Oral administration of milk from cows immunized with human intestinal bacteria leads to significant improvements of symptoms and signs in patients with oral submucous fibrosis

Tai, Yi‐Jou; Liu, B. Y.; Wang, J. T.; Sun, Aihua; Kwan, Hsueh‐Wan; Chiang, Chun-Pin

doi:10.1034/j.1600-0714.2001.301007.x

Cited by 46 publications

(29 citation statements)

References 29 publications

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“…Results of our study were in consonance with various studies done to reduce the burning sensation by administration of Intralesional steroids (89.28%), Intralesional IFN γ 9 (60%), Immunized milk 14 (77.8%), Oxitard capsules 34 (71.6%), Antoxid tablets (86.6%) and Levamisole 35 (98.6%) whereas improved relief was attained when compared to various studies done with pentoxifylline alone. 21,36 Improvement in loco regional blood flow by Pentoxifylline accounts for the significant reduction in burning sensation.…”

Section: Resultssupporting

confidence: 76%

“…2,3 As the etiology of the disease is not singlet, many treatment modalities have been tried and validated in the literature. 4 Steroids, antioxidants, enzymes like collagenase 5 , chymotrypsin 6 , and hyaluronidase 6,7 , placental extracts 8 , Interferon-γ 9 , lycopene 10 , peripheral vasodilators 11,12 , levamisole 13 , immune milk 14 , physiotherapy 15,16 and surgical modalities 17,18,19 have been cited in the literature, yet they have been palliative and proven to be of minimal benefit. Although intralesional steroids have shown improvement, but are associated with significant discomfort, pain and infection at the injection site and reduction in mouth opening over a period of follow-up as rebound fibrosis is often precipitated as mechanical and chemical injuries in the oral mucosa heal by fibrosis.…”

Section: Introductionmentioning

confidence: 99%

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2016

IJPSR

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

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2016

IJPSR

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“…Baseline patterns of areca nut use were reported in 30% of investigations, and those of alcohol and ⁄ or tobacco were reported in 22%. Baseline assessment of nutritional or dietary habits was reported in a single study (Tai et al, 2001), and laboratory assessment of hematologic status was made in 30% of studies.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

et al. 2011

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Oral submucous fibrosis (OSF) is a chronic, insidious disease caused by areca nut use, and is associated with both significant morbidity (including pain and reduced oral opening) and an increased risk for malignancy. This systematic review explored and updated the current medical (i.e., non-surgical) interventions available for the management of OSF. Of the 27 published medical interventions, there were four randomized controlled trials. The overall quality of these randomized controlled studies was assessed using the GRADE approach and significant limitations that challenged the conclusions were found. However, this review was valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, and the infrastructure required to conduct studies. The next step is to initiate a pathway for a low-cost research plan leading to the development of a brief protocol for future clinical trials in this field, with an emphasis on conducting studies in regions of the world where OSF is prevalent.

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“…Various medical managements have been mentioned in literature. (Table 2) Treatment Treatment details Micronutrients and minerals [10] Vitamin A, B complex, C, D and E, iron, copper, calcium, zinc, magnesium, selenium and others Milk from immunized cows [11] 45 g milk powder twice a day for 3 months Lycopene [12] 8 mg twice a day for 2 months Pentoxyflline [13] 400 mg 3 times a day for 7 months Interferon gamma [14] Intralesional injection of interferon gamma (0.01-10.0 U/mL) 3 times a day for 6 months Steroids [15] Submucosal injections twice a week in multiple sites for 3 months Steroids [15] Topical for 3 months Hyalase + Dexamethasone [15] Placental extracts [15] Turmeric [16] Alcoholic extracts of turmeric (3 g), turmeric oil (600 mg), turmeric oleoresin (600 mg) daily for 3 months Chymotripsin, hyaluronidase and dexamethasone [17] Chymotripsin (5000 IU), hyaluronidase (1500 IU) and dexamethasone (4 mg), twice weekly submucosal injections for 10 weeks Conservative treatment with local steroids, hyaluronidase injections and physiotherapy are not beneficial in advanced cases.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of Oral submucous fibrosis

Cn¹,

Vijayakumar²

2016

Int J of Biomed & Adv Res

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Background: Oral submucous fibrosis (OSF), globally accepted as an Indian disease, has one of the highest rates of malignant transformation amongst potentially malignant oral lesions and conditions. The hallmark of the disease is submucosal fibrosis that affects most parts of the oral cavity, pharynx and upper third of the esophagus leading to dysphagia and progressive trismus due to rigid lips and cheeks. Nonsurgical measures like local steroids, hyaluronidase injections, vitamin supplements and jaw opening exercises have poor results. There lack of guidelines for choosing the surgical procedures. Methods: This prospective study was done on 13 cases of clinically diagnosed oral submucous fibrosis during 2012-2015. After diagnosis these patients are grouped according to the severity of the disease proposed by Chandramani More. The patients underwent either release and split skin grafting or Nasolabial flap or Superficial temporal artery fascial flap for intra oral cover. The results were analysed for postoperative mouth opening and complications. Results: Of the total 13 patients studied 8 were male and 5 females. The age ranged from 22 years to 68 year (Mean= 43 years). Preoperative functional stage was ten patients 15-25mm mouth opening (M3) and three patient <15mm mouth opening (M4) Mean preoperative mouth opening was 16.7mm. The procedure performed was release with split skin graft in six patients, release with Nasolabial flap cover in two patients and release with superficial temporal artery flap cover with graft in five patients. Mean post operative mouth opening was 35.6mma at follow up of 6 months. Conclusion: Surgical correction of oral submucous fibrosis offer better outcome than conservative management. The choice of surgical procedure depends on patient profile. Flap covers are better than split skin graft in term of recurrances. Nasolabial flap cover can be used in elderly with lax skin. The superficial temporal artery fascial flap cover has advantage of lesser morbidity and more suited in cases of severe restriction of mouth opening.

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Oral administration of milk from cows immunized with human intestinal bacteria leads to significant improvements of symptoms and signs in patients with oral submucous fibrosis

Abstract: We conclude that oral administration of immune milk leads to significant improvements of symptoms and signs in OSF patients.

Cited by 46 publications

References 29 publications

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A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

Surgical management of Oral submucous fibrosis

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