Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes

Chu, Yenju; Qin, Chaolong; Feng, Wanshan; Sheriston, Charles; Khor, Yu Jane; Medrano-Padial, Concepción; Watson, Birgit; Chan, Teddy; Ling, Binhua; Stocks, Michael J.; Fischer, Peter M.; Gershkovich, Pavel

doi:10.1016/j.ijpharm.2021.120621

Cited by 10 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drugs delivered to the colon may also enter systemic circulation via the mesenteric lymph nodes (MLNs), especially if delivering lipophilic drugs in highly lipidic formulations [82,83]. The network of lymph nodes around the colon is positioned similarly to the vascular network, and functions to drain interstitial fluid, chyle, antigens, and plasma cells/proteins from colonic tissue [84].…”

Section: Vascular and Lymphatic Networkmentioning

confidence: 99%

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

McCoubrey

Favaron

Awad

et al. 2023

Journal of Controlled Release

View full text Add to dashboard Cite

Section: Vascular and Lymphatic Networkmentioning

confidence: 99%

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

McCoubrey

Favaron

Awad

et al. 2023

Journal of Controlled Release

View full text Add to dashboard Cite

“…As mentioned previously, current antiretroviral therapy (ART) can achieve long-term suppression of plasma viral load to levels less than 20 copies per millimeter of plasma, especially when they are initiated early in PLWH; however, optimal ARV drug penetration in lymphoid tissues, such as lymph nodes, spleen, and gut-associated lymphoid tissue (GALT), is under debate in these individuals [ 110 , 111 , 112 ]. Data show that, despite ART, these tissues can become pharmacological sanctuaries that result in incomplete suppression of viral replication.…”

Section: Clinical Parameters In Plwh May Impact the Efficacy Of Autop...mentioning

confidence: 99%

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

Ghahari,

Telittchenko,

Loucif

et al. 2023

IJMS

View full text Add to dashboard Cite

Like other chronic viral infections, HIV-1 persistence inhibits the development of antigen-specific memory T-cells, resulting in the exhaustion of the immune response and chronic inflammation. Autophagy is a major lysosome-dependent mechanism of intracellular large-target degradation such as lipid and protein aggregates, damaged organelles, and intracellular pathogens. Although it is known that autophagy may target HIV-1 for elimination, knowledge of its function as a metabolic contributor in such viral infection is only in its infancy. Recent data show that elite controllers (EC), who are HIV-1-infected subjects with natural and long-term antigen (Ag)-specific T-cell protection against the virus, are characterized by distinct metabolic autophagy-dependent features in their T-cells compared to other people living with HIV-1 (PLWH). Despite durable viral control with antiretroviral therapy (ART), HIV-1-specific immune dysfunction does not normalize in non-controller PLWH. Therefore, the hypothesis of inducing autophagy to strengthen their Ag-specific T-cell immunity against HIV-1 starts to be an enticing concept. The aim of this review is to critically analyze promises and potential limitations of pharmacological and dietary interventions to activate autophagy in an attempt to rescue Ag-specific T-cell protection among PLWH.

show abstract

“…Short‐ and medium‐chain fatty acids are often transported directly through enterocytes to the portal vein and enter the systemic circulation (Tanaka et al., 2021). Long‐chain fatty acids are usually transported into the Golgi apparatus to form chylomicrons combining with proteins and then enter the systemic circulation via the lymph capillary (Chu et al., 2021; T. Wang & Luo, 2019). Wang et al.…”

Section: Absorption Mechanismmentioning

confidence: 99%

Recent advances in bioactive nanocrystal‐stabilized Pickering emulsions: Fabrication, characterization, and biological assessment

Yang

Feng

Yao

et al. 2022

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Numerous literatures have shown the advantages of Pickering emulsion (PE) for the delivery of bioactive ingredients in the fields of food, medicine, and cosmetics, among others. On this basis, the multi‐loading mode of bioactives (internal phase encapsulation and/or loading at the interface) in small molecular bioactives nanocrystal‐stabilized PE (BNC‐PE) enables them higher loading efficiencies, controlled release, and synergistic or superimposed effects. Therefore, BNC‐PE offers an efficacious delivery system. In this review, we briefly summarize BNC‐PE fabrication and characterization, with a focus on the processes of possible evolution and absorption of differentially applied BNC‐PE when interacting with the body. In addition, methods of monitoring changes and absorption of BNC‐PE in vivo, from the nanomaterial perspective, are also introduced. The purpose of this review is to provide an accessible and comprehensive methodology for the characterization and evaluation of BNC‐PE after formulation and preparation, especially in relation to biological assessment and detailed mechanisms throughout the absorption process of BNC‐PE in vivo.

show abstract

Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes

Cited by 10 publications

References 45 publications

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

Recent advances in bioactive nanocrystal‐stabilized Pickering emulsions: Fabrication, characterization, and biological assessment

Contact Info

Product

Resources

About