1995
DOI: 10.1164/ajrccm.151.2.7842187
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Oral and inhaled corticosteroids reduce bone formation as shown by plasma osteocalcin levels.

Abstract: Osteoporosis is a well-known, serious complication of long-term high-dose corticosteroid therapy. This study was performed to determine the effects of commonly used doses of oral and inhaled steroids on biochemical indices of bone formation. Initially we examined the long-term effects of oral steroids. Thirty-four outpatients with symptomatic asthma or chronic obstructive airways disease (COAD) receiving long-term oral prednisolone (mean 10.1 mg daily) were compared with 34 control subjects with asthma or COAD… Show more

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Cited by 57 publications
(34 citation statements)
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“…There has been increasing evidence of adverse effects of inhaled corticosteroids on parameters related to bone formation, such as serum osteocalcin [32] and procollagen concentrations [33], as well as on concentrations of sex steroids, such as androgens [34], in asthmatic subjects. Bone resorption-related parameters have been reported to be increased [35], unchanged [34,36] or decreased [5].…”
Section: Discussionmentioning
confidence: 99%
“…There has been increasing evidence of adverse effects of inhaled corticosteroids on parameters related to bone formation, such as serum osteocalcin [32] and procollagen concentrations [33], as well as on concentrations of sex steroids, such as androgens [34], in asthmatic subjects. Bone resorption-related parameters have been reported to be increased [35], unchanged [34,36] or decreased [5].…”
Section: Discussionmentioning
confidence: 99%
“…For example, markers of bone turnover may reflect changes in bone metabolism induced by oophorectomy (57,125), hyperparathyroidism (126,127), Paget's disease (128), physical exercise (129), immobilisation (32,130), alcoholism (131), smoking (132), vitamin D deficiency (33,35,37,133), chronic inflammatory bowel disease (134,135), chronic starvation (136), thyroid disorders (52,137) as well as the pharmacological effects of glucocorticosteroids (48,139,140), androgens (6,7,141), gonadotropin-releasing hormone agonists (142), warfarin (143), growth hormone or insulin-like growth factors (144). Bone turnover markers may be useful in the diagnosis and management of certain of the above conditions, but in most cases has not been rigorously examined.…”
Section: Other Conditionsmentioning
confidence: 99%
“…renal osteodystrophy, hyperparathyroidism, hyperthyroidism, and Paget's disease (35,36) and decreased concentrations with low bone turnover, e.g. hypoparathyroidism, hypercalcemia resulting from bone metastases, and longterm corticosteroid therapy, the latter reflecting a decrease in the osteoblastic activity (37). While the role of osteocalcin changes in children with sleep-disordered breathing remains to be established, Colle and colleagues (38) identified increased nocturnal osteocalcin levels among children with growth retardation, possibly as a compensatory response.…”
Section: Discussionmentioning
confidence: 99%