2014
DOI: 10.3906/vet-1302-46
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Oral and dental disorders in pet hedgehogs

Abstract: The use of Smiles rearrangement in Ugi-type couplings with tropolone allows very straightforward multicomponent formation of 2-( N , N -dialkylamino)-2,4,6-cycloheptatrien-1-one derivatives. The 4-component reaction of isocyanides, tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one), primary amines, and propionaldehyde in the presence of silica nanoparticles (silica NPs, ca. 42 nm) proceeds easily in methanol to form the title compounds in a new Ugi-Smiles-type reaction.

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Cited by 7 publications
(2 citation statements)
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“…3 They have a life expectancy of 3-4 y in the wild and 5-8 y in captivity. [1][2][3] This species is prone to develop a wide range of oral lesions, some of which can manifest as oral masses, including neoplastic and non-neoplastic growths. 3,5,7 Non-neoplastic lesions that may manifest as masses include periodontal abscesses and gingival hyperplasia (GH).…”
mentioning
confidence: 99%
“…3 They have a life expectancy of 3-4 y in the wild and 5-8 y in captivity. [1][2][3] This species is prone to develop a wide range of oral lesions, some of which can manifest as oral masses, including neoplastic and non-neoplastic growths. 3,5,7 Non-neoplastic lesions that may manifest as masses include periodontal abscesses and gingival hyperplasia (GH).…”
mentioning
confidence: 99%
“…Obesity due to overfeeding and reduced activity in captivity impairs the ability of the hedgehog to roll up and increases their vulnerability to predation after release (Fig 27). Dental problems, in particular tartar formation can develop on soft diets (Fig 28) (Chaprazov and others 2014). Both conditions are preventable by managing the diet and adding firm food, especially when animals are kept for prolonged periods (eg, over winter).…”
Section: Other Problemsmentioning
confidence: 99%