Oral and craniofacial research in the Generation R study: an executive summary

van Meijeren-van Lunteren, Agatha W.; Liu, Xianjing; Veenman, Francien C. H.; Grgic, Olja; Dhamo, Brunilda; van der Tas, Justin T.; Prijatelj, Vid; Roshchupkin, Gennady V.; Rivadeneira, Fernando; Wolvius, Eppo B.; Kragt, Lea

doi:10.1007/s00784-023-05076-1

Cited by 4 publications

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Postnatal Growth Trajectories and Risk of Obstructive Sleep Apnea in Middle Age: A Cohort Study

Suri,

Bhargava,

Akshara

et al. 2024

Pediatric Pulmonology

View full text Add to dashboard Cite

Study ObjectivesRapid growth in childhood predisposes to obesity and cardiometabolic diseases in adulthood. While obstructive sleep apnea (OSA) is bidirectionally linked to obesity, its developmental origins are sparsely studied. We examined associations between postnatal growth and the risk of OSA in adulthood.MethodsWe included adults whose childhood anthropometric data was collected in the New Delhi Birth Cohort study. The risk of OSA was defined by the Berlin Questionnaire (BQ) with and without the obesity criterion. Using logistic regression, we studied associations of OSA risk with conditional growth parameters, which are statistically independent measures of gain in height, weight, and body mass index (BMI), during infancy (0–2 years), early childhood (2–5 years), and late childhood (5–11 years).ResultsAmong 521 subjects (58.9% males) with a mean (SD) age of 40.9 (1.7) years, 30.9% had a high risk of OSA. On multivariate analysis, a high risk of OSA was associated with a higher conditional BMI in infancy (odds ratio: 1.25; 95% confidence interval: 1.00–1.57; p = 0.048) and early childhood (1.35; 1.07–1.69; p = 0.011). Higher risk of OSA was associated with greater conditional weight in early childhood (1.34; 1.06–1.68; p = 0.013). Using the modified BQ definition without obesity, adult risk of OSA was significantly associated with a higher adult BMI instead of childhood conditional BMIs.ConclusionsGreater gain in conditional BMI or weight in early childhood is associated with a high risk of OSA in middle age, which is mediated by a higher attained adult BMI.

show abstract

Postnatal Growth Trajectories and Risk of Obstructive Sleep Apnea in Middle Age: A Cohort Study

Suri,

Bhargava,

Akshara

et al. 2024

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

Poverty Dynamics and Caries Status in Young Adolescents

Carbajal Rodriguez,

van Meijeren‐van Lunteren,

Wolvius

et al. 2024

Comm Dent Oral Epid

View full text Add to dashboard Cite

ObjectivesTo investigate whether timing, accumulation and trajectories of poverty are associated with dental caries in young adolescents.MethodsThe study was conducted within the Generation R Study, which is an ongoing population‐based prospective cohort study conducted in Rotterdam, the Netherlands. This study included 2653 children. Information about household income and number of children and adults living in a household at six time points from pregnancy to 13 years old was retrieved from parental questionnaires to construct the poverty variable. Dental caries was assessed with the decayed, missing and filled teeth index through intraoral photographs at the age of 13 years. Sociodemographic and oral health‐related characteristics were included as possible confounders. The association between poverty and dental caries was analysed on the basis of the three lifecourse theories, that is, critical period, cumulative risk and social mobility model. For the latter, we used latent class growth analysis (LCGA) to identify poverty trajectories over time. Next, the associations were studied with Hurdle Negative Binomial Models.ResultsPoverty at birth and intermittent poverty up to the age of 13 were significantly associated with dental caries at 13 years of age (OR 1.41, 95% CI 1.01–1.99; OR 1.36, 95% CI 1.01–1.83 respectively) and with an increased mean number of decayed teeth by 34% (95% CI 1.02–1.76; 95% CI 1.05–1.71, respectively). LCGA showed four trajectories for the probabilities of poverty. All trajectories were significantly associated with dental caries at 13 years of age, with the ‘downward mobility’ trajectory showing the strongest association with dental caries (OR 1.55, 95% CI 1.05–2.29) and an increasing mean number of decayed teeth by 58% (95% CI 1.18–2.12) than the ‘stable absent’ trajectory.ConclusionPoverty at birth, intermittent poverty and downward poverty trajectory were associated with higher odds and higher mean number of decayed teeth at 13 years of age. The three lifecourse models influenced dental caries status during adolescence, hence strategies and policies targeted to improve socioeconomic conditions on deprived children should be implemented.

show abstract

Characterizing the oral microbiota of adolescents: results from the Generation R Study

Veenman,

Arredondo,

Medina-Gomez

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective The objective of this study was to investigate the microbial signature of the oral cavity in caries-free adolescents without orthodontic treatment from the general population. We also aimed to identify lifestyle factors shaping oral microbiota composition and assess the impact of technical covariates related to sample collection and analysis. Methods For the cross-sectional analysis, 750 Dutch adolescents without caries or orthodontic treatment (16.1%) were selected from all participants from the Generation R Study with oral microbiota profiling (n = 4,646). Oral microbiota data was obtained from supragingival biofilm swabs using 16S rRNA sequencing (V3-V4 region), and analyzed at four levels; core microbiota, alpha diversity, beta diversity and differential abundance. Results Participants (13.6 ± 0.29 years, 56% male) shared a large core microbiota consisting of 23 different genera, with the five most abundant and prevalent—Streptococcus, Rothia, Haemophilus, Gemella, and Neisseria—being well-known early colonizers of the dental biofilm. Among participant characteristics, tooth brushing frequency emerged as the strongest determinant of microbiota composition. Compared to participants who brushed twice or more a day, those who brushed once or less, exhibited higher bacterial richness (Chao1; β:15.04, 95% CI:1.78;28.31) and higher Porphyromonas abundance (LFC:0.63, SD:0.16, q-value:0.002). The sampling time, identified as the most impactful technical covariate, showed a negative association with bacterial richness (early-morning vs late-afternoon: Chao1; β:-57.04, 95% CI:-77.44;-36.64). Conclusion This study revealed a high similarity in oral microbiota of adolescents from the general population at the genus level, while highlighting the influence of tooth brushing frequency, sex, and sugar consumption on bacterial composition. Clinical relevance The findings provide a valuable reference for future studies exploring the link between adolescents' oral microbiota and both oral and systemic health.

show abstract

Oral and craniofacial research in the Generation R study: an executive summary

Cited by 4 publications

References 71 publications

Postnatal Growth Trajectories and Risk of Obstructive Sleep Apnea in Middle Age: A Cohort Study

Postnatal Growth Trajectories and Risk of Obstructive Sleep Apnea in Middle Age: A Cohort Study

Poverty Dynamics and Caries Status in Young Adolescents

Characterizing the oral microbiota of adolescents: results from the Generation R Study

Contact Info

Product

Resources

About