Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment

Ando, Hidenori; Ikeda, Ai; Tagami, Maho; Matsuo, Nana Cristina Amorim; Shimizu, Taro; Ishima, Yu; Eshima, Kiyoshi; Ishida, Tatsuhiro

doi:10.1016/j.jconrel.2022.08.031

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…The adsorption of I – and F – , on FMBO (eqs and ) was achieved by the formation of Fe–X (X = I and F) bonds, whereas that of SO 4 2– , , NO 3 – , and HCO 3 – was attributed to the formation of Fe–O bonds. It was noted that the released H + from the as-prepared acidic FMBO tended to react with HCO 3 – (eq ). Simultaneously, the Mn(IV) within FMBO may moderately oxidize I – to HOI/I 2 or overoxidize I – to IO 3 – (eqs and ), and the reduction of Mn(IV) to Mn(III)/Mn(II) in solution occurs (eqs and ) .…”

Section: Results and Discussionmentioning

confidence: 99%

Synchronous Removal of Fluoride and Iodide on Fe–Mn Binary Oxides Interface: Competitive Adsorption Behaviors and Mechanism

Wang,

Liang,

Zhang

et al. 2024

ACS EST Eng.

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The coexistence of high-concentration iodide (I − ) and fluoride (F − ) in high-iodine groundwater increases the occurrence of endemic diseases such as iodine-induced disorders and fluorosis, and their simultaneous removal has rarely been investigated. In this study, we developed cost-effective Fe/Mn binary oxides (FMBOs) with different Fe/Mn molar ratios (R Fe:Mn ) and investigated their performance and selective adsorption mechanisms for the synchronous removal of I − and F − . By optimizing the R Fe:Mn ratios, an FMBO with R Fe:Mn = 0.5:1 was developed to achieve synchronous removal of I − and F − with efficiencies of 67.7 and 80.7%, respectively, when the initial concentrations of I − and F − were 200 μg/L and 1.5 mg/L, and the FMBO dosage was 1.0 g/L. As the pH increases, the removal efficiency of I − and F − by FMBO decreases. According to the results of X-ray photoelectron spectroscopy (XPS), high-performance liquid chromatography−inductively coupled plasma mass spectrometry (HPLC-ICP/MS), and X-ray absorption spectroscopy results (XAS), FMBO is mainly composed of Fe(III), Mn(IV), and Mn(III). Mn oxide is mainly responsible for the heterogeneous oxidation of I − , whereas Fe oxide dominates in the adsorption of I − and F − . Based on density functional theory (DFT) calculations, the adsorption of SO 4 2− , NO 3 − , and HCO 3 − was achieved via the formation of Fe−O bonds; moreover, the adsorption of I − and F − was attributed to the formation of Fe−I/F bonds. This study provides insight into the site-specific mechanism involved in I − and F − adsorption onto low-cost FMBO in realistic high-iodide groundwaters with complex coexisting anions.

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Section: Results and Discussionmentioning

confidence: 99%

Synchronous Removal of Fluoride and Iodide on Fe–Mn Binary Oxides Interface: Competitive Adsorption Behaviors and Mechanism

Wang,

Liang,

Zhang

et al. 2024

ACS EST Eng.

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“…The design of pH-responsive nanomedicine delivery carriers plays a crucial role in harnessing the pH disparity between tumor and normal tissues. These carriers are responsible for maintaining drug stability under physiological conditions while facilitating targeted aggregation and release at the tumor site [ 34 , 35 ]. Therefore, we examined the release of ZIF-8@ICG@Tax under different pH and irradiation conditions.…”

Section: Resultsmentioning

confidence: 99%

Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer

Lu,

Pan,

Zheng

et al. 2024

J Mater Sci: Mater Med

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This study leverages nanotechnology by encapsulating indocyanine green (ICG) and paclitaxel (Tax) using zeolitic imidazolate frameworks-8 (ZIF-8) as a scaffold. This study aims to investigate the chemo-photothermal therapeutic potential of ZIF-8@ICG@Tax nanoparticles (NPs) in the treatment of non-small cell lung cancer (NSCLC). An “all-in-one” theranostic ZIF-8@ICG@Tax NPs was conducted by self-assembly based on electrostatic interaction. First, the photothermal effect, stability, pH responsiveness, drug release, and blood compatibility of ZIF-8@ICG@Tax were evaluated through in vitro testing. Furthermore, the hepatic and renal toxicity of ZIF-8@ICG@Tax were assessed through in vivo testing. Additionally, the anticancer effects of these nanoparticles were investigated both in vitro and in vivo. Uniform and stable chemo-photothermal ZIF-8@ICG@Tax NPs had been successfully synthesized and had outstanding drug releasing capacities. Moreover, ZIF-8@ICG@Tax NPs showed remarkable responsiveness dependent both on pH in the tumor microenvironment and NIR irradiation, allowing for targeted drug delivery and controlled drug release. NIR irradiation can enhance the tumor cell response to ZIF-8@ICG@Tax uptake, thereby promoting the anti-tumor growth in vitro and in vivo. ZIF-8@ICG@Tax and NIR irradiation have demonstrated remarkable synergistic anti-tumor growth properties compared to their individual components. This novel theranostic chemo-photothermal NPs hold great potential as a viable treatment option for NSCLC. Graphical Abstract

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“…Ando et al [ 111 ] analyzed per oral NaHCO 3 -loaded liposomes with intravenous Doxil in colon 26 tumor-bearing mice. Both intravenous and orally administered NaHCO 3 showed clear DOX accumulation in the tumor tissue as well as a 9- and 2-fold decrease in tumor size compared with free DOX and Doxil alone, respectively.…”

Section: Obstacles In and Strategies For Formulating Dox To Enhance O...mentioning

confidence: 99%

“…A previously reported diffusion model with MDA-MB-231 showed that orally administered bicarbonate had no influence on acidic tumor environment [ 112 ]. However, Ando et al suggested that NaHCO 3 is a promising candidate for combination with DOX as long as it is released at a local tumor site [ 111 ] ( Table 3 ).…”

Section: Obstacles In and Strategies For Formulating Dox To Enhance O...mentioning

confidence: 99%

Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting

2023

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Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via multiple intracellular interactions, generating reactive oxygen species and DNA-adducted configurations that induce apoptosis, topoisomerase II inhibition, and histone eviction. Despite its wide therapeutic efficacy in solid tumors, DOX often induces drug resistance and cardiotoxicity. It shows limited intestinal absorption because of low paracellular permeability and P-glycoprotein (P-gp)-mediated efflux. We reviewed various parenteral DOX formulations, such as liposomes, polymeric micelles, polymeric nanoparticles, and polymer-drug conjugates, under clinical use or trials to increase its therapeutic efficacy. To improve the bioavailability of DOX in intravenous and oral cancer treatment, studies have proposed a pH- or redox-sensitive and receptor-targeted system for overcoming DOX resistance and increasing therapeutic efficacy without causing DOX-induced toxicity. Multifunctional formulations of DOX with mucoadhesiveness and increased intestinal permeability through tight-junction modulation and P-gp inhibition have also been used as orally bioavailable DOX in the preclinical stage. The increasing trends of developing oral formulations from intravenous formulations, the application of mucoadhesive technology, permeation-enhancing technology, and pharmacokinetic modulation with functional excipients might facilitate the further development of oral DOX.

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Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment

Cited by 10 publications

References 26 publications

Synchronous Removal of Fluoride and Iodide on Fe–Mn Binary Oxides Interface: Competitive Adsorption Behaviors and Mechanism

Synchronous Removal of Fluoride and Iodide on Fe–Mn Binary Oxides Interface: Competitive Adsorption Behaviors and Mechanism

Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer

Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting

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