Oral Allergy Syndrome in Birch Pollen-Sensitized Patients from a Korean University Hospital

Kim, Jung Hyun; Kim, Sae Hoon; Park, Heung-Woo; Cho, Sang Heon; Chang, Yoon-Seok

doi:10.3346/jkms.2018.33.e218

Cited by 27 publications

(31 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar sensitization rates were observed for Bet v 1 homologues like Mal d 1 (apple) and Cor a 1 (hazelnut), mostly due to cross-reactivity occurring between structurally similar PR-10 proteins [35,36]. This results in clinical manifestations described as the oral allergy syndrome (OAS), a very common allergic disorder affecting more than 50% of birch pollen allergic patients [37]. Bet v 1.0101 (formerly designated Bet v 1a) represents the most abundant isoform of Bet v 1 comprising 50 to 70% of the allergen in pollen [4,5].…”

Section: Ligand Binding Of Bet Vmentioning

confidence: 59%

Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family

Aglas

Soh

Kraiem

et al. 2020

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Purpose of Review Pathogenesis-related class 10 (PR-10) proteins are highly conserved plant proteins, which are induced in response to abiotic and biotic stress factors. To date, no unique biological function could be assigned to them. Rather a more general role of PR-10 in plant development and defense mechanisms has been proposed. In addition, some PR-10 proteins act as allergens by triggering allergic symptoms in sensitized individuals. Regardless of the diversity of reported activities, all PR-10 proteins share a common fold characterized by a solvent-accessible hydrophobic cavity, which serves as a binding site for a myriad of small-molecule ligands, mostly phytohormones and flavonoids. Recent Findings Most of available data relate to the ligand binding activity of allergenic PR-10, particularly for those belonging to Bet v 1 family of allergens. Bet v 1 and its homologues were shown to bind flavonoids with high affinity, but the specificity appears to differ between homologues from different species. The flavonoid Q3O-(Glc)-Gal was shown to specifically bind to hazelnut Cor a 1 but not to Bet v 1. Similarly, Q3OS bound only to the major isoform Bet v 1.0101 and not to other closely related isoforms. In contrast, Bet v 1 and hazelnut Cor a 1 showed very similar binding behavior towards other flavonoids such as quercetin, genistein, apigenin, daidzein, and resveratrol. Summary Recent research findings highlighted the importance of more precise knowledge of ligand binding for understanding the functional diversification of PR-10 proteins.

show abstract

Section: Ligand Binding Of Bet Vmentioning

confidence: 59%

Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family

Aglas

Soh

Kraiem

et al. 2020

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

show abstract

“…Although the importance of PFAS is increasing and triggering foods differ from geographic regions and dietary habits, there are only a few studies on PFAS in Korea 1213. The first nationwide study of PFAS in Korea recently reported that the prevalence of PFAS is 41.7% in Korean patients with pollinosis and that 8.9% of patients with PFAS manifest with anaphylaxis, which is a substantial proportion among patients with PFAS 14…”

Section: Introductionmentioning

confidence: 99%

Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen-Food Allergy Syndrome

et al. 2019

View full text Add to dashboard Cite

PurposeMany studies have reported that pollen-food allergy syndrome (PFAS) can cause anaphylaxis. No comprehensive investigations into anaphylaxis in PFAS have been conducted, however. In this study, we investigated the clinical manifestations and risk factors for anaphylaxis in PFAS in Korean patients with pollinosis.Materials and MethodsData were obtained from a nationwide cross-sectional study that previously reported on PFAS in Korean patients with pollinosis. Data from 273 patients with PFAS were collected, including demographics, list of culprit fruits and vegetables, and clinical manifestations of food allergy. We analyzed 27 anaphylaxis patients and compared them with patients with PFAS with oropharyngeal symptoms only (n=130).ResultsThe most common cause of anaphylaxis in PFAS was peanut (33.3%), apple (22.2%), walnut (22.2%), pine nut (18.5%), peach (14.8%), and ginseng (14.8%). Anaphylaxis was significantly associated with the strength of sensitization to alder, hazel, willow, poplar, timothy, and ragweed (p<0.05, respectively). Multivariable analysis revealed that the presence of atopic dermatitis [odds ratio (OR), 3.58; 95% confidence interval (CI), 1.25–10.23; p=0.017]; sensitization to hazel (OR, 5.27; 95% CI, 1.79–15.53; p=0.003), timothy (OR, 11.8; 95% CI, 2.70–51.64; p=0.001), or ragweed (OR, 3.18; 95% CI, 1.03–9.87; p=0.045); and the number of culprit foods (OR, 1.25; 95% CI, 1.15–1.37; p<0.001) were related to the development of anaphylaxis in PFAS.ConclusionThe most common culprit foods causing anaphylaxis in PFAS were peanut and apple. The presence of atopic dermatitis; sensitization to hazel, timothy, or ragweed; and a greater number of culprit foods were risk factors for anaphylaxis in PFAS.

show abstract

“…One-third of FA patients had accompanying PFAS, which is believed to have been affected by the high coexistence of AR in the FA. Kim et al 14. previously reported that 96.2% cases of FA among birch pollinosis patients were PFAS.…”

Section: Discussionmentioning

confidence: 96%

“…As there are few previous studies regarding Korean adult FA epidemiology, this study is important 11121314. Moreover, as commonly consumed foods and environmental factors are rapidly changing, previous epidemiologic studies do not necessarily represent the current status 121.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study

Lee

Kim

Park

et al. 2019

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

Purpose To investigate the causative allergens and clinical characteristics of Korean adult patients with food allergy (FA). Methods This retrospective, cross-sectional single-institutional study enrolled Korean adult patients (n = 812) suspected of having FA. For diagnosis, causality assessment history taking, ImmunoCAP specific immunoglobulin E measurement and/or skin prick test were performed. Results Among 812 patients, 415 were diagnosed as having FA. The most common causative allergen was fruit, with a diagnosis of pollen food allergy syndrome (PFAS: 155, 37.3%), followed by crustaceans (111, 26.7%), wheat (63, 15.1%), fruits in patients without PFAS(43, 10.3%), buckwheat (31, 7.4%), peanut (31, 7.4%), walnut (25, 6.0%), red meat due to reaction to galactose-α-1,3-galactose (α-Gal) (8, 1.9%), and silkworm pupa (13, 3.1%). Allergy to egg, milk, fish, or shellfish was rare in Korean adults. One-third of patients with FA exhibited multiple FAs (238/415, 57.3%); the average number of causative allergens was 2.39. About 129 patients (31.0%) were diagnosed as having anaphylaxis; in these patients, wheat was the most frequent causative food. Twenty patients were further diagnosed with food-dependent exercise-induced anaphylaxis (FDEIA); all were due to wheat. In particular, crustaceans, wheat, PFAS, buckwheat, and red meat (α-Gal) were also frequent causes of anaphylaxis. Conclusions Wheat, fruits with or without PFAS, and crustaceans are important and frequent causative allergens in Korean adult FA; these allergens differ from those found in childhood FA. It is notable that non-classic allergies, such as PFAS, FDEIA, and α-Gal allergy, are the important causes of anaphylaxis in Korean adult FA.

show abstract

Oral Allergy Syndrome in Birch Pollen-Sensitized Patients from a Korean University Hospital

Cited by 27 publications

References 26 publications

Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family

Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family

Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen-Food Allergy Syndrome

Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study

Contact Info

Product

Resources

About