased NFκB DNA-binding [6]. Additionally, Toll-like receptor (TLR) 4-induced NFκB activation was inhibited by curcumin in an experimental model of colitis [7] and mild improvement of disease has been observed in several pilot studies in humans with inflammatory bowel disease [8], [9].…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration

Young¹,

Bruss²,

Gardner³

et al. 2014

PLoS ONE

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Despite the widespread use of curcumin for centuries in Eastern medicine as an anti-inflammatory agent, its molecular actions and therapeutic viability have only recently been explored. While curcumin does have potential therapeutic efficacy, both solubility and bioavailability must be improved before it can be more successfully translated to clinical care. We have previously reported a novel formulation of nano-emulsion curcumin (NEC) that achieves significantly greater plasma concentrations in mice after oral administration. Here, we confirm the immunosuppressive effects of NEC in vivo and further examine its molecular mechanisms to better understand therapeutic potential. Using transgenic mice harboring an NFκB-luciferase reporter gene, we demonstrate a novel application of this in vivo inflammatory model to test the efficacy of NEC administration by bioluminescent imaging and show that LPS-induced NFκB activity was suppressed with NEC compared to an equivalent amount of curcumin in aqueous suspension. Administration of NEC by oral gavage resulted in a reduction of blood monocytes, decreased levels of both TLR4 and RAGE expression, and inhibited secretion of MCP-1. Mechanistically, curcumin blocked LPS-induced phosphorylation of the p65 subunit of NFκB and IκBα in murine macrophages. In a mouse model of peritonitis, NEC significantly reduced macrophage recruitment, but not T-cell or B-cell levels. In addition, curcumin treatment of monocyte derived cell lines and primary human macrophages in vitro significantly inhibited cell migration. These data demonstrate that curcumin can suppress inflammation by inhibiting macrophage migration via NFκB and MCP-1 inhibition and establish that NEC is an effective therapeutic formulation to increase the bioavailability of curcumin in order to facilitate this response.

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“…Recently, the curcumin has been reported to reduce aneurysmal degeneration (Parodi et al., 2006). However, the mechanism of curcumin action on cerebral aneurysm yet to be investigated.…”

Section: Discussionmentioning

confidence: 99%

“…In Chinese traditional medicine, the curcumin has been used to treat mental stress and hypochondriac distensive mania and pain. The development of aneurysms has been reduced following curcumin treatment (Parodi, Mao, Ennis, Pagano, & Thompson, 2006). Curcumin has been reported to act against ischemia reperfusion injury (Fiorillo et al., 2008) and dopaminergic neuronal cell death (Yu et al., 2010).…”

Section: Introductionmentioning

confidence: 99%

A study on effect of curcumin on anticerebral aneurysm in the male albino rats

Miao

Wang

et al. 2017

Brain and Behavior

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IntroductionThis study investigated the curcumin effect on the cerebral aneurysm. Apoptosis is known to play a fundamental role in the pathogenesis of a cerebral aneurysm. Therefore, we investigated the effect of curcumin on apoptosis of smooth muscle cells of a cerebral aneurysm‐induced male albino rats.MethodsIn this study, the cerebral aneurysm has been induced in the male albino rats by the CaCl2 administration. After cerebral aneurysm induction, smooth muscle cells were isolated. Cells were treated with curcumin (25 & 50 mg/kg bwt) for 48 hr.ResultsCurcumin reduced altered mitochondrial morphology significantly, evidenced through fluorescence and confocal study. Curcumin treatment reduced the expression of p53, caspase‐3, and bax/bxl‐2 ratio significantly. Curcumin treatment also reversed the cellular architecture of smooth muscle cell wall significantly. Fluorescence and the confocal study confirmed the reduction in apoptosis in a cerebral aneurysm‐induced smooth muscle cells of male albino rats.ConclusionTaking all these data together, it may suggest that the curcumin could significantly reduce the CaCl2‐induced cerebral aneurysm through the inhibition of cell apoptosis in the cells.

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Oral Administration of Diferuloylmethane (Curcumin) Suppresses Proinflammatory Cytokines and Destructive Connective Tissue Remodeling in Experimental Abdominal Aortic Aneurysms

Cited by 58 publications

References 47 publications

Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression

Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression

Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration

A study on effect of curcumin on anticerebral aneurysm in the male albino rats

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