Oral Administration of Lipid-Based Delivery Systems to Combat Infectious Diseases

Pinto, Rita Maria; Lopes, Daniela; Nunes, Cláudia; Sarmento, Bruno; Reis, Salette

doi:10.1201/9781351207355-4

Cited by 2 publications

(4 citation statements)

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“…Antimicrobial drugs are commonly administered through the oral route, with a poor bioavailability and efficacy of drugs (Pinto et al . 2017 ). Additionally, the systemic distribution of antibiotics leads to a lower concentration at the target site.…”

Section: Current Treatment Of Implant-associated S Aureus mentioning

confidence: 99%

“…The efficacy of antimicrobial drugs can also be compromised by intrinsic factors, such as poor cellular penetration, limited intracellular retention, decreased intracellular activity and inefficient subcellular distribution (Pinto et al . 2017 ).…”

Section: Current Treatment Of Implant-associated S Aureus mentioning

confidence: 99%

“…The determination of the minimum inhibitory concentration (MIC) and of the minimum bactericidal concentration (MBC) are key pharmacodynamic parameters to study the efficiency of nanosystems against planktonic bacteria (Pinto et al . 2017 ). On the other hand, to assess the efficacy of nanosystems against bacteria within a biofilm structure, minimum biofilm inhibitory concentration (MBIC) and the minimum biofilm eradication concentration (MBEC) are used (Macia, Rojo-Molinero and Oliver 2014 ).…”

Section: Nanosystems Preclinical Validation: Biofilm Modelsmentioning

confidence: 99%

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Impact of nanosystems in Staphylococcus aureus biofilms treatment

Pinto

Lopes

Martins

et al. 2019

FEMS Microbiology Reviews

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Staphylococcus aureus (S. aureus) is considered by the World Health Organization as a high priority pathogen for which new therapies are needed. This is particularly important for biofilm implant-associated infections once the only available treatment option implies a surgical procedure combined with antibiotic therapy. Consequently, these infections represent an economic burden for Healthcare Systems. A new strategy has emerged to tackle this problem: for small bugs, small particles. Here, we describe how nanotechnology-based systems have been studied to treat S. aureus biofilms. Their features, drawbacks and potentialities to impact the treatment of these infections are highlighted. Furthermore, we also outline biofilm models and assays required for preclinical validation of those nanosystems to smooth the process of clinical translation.

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Section: Current Treatment Of Implant-associated S Aureus mentioning

confidence: 99%

Section: Current Treatment Of Implant-associated S Aureus mentioning

confidence: 99%

Section: Nanosystems Preclinical Validation: Biofilm Modelsmentioning

confidence: 99%

See 1 more Smart Citation

Impact of nanosystems in Staphylococcus aureus biofilms treatment

Pinto

Lopes

Martins

et al. 2019

FEMS Microbiology Reviews

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“…Nanoparticles (NP), the diameter of which is in the range from 1 to 100 nm, are materials that have revolutionized many industries in the last decade [1,2]. Nanotechnology has become a new branch of science that deals with the construction of nanoparticles, and its achievements are also used in pharmacy and medicine [3]. In molecular diagnostics [4], the use of nanoparticles enables detection of cancerous tumors at their early stages of development and faster implementation of therapy.…”

Section: Introductionmentioning

confidence: 99%

New Supramolecular Drug Carriers: The Study of Organogel Conjugated Gold Nanoparticles

et al. 2021

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An aqueous solution of sodium citrate stabilized gold nanoparticles (AuNP) in the presence of N-lauroyl-L-alanine (C12ALA) forms a stable gel. The structure of the gel and the distribution profile of AuNP in it were analyzed. Will nanoparticles separated from each other with sodium citrate behave in the same way in solution and trapped in the gel matrix? Will the spatial limitation of solvent molecules aggregate nanoparticles and destroy their homogeneity? These questions are very important from the point of view of the use of gold nanoparticles, trapped in the gel structure as carriers of drugs in the slow-release process. The lack of homogeneity of this distribution will have a major impact on the rate of release of the appropriate amount of therapeutic drug from the matrix. In this work, we attempt to answer these questions. The performed biological assays revealed that both C12ALA and C12ALA-AuNP show an excellent level of biological neutrality. They might be used as a transporting medium for a drug delivery without affecting the drug’s activity.

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Oral Administration of Lipid-Based Delivery Systems to Combat Infectious Diseases

Cited by 2 publications

References 1 publication

Impact of nanosystems in Staphylococcus aureus biofilms treatment

Impact of nanosystems in Staphylococcus aureus biofilms treatment

New Supramolecular Drug Carriers: The Study of Organogel Conjugated Gold Nanoparticles

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