Oral and dental health in Huntington‘s disease - an observational study

Saft, Carsten; Andrich, Jürgen; Müller, Thomas; Becker, Julia C.; Jackowski, Jochen

doi:10.1186/1471-2377-13-114

Cited by 15 publications

(18 citation statements)

References 24 publications

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“…In the study conducted by Lee et al., stabilizing salivary levels of Aβ42 peptides by adding thioflavin S to prevent aggregation and using sodium azide to inhibit bacterial growth, enhanced Aβ42 detection in the sample [52] . Furthermore, the available literature indicates that patients suffering from neurological disorders have lower oral health and are more prone to oral disease than healthy individuals [307] , [308] , [309] , [310] , [311] , [312] , [313] . We thus speculate the possible interference of reduced oral health and successful biomarker detection.…”

Section: Discussionmentioning

confidence: 99%

Salivary biomarkers for the diagnosis and monitoring of neurological diseases

et al. 2018

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Current research efforts on neurological diseases are focused on identifying novel disease biomarkers to aid in diagnosis, provide accurate prognostic information and monitor disease progression. With advances in detection and quantification methods in genomics, proteomics and metabolomics, saliva has emerged as a good source of samples for detection of disease biomarkers. Obtaining a sample of saliva offers multiple advantages over the currently tested biological fluids as it is a non-invasive, painless and simple procedure that does not require expert training or harbour undesirable side effects for the patients. Here, we review the existing literature on salivary biomarkers and examine their validity in diagnosing and monitoring neurodegenerative and neuropsychiatric disorders such as autism and Alzheimer's, Parkinson's and Huntington's disease. Based on the available research, amyloid beta peptide, tau protein, lactoferrin, alpha-synuclein, DJ-1 protein, chromogranin A, huntingtin protein, DNA methylation disruptions, and micro-RNA profiles display a reliable degree of consistency and validity as disease biomarkers.

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Section: Discussionmentioning

confidence: 99%

Salivary biomarkers for the diagnosis and monitoring of neurological diseases

et al. 2018

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“…We selected a total of 22 studies (Alves et al, 2016; Azambuja et al, 2012; Boyle et al, 2008; Bradford et al, 2004; Carlozzi et al, 2021; Deniz et al, 2011; Diehl et al, 2019; Dodderi & Micheal, 2016; da Fonseca & Walker, 1993; Hamakawa et al, 2004; Hertrich & Ackermann, 1994; Hino et al, 2017; Kagel & Leopold, 1992; Keage et al, 2020; Manor et al, 2019; Oh et al, 2011; Reilmann et al, 2010; Reyes et al, 2014; Saft et al, 2013; de Tommaso et al, 2015; Vogel et al, 2012; Yoon et al, 2006), 12 research articles (Azambuja et al, 2012; Carlozzi et al, 2021; Diehl et al, 2019; Hertrich & Ackermann, 1994; Kagel & Leopold, 1992; Keage et al, 2020; Manor et al, 2019; Reilmann et al, 2010; Reyes et al, 2014; Saft et al, 2013; de Tommaso et al, 2015; Vogel et al, 2012), and 10 case reports (Alves et al, 2016; Boyle et al, 2008; Bradford et al, 2004; Deniz et al, 2011; Dodderi & Micheal, 2016; da Fonseca & Walker, 1993; Hamakawa et al, 2004; Hino et al, 2017; Oh et al, 2011; Yoon et al, 2006). The latest study was from 2021 (Carlozzi et al, 2021), while the oldest was from 1992 (Kagel & Leopold, 1992).…”

Section: Resultsmentioning

confidence: 99%

The oral manifestations of Huntington's disease: A systematic review of prevalence

et al. 2021

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Objectives:The objective of this systematic literature review was to provide a complete panorama of the oral manifestations of Huntington's disease (HD). Materials and Methods:Databases were searched, and original research studies or case report manuscripts up to May 2021 were included using keywords that describe HD combined with words related to oral health; MeSH terms were used exclusively.No time or language restrictions were applied.Results: Twenty-two investigations (12 original articles and 10 case reports) regarding oral manifestations of HD were included. The subjects examined in the selected research articles were dental health, coordination of oral structures, speech, dysphagia, and swallowing alterations. The case reports described dental treatment procedures, oromandibular dyskinesia, dysphagia, and speech alterations. Conclusions:The oral manifestations of HD were found to be associated with the advance of the disease in that the more severe the HD, the worse the alterations affecting the oral cavity. Dysphagia, dysarthria, masticatory problems, oral health impairment, and choreiform movements involving the tongue and other orofacial muscles were the main manifestations of HD in the oral cavity. The PROSPERO systematic review registration number of this study is CRD42021238934.

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“…During the hospital stay, many of our patients were treated for well‐known comorbidities and complications of HD such as gastrointestinal problems, urinary tract infections, dental complications, neurosurgical problems, or ophthalmological diseases 18–23 . Most patients in our study were discharged with the primary diagnosis of HD, dementia associated with HD, or psychiatric symptoms associated with HD undermining the debilitating influence of the disease on the patient's life.…”

Section: Discussionmentioning

confidence: 99%

Hospital Admissions of Huntington's Disease Patients in a Huntington's Disease Centre Between 2011 and 2016: A Retrospective Analysis

Peball

Heim

Ellmerer

et al. 2022

Movement Disord Clin Pract

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BackgroundBackground: Huntington's Disease (HD) is a relentlessly progressive genetic neurodegenerative disorder with characteristic motor, psychiatric, and behavioral abnormalities that inevitably results in severe disability and death. Many patients have multiple hospital admissions during the disease course, but there is limited information which problems lead to hospitalization. Objectives Objectives: To assess acute reasons for hospital admissions, discharge routes, and clinical characteristics of HD patients in a retrospective analysis. Methods Methods: We reviewed all medical records of patients with an established diagnosis of Huntington's Disease and hospital admissions between 2011 and 2016 in our local hospital-based database. ResultsResults: There were 135 hospital admissions in 53 HD patients during the review period, representing a median of two admissions per patient. Median duration of hospitalization was seven days. The most frequent reason for admission was a worsening of HD motor symptoms (n = 77, 57.0%) such as chorea, parkinsonism, gait problems, falls, and dysphagia. Psychiatric symptoms related to HD were the second most common reason for admission (n = 58, 43.0%). Infections (including aspiration pneumonia) and traumas/surgical procedures were only responsible for 6.7% and 5.9% of admissions, respectively. Emergency admissions were not common (42.2%), and the majority of patients were able to return to their previous residency upon discharge (85.2%, home or nursing home). Recurrent admissions were associated with worse motor function and functional capacity. Conclusions Conclusions: Worsening of motor and psychiatric symptoms associated with Huntington's Disease were the most common reasons for hospital admissions. Therefore, our data highlight the importance of optimal symptom control in HD patients.Huntington's Disease (HD) is an incurable neurodegenerative disorder caused by autosomal dominantly inherited elongation of cytosine-adenine-guanine (CAG) repeats in the Huntington gene on chromosome 4p16.3. Patients present with motor, behavioral, and psychiatric abnormalities, whereas the latter may appear many years before age of onset as defined by the first

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Oral and dental health in Huntington‘s disease - an observational study

Cited by 15 publications

References 24 publications

Salivary biomarkers for the diagnosis and monitoring of neurological diseases

Salivary biomarkers for the diagnosis and monitoring of neurological diseases

The oral manifestations of Huntington's disease: A systematic review of prevalence

Hospital Admissions of Huntington's Disease Patients in a Huntington's Disease Centre Between 2011 and 2016: A Retrospective Analysis

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