Oral administration of resveratrol or lactic acid bacterium improves lens elasticity

Nagashima, Hitoshi; Sasaki, Norihiko; Amano, Sachie; Nakamura, Shigeru; Hayano, Motoshi; Tsubota, Kazuo

doi:10.1038/s41598-021-81748-w

Cited by 7 publications

(6 citation statements)

References 53 publications

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“…Both the short-term and long-term administration of resveratrol and WB2000 mitigated the increase in lens stiffness, whereas the administration of TJ515 alone decreased the lens stiffness with long-term, but not short-term administration. 79 These results indicate that the oral supplementation of an antioxidative diet could be a potential candidate to ameliorate near vision impairment encountered during presbyopia.…”

Section: The Patient Experience Of / Journey Through Presbyopiamentioning

confidence: 89%

New insights in presbyopia: impact of correction strategies

2023

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Presbyopia occurs when the physiologically normal age-related reduction in the eyes focusing range reaches a point, when optimally corrected for distance vision, that the clarity of vision at near is insufficient to satisfy an individual’s requirements. Hence, it is more about the impact it has on an individual’s visual ability to function in their environment to maintain their lifestyle than a measured loss of focusing ability. Presbyopia has a significant impact on an individual’s quality of life and emotional state. While a range of amelioration strategies exist, they are often difficult to access in the developing world and prescribing is generally not optimal even in developed countries. This review identified the need for a standardised definition of presbyopia to be adopted. An appropriate battery of tests should be applied in evaluating presbyopic management options and the results of clinical trials should be published (even if unsuccessful) to accelerate the provision of better outcomes for presbyopes.

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Section: The Patient Experience Of / Journey Through Presbyopiamentioning

confidence: 89%

New insights in presbyopia: impact of correction strategies

2023

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“…This is in contrast to the quite active research interest in presbyopia. In addition to the miotics and lipoic acid choline esters discussed at the roundtable, there have been reports on improved lens elasticity and accommodation from anti-oxidant supplementation, resveratrol, lactic acid bacteria or periocular warming [26][27][28]. A greater awareness of emerging alternatives to current visual aids may empower those with presbyopia in their discussions with HCPs.…”

Section: Discussionmentioning

confidence: 99%

Living with presbyopia: experiences from a virtual roundtable dialogue among impacted individuals and healthcare professionals

Brujic

Kruger²,

Todd

et al. 2022

BMC Ophthalmol

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Background Presbyopia is a common progressive vision disorder characterised by an inability to focus on near objects. The emergence of newer treatment options in addition to spectacles or contact lenses highlights the importance of assessing patient/user preferences. Methods People with presbyopia and healthcare professionals (HCPs) took part in a moderated, structured discussion of specific questions on a virtual advisory-board platform. The objective was to better understand unmet needs and the experience of living with the condition. Closed and open questions were included. Results Nine individuals (age 40 to 70 years) with presbyopia participated, from Australia, China, France, Italy, Ireland, Japan and the US. One ophthalmologist and one optometrist represented the perspective of HCPs. Over two weeks, 621 posts were entered on the platform. There was widespread agreement that the often stated association between age and presbyopia was unfortunate. Some participants had developed presbyopia at 30–45 years of age. What is more, the association with age was seen as implying a natural process, reducing the incentive to treat. Instead there was a call for an action-oriented view of presbyopia as a condition which may be effectively treated in the future. All participants experienced dealing with presbyopia as burdensome, affecting quality of life to varying degrees. When considering new treatments, convenience was the most important factor. The option to administer drops when needed was considered favourable, but short-acting treatments may not reduce inconvenience compared with spectacles. Participants viewed a therapy that targets the underlying cause of the condition favourably compared with symptomatic treatment. Side effects would severely reduce the appeal of drops. For clinical trials in presbyopia, patient-reported outcomes should be mandatory and need adequately to capture quality of life. Studies in presbyopia must be designed to minimise the inconvenience to participants in order to counter the risk of high drop-out rates. Conclusions The interactive format provided insights into living with presbyopia, particularly the negative impact on quality of life, subjects’ openness to new therapies, and the need to move away from considering the condition an unavoidable and intractable consequence of ageing.

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“…32) In a previous study, L. pentosus TJ515 produced more anti-inflammatory cytokines such as interleukin-10 (IL-10) and interferon-γ (IFN-γ) than the control stain L. pentosus JCM1558 in mesenteric lymph node cells. 32) Given that it has been reported that dietary supplementation with L. pentosus TJ515 and resveratrol could manage the progression of near vision impairment, 33) L. pentosus TJ515 taken orally could exert an action in the eye. Thus, L. pentosus TJ515 is expected to prevent retinal inflammatory diseases by regulating systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Intake of <i>Lactobacillus Pentosus TJ515</i> Prevents the Formation of Retinal Edema in Retinal Vein Occlusion Model Mice

et al. 2023

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Macular edema is a sight-threatening symptom in patients with retinal vein occlusion (RVO) and diabetic retinopathy. It is treated by the intravitreal injection of anti-vascular endothelial growth factor agents, but this has a physical burden on patients. Thus, it is important to develop a treatment that can be administered orally. The probiotic Lactobacillus pentosus TJ515 can reduce inflammation by regulating host immunity via its induction of interleukin-10 (IL-10). However, its action on inflammatory diseases of the retina remains unclear. This study aimed to investigate the preventive effects of L. pentosus TJ515 intake on retinal edema using RVO model mice. Occlusion of the retinal vein led to an increase in the thickness of all retinal layers and the inner nuclear layer. Intake of L. pentosus TJ515 for three weeks suppressed the formation of retinal edema versus vehicle and the control strain (L. pentosus JCM1558). The expression of MCP-1 and MCP-3 was increased in RVO model mice but suppressed by the intake of L. pentosus TJ515. F4/80-positive cells (i.e., activated macrophages) were increased in the retinas of RVO model mice but decreased by the intake of L. pentosus TJ515. Therefore, L. pentosus TJ515 suppressed macrophage migration in the retinas. Treatment of mouse bone marrow-derived macrophages (BMDM) with plasma from mice that had ingested L. pentosus TJ515 decreased the mRNA expression of IL-6 and increased the mRNA expression of IL-10. Thus, oral intake of L. pentosus TJ515 can prevent retinal edema through its anti-inflammatory effects on macrophages and inhibiting effects on macrophage migration.

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Oral administration of resveratrol or lactic acid bacterium improves lens elasticity

Cited by 7 publications

References 53 publications

New insights in presbyopia: impact of correction strategies

New insights in presbyopia: impact of correction strategies

Living with presbyopia: experiences from a virtual roundtable dialogue among impacted individuals and healthcare professionals

Intake of <i>Lactobacillus Pentosus TJ515</i> Prevents the Formation of Retinal Edema in Retinal Vein Occlusion Model Mice

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