Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17

Mikami, Ayane; Ogita, Tasuku; Namai, Fu; Shigemori, Suguru; Sato, Takashi; Shimosato, Takeshi

doi:10.3389/fnut.2020.610946

Cited by 34 publications

(28 citation statements)

References 57 publications

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“…Additionally, an elevation of genus Flavonifractor was associated with depression, symptom severity, or worse physical functioning, with no contradictory results [ 42 , 44 , 48 , 64 , 77 ]. Even though Flavonifractor plautii was recently found to suppress the immune response in mice in multiple studies conducted by the same research group [ 101 , 102 , 103 ], it was repeatedly associated with several diseases, including ulcerative colitis, autoimmune diseases, obesity, and even with a poor diet [ 104 , 105 ]. Our findings of elevated Flavonifractor , with no study finding opposite results, strongly support its negative influence on the host’s health, including affective disorder.…”

Section: Resultsmentioning

confidence: 99%

The Role of the Gut Microbiota in the Development and Progression of Major Depressive and Bipolar Disorder

Knuesel

Mohajeri

2021

Nutrients

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A growing number of studies in rodents indicate a connection between the intestinal microbiota and the brain, but comprehensive human data is scarce. Here, we systematically reviewed human studies examining the connection between the intestinal microbiota and major depressive and bipolar disorder. In this review we discuss various changes in bacterial abundance, particularly on low taxonomic levels, in terms of a connection with the pathophysiology of major depressive and bipolar disorder, their use as a diagnostic and treatment response parameter, their health-promoting potential, as well as novel adjunctive treatment options. The diversity of the intestinal microbiota is mostly decreased in depressed subjects. A consistent elevation of phylum Actinobacteria, family Bifidobacteriaceae, and genus Bacteroides, and a reduction of family Ruminococcaceae, genus Faecalibacterium, and genus Roseburia was reported. Probiotics containing Bifidobacterium and/or Lactobacillus spp. seemed to improve depressive symptoms, and novel approaches with different probiotics and synbiotics showed promising results. Comparing twin studies, we report here that already with an elevated risk of developing depression, microbial changes towards a “depression-like” microbiota were found. Overall, these findings highlight the importance of the microbiota and the necessity for a better understanding of its changes contributing to depressive symptoms, potentially leading to new approaches to alleviate depressive symptoms via alterations of the gut microbiota.

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Section: Resultsmentioning

confidence: 99%

The Role of the Gut Microbiota in the Development and Progression of Major Depressive and Bipolar Disorder

Knuesel

Mohajeri

2021

Nutrients

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“…In this context, in addition to the existing lactic acid bacteria and Bifidobacterium , a wider range of microorganisms are expected to be used in the future, and these microorganisms are referred to as next-generation probiotics ( 34 ). For example, it was reported that Flavonifractor plautii , a bacterium isolated from human intestine, improved inflammation ( 35 , 36 ) and allergic immune responses ( 37 ). In addition, in recent studies, genetically modified lactic acid bacteria have been constructed to attenuate cancer ( 38 ), inflammation ( 39 , 40 ), obesity ( 41 ), and allergy ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

A Soybean Resistant Protein-Containing Diet Increased the Production of Reg3γ Through the Regulation of the Gut Microbiota and Enhanced the Intestinal Barrier Function in Mice

et al. 2021

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The maintenance of intestinal homeostasis is necessary for a good quality of life, and strengthening of the intestinal barrier function is thus an important issue. Therefore, we focused on soybean resistant protein (SRP) derived from kori-tofu (freeze-dried tofu), which is a traditional Japanese food, as a functional food component. In this study, to investigate the effect of SRP on the intestinal barrier function and intestinal microbiota, we conducted an SRP free intake experiment in mice. Results showed that ingestion of SRP decreased the serum level of lipopolysaccharide-binding protein and induced the expression of Reg3γ, thereby improving the intestinal barrier function. In addition, SRP intake induced changes in the cecal microbiota, as observed by changes in β-diversity. In particular, in the microbiota, the up-regulation of functional gene pathways related to the bacterial invasion of epithelial cells (ko05100) was observed, suggesting that Reg3γ expression was induced by the direct stimulation of epithelial cells. The results of this study suggest that SRP is a functional food component that may contribute to the maintenance of intestinal homeostasis.

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“…Flavonifractor spp. have also been reported to increase with green tea consumption and promote recovery from acute colitis in mice 44 . Veillonella spp.…”

Section: Discussionmentioning

confidence: 96%

Plant-derived tormentic acid alters the gut microbiota of the silkworm (Bombyx mori)

Bay

Gür

Bayraktar

2022

Sci Rep

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In recent years, phytochemicals have started to attract more attention due to their contribution to health and bioactivity. Microorganisms in the intestines of organisms contribute to the processing, function, and biotransformation of these substances. The silkworm (Bombyx mori) is one of the organisms used for the biotransformation of phytochemicals due to its controlled reproduction and liability to microbial manipulation. In this study, a bioactive compound, tormentic acid (TA), extracted from Sarcopoterium spinosum was used in the silkworm diet, and the alterations of intestinal microbiota of the silkworm were assessed. To do this, silkworms were fed on a diet with various tormentic acid content, and 16S metagenomic analysis was performed to determine the alterations in the gut microbiota profile of these organisms. Diet with different TA content did not cause a change in the bacterial diversity of the samples. A more detailed comparison between different feeding groups indicated increased abundance of bacteria associated with health, i.e., Intestinibacter spp., Flavonifractor spp., Senegalimassilia spp., through the utilization of bioactive substances such as flavonoids. In conclusion, it might be said that using TA as a supplementary product might help ameliorate the infected gut, promote the healthy gut, and relieve the undesirable effects of medicines on the gastrointestinal system.

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Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17

Cited by 34 publications

References 57 publications

The Role of the Gut Microbiota in the Development and Progression of Major Depressive and Bipolar Disorder

The Role of the Gut Microbiota in the Development and Progression of Major Depressive and Bipolar Disorder

A Soybean Resistant Protein-Containing Diet Increased the Production of Reg3γ Through the Regulation of the Gut Microbiota and Enhanced the Intestinal Barrier Function in Mice

Plant-derived tormentic acid alters the gut microbiota of the silkworm (Bombyx mori)

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