Oral Administration of<i>Vaccinium uliginosum</i>L. Extract Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice

Kim, Kang-Hyun; Choung, Se‐Young

doi:10.1089/jmf.2013.3053

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…V. uliginosum extract reduced atopic dermatitis-like skin lesions induced by DNCB, like ear thickness and the frequency of scratching episodes in a time-dependent manner. The extract also reduced epidermal thickening, the infiltration of eosinophils, mast cells, and degranulated mast cells induced by DNCB [ 87 ].…”

Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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During the last 30 years, berries have gained great attention as functional food against several risk factors in chronic diseases. The number of related publications on Pubmed rose from 1000 items in 1990 to more than 11,000 in 2019. Despite the fact that a common and clear definition of “berries” is not shared among different scientific areas, the phytochemical pattern of these fruits is mainly characterized by anthocyanins, flavanols, flavonols, and tannins, which showed antioxidant and anti-inflammatory properties in humans. Skin insults, like wounds, UV rays, and excessive inflammatory responses, may lead to chronic dermatological disorders, conditions often characterized by long-term treatments. The application of berries for skin protection is sustained by long traditional use, but many observations still require a clear pharmacological validation. This review summarizes the scientific evidence, published on EMBASE, MEDLINE, and Scholar, to identify extraction methods, way of administration, dose, and mechanism of action of berries for potential dermatological treatments. Promising in vitro and in vivo evidence of Punica granatum L. and Vitis vinifera L. supports wound healing and photoprotection, while Schisandra chinensis (Turcz.) Baill. and Vaccinium spp. showed clear immunomodulatory effects. Oral or topical administrations of these berries justify the evaluation of new translational studies to validate their efficacy in humans.

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Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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“…This study differs from previous studies with regard to the timing of treatment administration. Previous studies administered the herbal extracts after AD symptom onset [ 27 – 30 ]. On the other hand, this study administered the herbal extracts before clinical symptom onset.…”

Section: Discussionmentioning

confidence: 99%

Hataedock Treatment Has Preventive Therapeutic Effects in Atopic Dermatitis‐Induced NC/Nga Mice under High‐Fat Diet Conditions

Cha

Ahn

Cheon

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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This study investigated the preventive therapeutic effects of Hataedock (HTD) treatment on inflammatory regulation and skin protection in AD-induced NC/Nga mice under high-fat diet conditions. Before inducing AD, the extract of Coptidis Rhizoma and Glycyrrhiza uralensis was administered orally to the 3-week-old mice. After that, AD-like skin lesions were induced by applying DNFB. All groups except the control group were fed a high-fat diet freely. We identified the effects of HTD on morphological changes, cytokine release and the induction of apoptosis through histochemistry, immunohistochemistry, and TUNEL assay. HTD downregulated the levels of IL-4 and PKC but increased the levels of LXR. HTD also suppressed the mast cell degranulation and release of MMP-9, Substance P. The levels of TNF-α, p-IκB, iNOS, and COX-2 were also decreased. The upregulation of inflammatory cell's apoptosis is confirmed by our results as increase of apoptotic body and cleaved caspase-3 and decrease of Bcl-2. HTD also reduced edema, angiogenesis, and skin lesion inflammation. Our results indicate HTD suppresses various inflammatory response on AD-induced mice with obesity through the regulation of Th2 differentiation and the protection of lipid barrier. Therefore, HTD could be used as an alternative and preventive therapeutic approach in the management of AD.

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“…The NC / Nga mouse is the first reported spontaneously occurring AD model [7,8] . Skin changes that closely mimic human AD are induced in NC / Nga mice following exposure to hypersensitivity pathogenesis is predominantly the result of T cell mediated immune responses [9,14] . Therefore, DNCB-treated NC / Nga mice have been used as a valuable animal model for screening anti-AD agents [15,16] .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Bifidobacterium Longum Kacc 91563 on Dncb-Induced Atopic Dermatitis-Like Skin Lesions in Nc / Nga Mice

Lee¹

2018

IJFNS

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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by severe itch. This study was designed to evaluate the therapeutic effects of oral administration of Bifidobacterium longum, KACC 91563 (BLK) on 2, 4-dinitrochlorobenzene (DNCB) -induced AD-like skin lesions in NC / Nga mice. Three doses of BLK (333, 1667, and 3334 mg / kg / day, 7 times a week) were orally administrated to mice with DNCB-induced AD. The therapeutic effect of BLK was assessed by measuring skin AD score, scratching behavior, serum IgE levels, as well as the expression of COX-2, TNF-α, IL-4, IL-10, and IL-12 by immunohistochemistry. AD score, scratching frequency, serum IgE level, COX-2, TNF-α, IL-4, IL-10, and IL-12 increased in mice with DNCB-induced AD. BLK alleviated AD-like symptoms such as skin severity of AD score and scratching behaviors. In addition, BLK reduced IgE, COX-2, and TNF-α, IL-4, IL-10, and IL-12 expression. These results suggest that oral administration of BLK has beneficial therapeutic effects for AD patients. Citation:Lee, C.K., et al. Therapeutic Effects of Bifidobacterium Longum Kacc 91563 on Dncb-Induced Atopic Dermatitis-Like Skin Lesions in Nc / Nga Mice. (2018) Int J Food Nutr Sci 5(1): 30-37.

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Oral Administration ofVaccinium uliginosumL. Extract Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice

Cited by 7 publications

References 37 publications

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

Hataedock Treatment Has Preventive Therapeutic Effects in Atopic Dermatitis‐Induced NC/Nga Mice under High‐Fat Diet Conditions

Therapeutic Effects of Bifidobacterium Longum Kacc 91563 on Dncb-Induced Atopic Dermatitis-Like Skin Lesions in Nc / Nga Mice

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