Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats

Feng, Cuijiao; Zhang, Weiqin; Zhang, Tao; Li, Bohai; He, Qiuwen; Kwok, Lai‐Yu; Zhang, Heping

doi:10.1016/j.jff.2022.105140

Cited by 18 publications

(34 citation statements)

References 60 publications

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“…The colon tissues of DSS-treated rats also had severe mucosal structure damage, goblet cell depletion, epithelial cell exfoliation, and inflammatory cell infiltration. The results observed in this study were similar to a previous study on probiotic fermented milks improving colitis in rats, 31 indicating that the use of DSS to construct an IBD model could achieve more stable disease symptoms. In contrast, the extent of colonic tissue damage and inflammation were substantially less severe in DSS-treated rats receiving medium and high (0.2 and 0.4 g/kg) doses of postbiotic.…”

Section: Discussionsupporting

confidence: 90%

Postbiotic Administration Ameliorates Colitis and Inflammation in Rats Possibly through Gut Microbiota Modulation

Feng,

Peng,

Zhang

et al. 2024

J. Agric. Food Chem.

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Postbiotics are preparations of inanimate microorganisms and/or their components that are beneficial to host health. Compared with probiotics, the postbiotic dose required for exerting obvious protective effects is unknown. Thus, we conducted a dose-dependent postbiotic intervention study in dextran sulfate sodium (DSS)-induced colitis rats. The trial included five rat groups, including: control without DSS/postbiotic treatment, group C; 7-day DSS treatment, group D; 14-day low, medium, and high probiotic doses (0.1, 0.2, 0.4 g/kg; groups L, M, H, respectively) after DSS induction. We found that postbiotic intervention effectively mitigated the symptoms and inflammation in colitis rats, evidenced by the improved spleen index, less severe colon tissue damage, and changes in serum cytokine levels (decreases in tumor necrosis factor-α and interleukin-1β; increase in interleukin-10) in postbiotic groups compared with group D. Moreover, the therapeutic effect was dose-dependent. Fecal metabolomics analysis revealed that the postbiotic recipients had more anti-inflammatory metabolites, namely, salicyloyl phytophingosine, podophylloxin, securinine, baicalein, and diosmetin. Fecal metagenomics analysis revealed that the postbiotic recipients had more beneficial microbes and less pro-inflammatory bacteria. This study confirmed that postbiotics are effective in alleviating colitis in a dosedependent manner. Our findings are of interest to food scientists, clinicians, and the health food industry.

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Section: Discussionsupporting

confidence: 90%

Postbiotic Administration Ameliorates Colitis and Inflammation in Rats Possibly through Gut Microbiota Modulation

Feng,

Peng,

Zhang

et al. 2024

J. Agric. Food Chem.

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“…In this study, we observed increased DAI scores in the DSS group during the DSS administration period, which was consistent with the literature on DSS-induced colitis in mice [ 20 ] and pigs [ 24 ], confirming the successful establishment of DSS-induced enteric inflammation in broilers. However, during the period of DSS induction, there was no significant loss in the BW of broilers according to daily BW records, which is inconsistent with the results of studies on colitis in mice [ 7 , 25 ]. One potential reason for this discrepancy may be that the DSS dose used in our study induced low-grade enteric inflammation rather than acute enteric inflammation.…”

Section: Discussioncontrasting

confidence: 72%

Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium

Liu

Sui

Ya-jin

et al. 2022

Animals

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This study aimed to evaluate the effectiveness of oral gavage of dextran sodium sulfate (DSS) to establish an enteric inflammation model in broilers. Forty 1-day-old male, yellow-feathered broilers were randomly divided into 2 groups with 5 replicates of 4 birds each for a 42-day trial. The experiment design used 2 groups: (1) the control group (CT), normal broilers fed a basal diet, and (2) the DSS group, DSS-treated broilers fed a basal diet. The DSS group received 1 mL of 2.5% DSS solution once a day by oral gavage from 21 to 29 days of age. The results showed that compared with those in CT, DSS treatment significantly increased histological scores for enteritis and mucosal damage at 29 and 42 days of age (p < 0.01) and the disease activity index (DAI) from 23 to 29 days of age (p < 0.01). DSS-treated broilers showed poor growth performance at 42 days of age, including decreased body weight and average daily gain and an increased feed conversion ratio (p < 0.01). DSS also caused gross lesions and histopathological damage in the jejunum of broilers, such as obvious hemorrhagic spots, loss of villus architecture, epithelial cell disruption, inflammatory cell infiltration, and decreased villus height. These results suggest that oral gavage of DSS is an effective method for inducing mild and non-necrotic enteric inflammation in broilers.

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“…Feng et al [ 16 ] explored the ameliorating effects of pasteurized probiotic fermented milk on DSS-induced IBD in rats and found that intragastric gavage of milk prominently declined the disease activity index (DAI) scores and alleviated the colon tissue damage. The improvement was ascribed to the anti-inflammatory effect of the probiotic by decreasing TNF-α and IL-6 levels.…”

Section: Probiotics In Ibdmentioning

confidence: 99%

Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives

Roy¹,

Dhaneshwar²

2023

World J Gastroenterol

100

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Experimental evidence supports the fact that changes in the bowel microflora due to environmental or dietary factors have been investigated as implicating factors in the etiopathogenesis of inflammatory bowel disease (IBD). The amassing knowledge that the inhabited microbiome regulates the gut physiology and immune functions in IBD, has led researchers to explore the effectiveness of prebiotics, probiotics, and synbiotics in treating IBD. This therapeutic approach focuses on restoring the dynamic balance between the microflora and host defense mechanisms in the intestinal mucosa to prevent the onset and persistence of intestinal inflammation. Numerous microbial strains and carbohydrate blends, along with their combinations have been examined in experimental colitis models and clinical trials, and the results indicated that it can be an attractive therapeutic strategy for the suppression of inflammation, remission induction, and relapse prevention in IBD with minimal side effects. Several mechanisms of action of probiotics (for e.g., Lactobacillus species, and Bifidobacterium species) have been reported such as suppression of pathogen growth by releasing certain antimicrobial mediators (lactic and hydrogen peroxide, acetic acid, and bacteriocins), immunomodulation and initiation of an immune response, enhancement of barrier activity, and suppression of human T-cell proliferation. Prebiotics such as lactulose, lactosucrose, oligofructose, and inulin have been found to induce the growth of certain types of host microflora, resulting in an enriched enteric function. These non-digestible food dietary components have been reported to exert anti-inflammatory effects by inhibiting the expression of tumor necrosis factor-α-related cytokines while augmenting interleukin-10 levels. Although pro-and prebiotics has established their efficacy in healthy subjects, a better understanding of the luminal ecosystem is required to determine which specific bacterial strain or combination of probiotics and prebiotics would prove to be the ideal treatment for IBD. Clinical trials, however, have given some conflicting results, requiring the necessity to cite the more profound clinical effect of these treatments on IBD remission and prevention. The purpose of this review article is to provide the most comprehensive and updated review on the utility of prebiotics, probiotics, and synbiotics in the management of active Crohn’s disease and ulcerative colitis/pouchitis.

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Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats

Cited by 18 publications

References 60 publications

Postbiotic Administration Ameliorates Colitis and Inflammation in Rats Possibly through Gut Microbiota Modulation

Postbiotic Administration Ameliorates Colitis and Inflammation in Rats Possibly through Gut Microbiota Modulation

Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium

Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives

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