Oral administration of palatinose vs sucrose improves hyperglycemia in normal C57BL/6J mice

Hwang, Dahyun; Park, Hye-Ryung; Lee, Sue Jung; Kim, Han Wool; Kim, Jaehwan; Shin, Kwang‐Soon

doi:10.1016/j.nutres.2018.06.010

Cited by 15 publications

(13 citation statements)

References 29 publications

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“…Gastric enzyme containing pepsin from porcine gastric mucosa and an intestinal enzyme mixture including maltase, sucrose, isomaltase, and glucoamylase were obtained from Sigma‐Aldrich (St. Louis, MO, USA). The gastric and small intestinal enzymes were activated according to a previously reported protocol (Hwang et al, 2018). The activated enzymes were reacted with their respective substrate solutions (1 mg/ml) at 37°C.…”

Section: Methodsmentioning

confidence: 99%

“…The primers for the mouse genes, which are listed in Table 4, were obtained from Bioneer (Seoul, Republic of Korea). The PCR was performed using a previously described method (Hwang et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

“…The membranes were blocked with phosphate‐buffered saline containing 5% skim milk and 0.05% Tween 20 (in PBST) at 4°C for 12 hr. Thereafter, western blotting with the required primary and secondary antibodies was performed in accordance with the method described by Hwang et al (2018). Quantification of the bands was performed using the NIH ImageJ software.…”

Section: Methodsmentioning

confidence: 99%

“…Various beneficial effects of palatinose consumption on postprandial glucose metabolism have been studied, such as glycemic index (Holub et al, 2010), fat accumulation (Konig, Theis, Kozianowski, & Berg, 2012), hyperglycemia (Maeda et al, 2013), and hyperinsulinemia (Oizumi et al, 2007); these studies suggest that palatinose is a good alternative for sucrose. We also recently demonstrated that oral administration of only palatinose significantly alleviates postprandial hyperglycemia compared to sucrose in normal C57BL/6J mice (Hwang et al, 2018). Unfortunately, despite having desirable biological functions, palatinose has limitations as a complete alternative for sucrose; its disadvantages include higher production costs, lower solubility, and lower sweetness as compared to that of sucrose.…”

Section: Introductionmentioning

confidence: 90%

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Improved effect of palatinose syrup bioconverted from sucrose on hyperglycemia and regulation of hepatic lipogenesis in male C57BL/6J mice

Lee

Park

et al. 2020

J Food Biochem

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In this study, we prepared palatinose–sucrose (PS) mixtures from sucrose by enzymatic bioconversion to improve the low sweetness of palatinose and to develop sweeteners that can lower blood sugar levels. We hypothesized that PS mixtures containing 30% or 50% palatinose might demonstrate improvement of hyperglycemia. The physiological changes in C57BL/6J mice fed with these concentrations of PS mixture were recorded. After feeding the mice the different diets for 5 weeks, the diet with a higher palatinose content was observed to have resulted in lower serum glucose levels. The expression levels of various genes and proteins related to hepatic lipogenesis and cholesterol homeostasis were measured. The diet containing the 50% PS mixture induced lower expression of HMGCR, CYP7A1, and PPARγ as compared to the diet containing the 30% PS mixture. In conclusion, the ingestion of palatinose resulted in lower lipid levels compared to that of sucrose; therefore, palatinose would be a good alternative to sucrose as a healthy sweetener. Practical applications Palatinose (isomaltulose), along with tagatose, allulose, and allose, is a well‐known sugar substitute. Many studies have reported that palatinose has various beneficial effects on postprandial glucose metabolism, such as glycemic index, fat accumulation, hyperglycemia, and hyperinsulinemia. Although there are many advantages, including desirable biological functions, palatinose has limitations as a complete alternative for sucrose because of higher production costs, lower solubility, and lower sweetness. Therefore, we aimed to investigate the possibility of developing a sucrose substitute by preparing PS mixtures bioconverted using α‐glucosyltransferase from sucrose and to promote the industrial application of palatinose. Our results suggest that 50% palatinose syrup may be a new candidate as a sugar substitute for industrial application.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

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Improved effect of palatinose syrup bioconverted from sucrose on hyperglycemia and regulation of hepatic lipogenesis in male C57BL/6J mice

Lee

Park

et al. 2020

J Food Biochem

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“…Unlike saccharose, isomaltulose lowers the glycemic index and shows additional health benefits [ 4 , 5 , 6 ]. Recently, isomaltulose has been shown to improve hyperglycemia in vivo [ 7 ] which has brought about related clinical trials [ 8 , 9 , 10 ]. Isomaltulose can also be found in food and nutrition for diabetics [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid HPLC Method for Determination of Isomaltulose in the Presence of Glucose, Sucrose, and Maltodextrins in Dietary Supplements

Crha

Pazourek

2020

Foods

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This paper presents a rapid HPLC method for the separation of isomaltulose (also known as Palatinose) from other common edible carbohydrates such as sucrose, glucose, and maltodextrins, which are commonly present in food and dietary supplements. This method was applied to determine isomaltulose in selected food supplements for special diets and athletic performance. Due to the selectivity of the separation system, this method can also be used for rapid profiling analysis of mono-, di-, and oligosaccharides in food.

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Isomaltulose: From origin to application and its beneficial properties – A bibliometric approach

Souza

Almeida

Castro

et al. 2022

Food Research International

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Oral administration of palatinose vs sucrose improves hyperglycemia in normal C57BL/6J mice

Cited by 15 publications

References 29 publications

Improved effect of palatinose syrup bioconverted from sucrose on hyperglycemia and regulation of hepatic lipogenesis in male C57BL/6J mice

Improved effect of palatinose syrup bioconverted from sucrose on hyperglycemia and regulation of hepatic lipogenesis in male C57BL/6J mice

Rapid HPLC Method for Determination of Isomaltulose in the Presence of Glucose, Sucrose, and Maltodextrins in Dietary Supplements

Isomaltulose: From origin to application and its beneficial properties – A bibliometric approach

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