Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats

Zhang, Zhaofeng; Wang, Junbo; Ding, Ye; Dai, Xiaoqian; Li, Yong

doi:10.1002/jsfa.4435

Cited by 60 publications

(60 citation statements)

References 31 publications

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“…Our current findings confirm previous reports from experimental and animal trials demonstrating the stimulatory effects of collagen peptides on anabolic processes supporting the maintenance of the dermis extracellular matrix [6,7,8,9,20]. Our in vitro studies on primary human dermal fibroblasts demonstrated a stimulatory effect of Verisol® on the expression of skin extracellular matrix macromolecules.…”

Section: Discussionsupporting

confidence: 91%

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Proksch

Schunck²,

Zague³

et al. 2013

Skin Pharmacol Physiol

128

110

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Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis.

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Section: Discussionsupporting

confidence: 91%

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Proksch

Schunck²,

Zague³

et al. 2013

Skin Pharmacol Physiol

128

110

View full text Add to dashboard Cite

show abstract

“…This is a special staining for collagen fibers that makes their color blue. Then, based on the intensity of blue color (Zhang et al, 2011), scaling was numbered as follows; 1: rare, 2: minimal, 3: moderate, 4: marked, 5: high marked.…”

Section: Histological Evaluationmentioning

confidence: 99%

Pharmaceutical application of frog skin on full-thickness skin wound healing in mice

Bazaz¹,

Mashreghi²,

SHahri³

et al. 2013

Pharmaceutical Biology

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Context: It has been proved that fresh frog skin is efficient in the wound healing process. Objective: The purpose of study is to introduce a formulation of frog skin powder for evaluation of wound repair where fresh frog skin is not available. Materials and methods: Rana ridibunda (Ranidae) skins were lyophilized, and a powder was prepared. The powder (0.0005 g) was then mixed with ointment (0.0065 g) for treating each wound. Formulation was used on full-thickness wounds on mice (FO group) and compared to positive and negative controls. In order to study the wound healing process, wound contraction, inflammation, number of fibroblast cells, neovascularization and collagen density were evaluated on days 2, 4 and 6 following the injury. Moreover, CFU measurement was performed for the evaluation of wound contamination. Results: Acceleration in wound contraction in the FO group compared to control groups was significant (p50.001) on days 4 and 6. Results showed that FO treatment considerably decreased inflammatory cells during the study. On day 4, FO treatment was significantly effective in increasing the number of fibroblast cells and collagen density (p50.01 and p50.05, respectively). On day 6 the number of fibroblast cells (p50.001), collagen density (p50.05) and neovascularization (p50.05), were higher in the FO group than the control groups. Results of CFU measurement demonstrated significant reduction of wound contamination in FO treated wounds on days 2 (p50.05) and 4 (p50.01). Discussion and conclusion: Our findings indicated that the pharmaceutical form of frog skin used in this study has considerable healing and antibacterial effects on wounds.

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“…Due to the special marine ecological environment, such as high pressure, low temperature and high salinity, MCPs from marine fishes differ greatly from those from terrestrial livestock in both physicochemical properties and amino acid compositions, and have unique physiological functions including antibacterial [19], antioxidant [16,20], antihypertensive [21,22,23], neuroprotective [24] and anti-skin-aging activities [25]. It was reported that oral administration of marine collagen peptides from Chum Salmon ( Oncorhynchus keta ) skin enhanced cutaneous wound healing and angiogenesis in rats [26]. Most recently, the electrospun tilapia collagen nanofibers which could accelerate skin wound healing rapidly and effectively in the rat model were developed [27].…”

Section: Introductionmentioning

confidence: 99%

Marine Collagen Peptides from the Skin of Nile Tilapia (Oreochromis niloticus): Characterization and Wound Healing Evaluation

et al. 2017

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Burns can cause tremendous economic problems associated with irreparable harm to patients and their families. To characterize marine collagen peptides (MCPs) from the skin of Nile tilapia (Oreochromis niloticus), molecular weight distribution and amino acid composition of MCPs were determined, and Fourier transform infrared spectroscopy (FTIR) was used to analyze the chemical structure. Meanwhile, to evaluate the wound healing activity, in vitro and in vivo experiments were carried out. The results showed that MCPs prepared from the skin of Nile tilapia by composite enzymatic hydrolysis were composed of polypeptides with different molecular weights and the contents of polypeptides with molecular weights of less than 5 kDa accounted for 99.14%. From the amino acid composition, the majority of residues, accounting for over 58% of the total residues in MCPs, were hydrophilic. FTIR indicated that the main molecular conformations inside MCPs were random coil. In vitro scratch assay showed that there were significant effects on the scratch closure by the treatment of MCPs with the concentration of 50.0 μg/mL. In the experiments of deep partial-thickness scald wound in rabbits, MCPs could enhance the process of wound healing. Therefore, MCPs from the skin of Nile tilapia (O. niloticus) have promising applications in wound care.

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Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats

Abstract: The results show the efficacy of oral MCP treatment on wound healing in animals.

Cited by 60 publications

References 31 publications

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Pharmaceutical application of frog skin on full-thickness skin wound healing in mice

Marine Collagen Peptides from the Skin of Nile Tilapia (Oreochromis niloticus): Characterization and Wound Healing Evaluation

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