Oral administration of green tea Epigallocatechin-3-gallate reduces oxidative stress and enhances restoration of cardiac function in diabetic rats receiving autologous transplantation of adipose-derived stem cells

Chen, Tung-Sheng; Liou, Show-Yih; Lin, Hsin‐Hung; Hung, Min-Nan; Lin, Chien‐Chung; Lin, Yueh‐Min; Lin, Kuan-Ho; Padma, V. Vijaya; Yao, Chun‐Hsu; Kuo, Wei‐Wen; Huang, Chih‐Yang

doi:10.1080/13813455.2019.1614631

Cited by 17 publications

(11 citation statements)

References 33 publications

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“…The previously described beneficial effects obtained with AT-MSC therapy were even greater when preconditioned with resveratrol, which increased cell viability, migration and secretory capacity by upregulating the expression of CXCR4 and proteins related to the antioxidant Sirt 1/Akt axis. They have also shown that the beneficial effects of cell therapy with AT-MSCs were potentiated by the oral administration of green tea epigallocatechin-3-gallate, which has great antioxidant potential [ 123 ].…”

Section: Preclinical and Clinical Approaches To Msc In Diabetes-induced Cardiac Complicationsmentioning

confidence: 99%

Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy

Gonçalves

Vasques

et al. 2022

Cells

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The incidence and prevalence of diabetes mellitus (DM) are increasing worldwide, and the resulting cardiac complications are the leading cause of death. Among these complications is diabetes-induced cardiomyopathy (DCM), which is the consequence of a pro-inflammatory condition, oxidative stress and fibrosis caused by hyperglycemia. Cardiac remodeling will lead to an imbalance in cell survival and death, which can promote cardiac dysfunction. Since the conventional treatment of DM generally does not address the prevention of cardiac remodeling, it is important to develop new alternatives for the treatment of cardiovascular complications induced by DM. Thus, therapy with mesenchymal stem cells has been shown to be a promising approach for the prevention of DCM because of their anti-apoptotic, anti-fibrotic and anti-inflammatory effects, which could improve cardiac function in patients with DM.

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Section: Preclinical and Clinical Approaches To Msc In Diabetes-induced Cardiac Complicationsmentioning

confidence: 99%

Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy

Gonçalves

Vasques

et al. 2022

Cells

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“…EGCG is the most abundant of these catechins, and many healthful benefits, including anticarcinogenic, antioxidant, antiangiogenic, antidiabetic and antiviral activities, have been attributed to EGCG. The consumption of green tea is conscious health benefitable habit, and is the key marker to reduce many of the dangerous impacts with a focus on oxidative and nitrosative stress induced by diabetes [13] as well as by alcohol abuse [14]. EGCG reduced hyperglycaemic condition disturbs all the metabolic pathways directly or indirectly, and also has proven that it ameliorates glucose intolerance [15].…”

Section: Introductionmentioning

confidence: 99%

Possible ameliorative role of green tea on chronic alcohol mediated renal toxicity of STZ -induced diabetic rats

Kodidela

Shaik

Chinta

et al. 2020

Clinical Nutrition Experimental

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Clinical Nutrition Experimental 34 (2020) 1e25 excessive chronic alcohol treatment caused additive deterioration of the kidney function as evidenced by increased inducible nitric oxide synthase (iNOS) protein expression and thus nitroxidative stress and histopathological aberrations leading to aggravation of diabetic nephropathy under alcohol intoxication. Treatment with aqueous green tea extract (300 mg/kg.b.w) to diabetic rats treated with alcohol renders the protection against the decreased body weight, increased hyperglycemia, hyperlipidemia, catecholamines, nitroxidative stress and further tissue damage.

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“…Anti-inflammatory and antifibrotic effects were mediated via the production of prostaglandin E2 by AT-MSCs. Cardioprotective activity of AT-MSCs in diabetic cardiomyopathy is better achieved when cell therapy is combined with oral administration of a flavanol molecule that reduces oxidative stress, enhancing the regenerative potential of AT-MSCs [ 107 ].…”

Section: Msc Therapy In Pre-clinical Models Of Cardiomyopathiesmentioning

confidence: 99%

Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases

Gubert

Vasques

et al. 2021

IJMS

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Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM-MSCs), adipose tissue (AT-MSCs), umbilical cord (UC-MSCs) and placenta. Therapeutic use of MSCs in cardiovascular diseases is based on the benefits in reducing cardiac fibrosis and inflammation that compose the cardiac remodeling responsible for the maintenance of normal function, something which may end up causing progressive and irreversible dysfunction. Many factors lead to cardiac fibrosis and failure, and an effective therapy is lacking to reverse or attenuate this condition. Different approaches have been shown to be promising in surpassing the poor survival of transplanted cells in cardiac tissue to provide cardioprotection and prevent cardiac remodeling. This review includes the description of pre-clinical and clinical investigation of the therapeutic potential of MSCs in improving ventricular dysfunction consequent to diverse cardiac diseases.

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Oral administration of green tea Epigallocatechin-3-gallate reduces oxidative stress and enhances restoration of cardiac function in diabetic rats receiving autologous transplantation of adipose-derived stem cells

Cited by 17 publications

References 33 publications

Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy

Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy

Possible ameliorative role of green tea on chronic alcohol mediated renal toxicity of STZ -induced diabetic rats

Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases

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