Oral and fecal microbiota in patients with diarrheal irritable bowel syndrome

Tang, Binbin; Hu, Yunlian; Chen, Jianhui; Su, Chengxia; Zhang, Qian; Huang, Chaoqun

doi:10.21203/rs.3.rs-1772660/v1

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…It is therefore unsurprising to find them enriched in the gut of a folivore. Yet, this genus has also been linked to gut infection, including irritable bowel syndrome and diarrhea (Tang et al, 2022). Here, the decline of Alloprevotella after FMT may be linked to the temporary resolution of the FMT recipient's abnormal fecals.…”

Section: Discussionmentioning

confidence: 99%

Fecal microbiota transplants modulate the gut microbiome of a two‐toed sloth (Choloepus didactylus)

et al. 2023

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The microbes inhabiting an animal's gastrointestinal tracts, collectively known as the gut microbiome, are vital to animal health and wellbeing. For animals experiencing gut distress or infection, modulation of the gut microbiome, for example, via fecal microbiota transplant (FMT), provides a possible disease prevention and treatment method. The beneficial microbes present in the donor's transplanted feces can help combat pathogens, assist in digestion, and rebalance the recipient's microbiota. Investigating the efficacy of FMTs in animal health is a crucial step toward improving management strategies for species under human care. We present a case study of the use of FMTs in a two‐toed sloth experiencing abnormally large, clumped, and frequent stools. We used 16 S rRNA amplicon sequencing of fecal samples to (a) compare the microbiomes of the FMT donor, a healthy, cohoused conspecific, and the FMT recipient and (b) assess the influence of multiple rounds of FMTs on the recipient's microbiome and stool consistency and frequency over time. In response to the FMTs, we found that the recipient's microbiome showed trends toward increased diversity, shifted community composition, and altered membership that more resembled the community of the donor. FMT treatment was also associated with marked, yet temporary, alleviation of the recipient's abnormal bowel movements, suggesting a broader impact on gut health. Our results provide valuable preliminary evidence that FMT treatments can augment the recipient's gut microbiome, with potential implications for animal health and management.

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Section: Discussionmentioning

confidence: 99%

Fecal microbiota transplants modulate the gut microbiome of a two‐toed sloth (Choloepus didactylus)

et al. 2023

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Oral microbiome dysbiosis and gastrointestinal diseases: a narrative review

Elghannam,

Hassanien,

Ameen

et al. 2024

Egypt Liver Journal

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Mouth is the gateway to the total body wellness. Accordingly, oral microbiome influences overall health of an individual. Oral microbiome plays a key role in shaping up the host’s health profile. Obvious differences have been reported between patients with gastrointestinal diseases and healthy controls. The oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Oral bacteria can disseminate to the distal gut via enteral or hematogenous routes. The translocation of oral microbes to the gut may give rise to a variety of gastrointestinal diseases including Helicobacter-induced diseases, irritable bowel syndrome, inflammatory bowel disease, celiac disease, and colorectal cancer. Understanding the role of the oral-to-gut microbial translocation in the pathogenesis will contribute to precise diagnosis and effective treatment. In this review, we aim to highlight the role of oral microbiota dysfunction in various gastrointestinal disorders.

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Oral and fecal microbiota in patients with diarrheal irritable bowel syndrome

Cited by 2 publications

References 29 publications

Fecal microbiota transplants modulate the gut microbiome of a two‐toed sloth (Choloepus didactylus)

Fecal microbiota transplants modulate the gut microbiome of a two‐toed sloth (Choloepus didactylus)

Oral microbiome dysbiosis and gastrointestinal diseases: a narrative review

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