Oral Administration of Vitamin C Prevents Alveolar Bone Resorption Induced by High Dietary Cholesterol in Rats

Sanbe, Toshihiro; Tomofuji, Takaaki; Ekuni, Daisuke; Azuma, Tetsuji; Tamaki, Naofumi; Yamamoto, Tatsuo

doi:10.1902/jop.2007.070181

Cited by 70 publications

(69 citation statements)

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“…13,34 This evidence indicates that oxidative stress plays a crucial role in osteoclast differentiation. In this study, the obese rats with exercise training exhibited a lower number of TRAP-positive osteoclasts than those without exercise training at 8 weeks.…”

Section: Discussionmentioning

confidence: 98%

Effects of exercise training on gingival oxidative stress in obese rats

Azuma

Tomofuji

Endo

et al. 2011

Archives of Oral Biology

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Objective: The purpose of the present study was to investigate the effects of exercise training on serum reactive oxygen species (ROS) level and gingival oxidative stress in obese rats fed a high-fat diet.Design: Rats were divided into three groups (n=14/group): one control group (fed a regular diet) and two experimental groups (fed a high-fat diet with and without exercise training [treadmill: 5 days/week]). The rats were sacrificed at 4 or 8 weeks. The level of serum reactive oxidative metabolites (ROM) was measured as an indicator of circulating ROS. The level of 8-hydroxydeoxyguanosine (8-OHdG) and reduced-form glutathione (GSH)/oxidized-form glutathione (GSSG) ratio were determined to evaluate gingival oxidative stress. Results:The obese rats fed a high-fat diet without exercise training showed higher serum ROM levels [Carratelli Units (CARR U)] (mean ±SD; 413 ±64) than the control (333 ±12) at 4 weeks (p= 0.023). Such a condition resulted in higher 8-OHdG levels (ng/mg mtDNA) (0.97 ±0.18) (p< 0.05) and a lower GSH/GSSG ratio (17.0 ±3.1) (p< 0.05) in gingival tissues, compared to the control (0.55 ±0.13 for 8-OHdG and 23.6 ±5.8 for GSH/GSSG ratio) at 8 weeks. In addition, the obese rats fed a high-fat diet with exercise training showed lower serum ROM (623 ±103) (p< 0.001) and gingival 4 8-OHdG levels (0.69 ±0.17) (p= 0.012) than those without exercise training (1105 ±95 for ROM and 0.55 ±0.13 for 8-OHdG) at 8 weeks. Conclusions:Obesity prevention by exercise training may effectively suppress gingival oxidative stress by decreasing serum ROS in rats.

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Section: Discussionmentioning

confidence: 98%

Effects of exercise training on gingival oxidative stress in obese rats

Azuma

Tomofuji

Endo

et al. 2011

Archives of Oral Biology

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“…Vitamin C can alter bone resorption by osteoclasts [12] and is required for osteoblast differentiation [35]. Several experimental studies have shown favorable roles of vitamin C in skeletogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C is a well-known antioxidant and acts as a scavenger of superoxide anion and hydrogen peroxide [8,9]. Administration of vitamin C in vivo prevented bone loss with decreased reactive oxygen species [10][11][12]. Some studies of humans also showed that high plasma levels or dietary intake of antioxidants is associated with increased bone mineral density [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status

Kim

Lim

et al. 2015

Osteoporos Int

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“…Regarding experimental studies, animal research conducted in rats (Rattus norvergicus) fed on vitamin C-supplemented or -deficient diets by incorporated it to drinking water have shown positive effects for this nutrient 52,53 . In one, periodontitis was experimentally induced by ligatures placement around molars for 4 weeks and dietary treatment (1g/l vitamin C) started after removing ligatures.…”

Section: Ascorbic Acidmentioning

confidence: 99%

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

et al. 2015

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LICENSE 3.0 UNPORTED. RESUMENObjetivos. Dada la relación existente entre periodontitis crónica y altos niveles de estrés oxidativo, esta revisión pretende clarificar qué papel puede desempeñar la ingesta de los diferentes antioxidantes de la dieta en el mantenimiento de un periodonto saludable y en la reducción del riesgo de padecer periodontitis crónica, así como el posible uso de terapias dietéticas basadas en estos para el tratamiento de dicha enfermedad.Métodos. Se utilizó la base de datos de la National Library of Medicine, Washington, DC (MEDLINE: PubMed) y todos los estudios en animales y humanos tratando el tema de interés en escritos Inglés disponibles online desde la creación de la base de datos hasta Mayo de 2015 fueron recopilados.Resultados. Los antioxidantes analizados a este respecto incluyen a la vitamina C, la vitamina A, algunos carotenoides y polifenoles, y el coenzima Q; así como los minerales, hierro, cobre y zinc que forman parte de enzimas antioxidantes. Aun así hay una escasez generalizada de estudios con pocos estudios en humanos, la mayoría de tipo observacional. Entre los diferentes antioxidantes, la vitamina E y los polifenoles parecen ser los que más evidencias a favor de su efecto beneficioso suman, pero en general los estudios son insuficientes para descartar o establecer qué antioxidantes son útiles y cuáles no.Conclusiones. En general, los datos presentados indicarían que los antioxidantes de la dieta resultan beneficiosos para la salud periodontal, al menos bajo ciertas circunstancias. Sin embargo se necesitan más estudios para establecer la relación entre la periodontitis crónica y cada antioxidante concreto así como para diseñar intervenciones dietéticas útiles en la gestión de esta enfermedad. Methods. The database of the National Library of Medicine, Washington, DC (MEDLINE PubMed) was used and all the studies in animals and humans are on the subject of interest in English writing online available from inception of the database until May 2015 were collected.Results. Antioxidants analyzed in this regard include vitamin C, vitamin A, carotenoids and some polyphenols, and coenzyme Q; as well as minerals iron, copper and zinc that are constituents of antioxidant enzymes. Still, there is a paucity of studies with few human studies, mostly observational. Among the various antioxidants, vitamin E and polyphenols seem to have more evidence for its beneficial effect, but Artículo de revisión Review Article Correspondencia CorrespondenceJosé Luis Quiles Morales, Centro de Investigación Biomédica (CIBM), Lab. 250. Universidad de Granada, Avda. del Conocimiento s.n., 18100 Armilla, Granada, España. E-Mail: jlquiles@ugr. es; Tel.: +34958241000 (ext. 20316). Financiación FundingsTrabajo realizado sin financiación. Conflicto de interés Competing interest No hay conflicto de intereses Agradecimientos AcknowledgementsLos autores agradecen a la Junta de Andalucía y a la Universidad de Granada por el continuo soporte al grupo de investigación. Alfonso Varela López es contratado FPU del Ministe...

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Oral Administration of Vitamin C Prevents Alveolar Bone Resorption Induced by High Dietary Cholesterol in Rats

Abstract: In the rat model, vitamin C suppressed alveolar bone resorption, induced by high dietary cholesterol, by decreasing the oxidative damage of periodontal tissue.

Cited by 70 publications

References 31 publications

Effects of exercise training on gingival oxidative stress in obese rats

Effects of exercise training on gingival oxidative stress in obese rats

Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

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