Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage

Abstract

The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice than in sham-operated mice (p < 0.05). The erythema intensity and epidermal thickness of dorsal skin were significantly lower in the fermented soymilk diet group than in the control diet group (each p < 0.05). Levels of cyclobutane pyrimidine dimers in dorsal skin were significantly lower in the fermented soymilk diet group than in the control group (p < 0.05). Serum and dorsal skin isoflavone concentrations were significantly higher in the fermented soymilk diet group than in the soymilk diet group (p < 0.05). These results indicate that oral administration of a fermented soymilk diet increases isoflavone concentrations in the blood and skin, effectively scavenging the reactive oxygen species generated by UV irradiation and exerting an estrogen-like activity, with a consequent protective effect on skin photodamage in hairless mice.

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

“…Interestingly, the research team of Kano investigated protective effect of isoflavones from fermented soymilk products on photodamage in the skin of ovariectomized hairless by oral administration for 28 days. The results indicated the increases of isoflavone concentration on mice skin and in their blood can effectively scavenge reactive oxygen species generating by UV irradiation, and also exerting estrogenic activity, resulting in photoprotective effect on skin of the animal model [ 94 ].…”

Efficacy of topical soy Isoflavonoid extract in prevention and reversal of photo-ageing in guinea pig model

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“…The isoflavone levels were increased in dorsal skin and serum in fermented soymilk supplemented mice compared to control. The study claimed that the supplementation of fermented soymilk protects the skin from UV irradiation and photo-damage in experimental hairless mice (Kano et al, 2016). B. breve Yakult and L. mali mediated fermented soymilk consumption improve facial wrinkles in healthy women.…”