Oral administration of fermented milk supplemented with synbiotics can influence the physiological condition of Wistar rats in a dose-sensitive and sex-specific manner

Miao, Junjie; Lang, Chunhui; Kang, Zhen; Hong, Zhu; Wang, Shijie; Li, Ming

doi:10.12938/bmfh.2015-013

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…The effect of goat milk kefir on parameter of RBC in this study different with a previous study that fermented milk supplemented with probiotics (Bifidobacterium lactis Bi-07 and Lactobacillus acidophilus NCFM and a prebiotic (isomaltooligosaccharide) showed significantly different on HGB in rats compared with the control group [31]. However, the result of the present study was similar with a study by Rosa [19] that kefir had no effect on HCT in normal rats.…”

Section: Discussionsupporting

confidence: 85%

Goat Milk Kefir Supplemented with Porang Glucomannan Improves Lipid Profile and Haematological Parameter in Rat Fed High Fat and High Fructose Diet

Nurliyani

Harmayani

Sunarti

2018

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Background and Aims: Diet with a high fat and high sugar is associated with an increased incindence of the metabolic syndrome. Kefir has been known as a natural probiotic, while glucomannan from porang (Amorphophallus oncophyllus) tuber was demonstrated as prebiotic in vivo. Probiotics and prebiotics can be used adjuvant nutritional therapy for metabolic syndrome. The aim of this study was to evaluate the effect of goat milk kefir supplemented with porang glucomannan on the lipid profile and haematological parameters in rats fed with a high-fat/high-fructose (HFHF) diet.Materials and methods: Rats were divided into 5 groups: normal diet; HFHF; HFHF + kefir; HFHF + kefir + glucomannan; and HFHF + simvastatin.Results: There were significant differences before and after treatment in triglycerides and total cholesterol in HFHF + kefir+glucomannan group. The HFHF rats administered kefir with or without glucomannan had higher levels of lymphocytes and lower neutrophils compared to HFHF group (p<0.05). Only goat milk kefir without glucomannan proved to reduce platelets number.Conclusion: Goat milk kefir supplemented with porang glucomannan could improve the health of rats fed high-fat/high-fructose, by decreasing plasma triglycerides, total cholesterol, and their immunomodulatory effect by decreasing number of neutrophils and increasing the lymphocytes. Especially for goat milk kefir had antithrombotic activity which important to prevent cardiovascular diseases.

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Section: Discussionsupporting

confidence: 85%

Goat Milk Kefir Supplemented with Porang Glucomannan Improves Lipid Profile and Haematological Parameter in Rat Fed High Fat and High Fructose Diet

Nurliyani

Harmayani

Sunarti

2018

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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“…The present finding for serum triglyceride is in agreement with findings of AL-Kehayaz (2015) and Halaby et al (2015) who reported decrease in serum triglyceride level on feeding yoghurt and fermented milk (Miao et al, 2016) to rats. Kawase et al(2000) reported a decrease of triglyceride levels in humans when fed with combined supplementation of Lactobacillus casei and Streptococcusthermophilus.…”

Section: Cholesterol and Triglyceridesupporting

confidence: 93%

Assessment of impact of feeding fermented karonda (Carissa carandas) whey beverage on biochemical parameters of albino rats

Sawant

Chandra

Yadav

2017

IJAR

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The present study was conducted to evaluate the impact of feeding fermented karonda whey beverage(FKWB) on biochemical parameters of albino rats. A total of 24 albino rats (male) of age 28±3 days and weighing 80 to 95 gm were randomly divided into four groups (n=6) and assigned to experimental dietary treatment. Experimental groups consisted of control group fed with basal ration only and groups fed with basal ration containing 10%, 20% and 30% FKWB. Results showed that levels of BUN, creatinine, SGOT, SGPT were significantly (p>0.05) lower in FKWB fed groups, signifying positive impact of FKWB on functioning of kidney and liver. FKWB consumption had no significant (p>0.05) effect on cholesterol and protein levels, while its consumption reduced triglyceride level.

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“…reuteri inhibited TNF-α mRNA in jejunum and ileum of male mice, but not in female mice [ 37 ]. In another study, fermented milk supplemented with synbiotics altered the nutritional index of the rats and these changes were more prominent in female rats [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Probiotics reduce repeated water avoidance stress-induced colonic microinflammation in Wistar rats in a sex-specific manner

et al. 2017

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The colonic response to stress is greater in female rats than in male rats. The aim of this study was to evaluate the effect of probiotics in the repeated water avoidance stress (rWAS)-induced colonic microinflammation model of Wistar rats in a sex-specific manner. The three groups (no-stress, WAS, and WAS with probiotics) were exposed to r-WAS for 1 h daily for 10 days, and Lactobacillus farciminis was administered by oral gavage for 10 days to animals in the probiotics group. The visceromotor response (VMR) to colorectal distension (CRD) was assessed using a barostat and noninvasive manometry before and after WAS exposure. Immunohistochemistry for mast cells and real-time polymerase chain reaction (RT-PCR) for detection of mucosal cytokines were performed using distal colon tissue after the animals were sacrificed. Significant reduction of VMR to CRD (visceral analgesia) was observed at 60 mmHg in the female WAS group (P = 0.045), but not in males. In addition, the female WAS with probiotics group showed a significantly lower colonic mucosal mast cell count in comparison to the female WAS group (P = 0.013), but this phenomenon was not observed in the male group. The colonic mucosal mRNA levels of interferon-γ (IFNR), tumor necrosis factor-α (TNFA), interleukin (IL) 6, and IL17 were higher in the female WAS group than in the male WAS group. The mRNA levels of IFNR, TNFA, and IL6 were significantly decreased in WAS females who received probiotics (all P < 0.050). In conclusion, rWAS is induced in a sex-specific manner. A 10-day-long treatment with L. farciminis is an effective therapy for rWAS-induced colonic microinflammation in female rates, but not in male rats.

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Oral administration of fermented milk supplemented with synbiotics can influence the physiological condition of Wistar rats in a dose-sensitive and sex-specific manner

Cited by 7 publications

References 44 publications

Goat Milk Kefir Supplemented with Porang Glucomannan Improves Lipid Profile and Haematological Parameter in Rat Fed High Fat and High Fructose Diet

Goat Milk Kefir Supplemented with Porang Glucomannan Improves Lipid Profile and Haematological Parameter in Rat Fed High Fat and High Fructose Diet

Assessment of impact of feeding fermented karonda (Carissa carandas) whey beverage on biochemical parameters of albino rats

Probiotics reduce repeated water avoidance stress-induced colonic microinflammation in Wistar rats in a sex-specific manner

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