Oral administration of sea cucumber (Stichopus japonicus) protein exerts wound healing effectsviathe PI3K/AKT/mTOR signaling pathway

Abstract

The present study aimed to investigate the oral administration of sea cucumber protein (SCP) effect on wound healing. SCP was isolated and purified from the body wall of Stichopus japonicus....

Exosomes derived from tendon stem/progenitor cells enhance tendon-bone interface healing after rotator cuff repair in a rat model

“…The AKT/mTOR signaling pathway participates in cellular proliferation, differentiation, apoptosis, and metastasis, giving it a crucial role in various diseases [ [52] , [53] , [54] ]. Reports suggest that the AKT/mTOR signaling pathway may serve as a crucial node in tendon differentiation [ 55 ].…”

Chemical substances and their activities in sea cucumber Apostichopus japonicus: A review

“…They promote wound repair by activating the ERK/protein kinase B (ERK/AKT) and phosphoinositide 3-kinase/protein kinase B/ mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway, upregulating proinflammatory cytokines IL-1β, IL-6, and TNF-α in the wound stage, downregulating IL-8 in the healing stage, and upregulating the anti-inflammatory cytokine IL-10. [80,158] In summary, A. japonicus proteins, polysaccharides, and hydrolysates exert biological activity on the skin by inhibiting Tyr, promoting collagen synthesis, improving cell viability, and regulating inflammatory factors. A. japonicus extracts can be used as a new type of antimelanin, antiaging, antioxidation, antiwrinkle, wound-healing cosmetics, biological dressings, and biological products.…”

“…They promote wound repair by activating the ERK/protein kinase B (ERK/AKT) and phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway, upregulating proinflammatory cytokines IL‐1β, IL‐6, and TNF‐α in the wound stage, downregulating IL‐8 in the healing stage, and upregulating the anti‐inflammatory cytokine IL‐10. [ 80,158 ]…”