Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis

Silbergleit, Matthew; Vasquez, Adrian A.; Miller, Carol J.; Sun, Jun; Kato, Ikuko

doi:10.1016/bs.pmbts.2020.02.004

Cited by 23 publications

(19 citation statements)

References 287 publications

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“…Growing pieces of evidence have pointed towards more severity of infections due to the resistant strains of S . enterica [ 33 ]. The streptomycin and spectinomycin belong to aminocyclitol and aminoglycoside families of antibiotics, respectively, and bind to the bacterial ribosome and interfere with the protein biosynthesis.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Plant Antimicrobial Peptides against Selected Pathogenic Bacterial Species Using a Peptide-Protein Docking Approach

Mustafa

Mehmood

Mahrosh

et al. 2022

BioMed Research International

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Antimicrobial resistance is the key threat to global health due to high morbidity and mortality. The alteration of bacterial proteins, enzymatic degradation, and change of membrane permeability towards antimicrobial agents are the key mechanisms of antimicrobial resistance. Based on the current condition, there is an urgent clinical need to develop new drugs to treat these bacterial infections. In the current study, the binding patterns of selected antimicrobial peptides (AMPs) with different multidrug-resistant bacterial strains have been analyzed. Among ten selected AMPs in this study, napin and snakin-1 exhibited the best scores and binding patterns. Napin exhibited strong interactions with penicillin-binding protein 1a of Acinetobacter baumannii (with a binding score of -158.7 kcal/mol and ten hydrogen bonds), with glucose-1-phosphate thymidylyltransferase of Mycobacterium tuberculosis H37Rv (with a binding score of -107.8 kcal/mol and twelve hydrogen bonds), and with streptomycin 3 ″ -adenylyltransferase protein of Salmonella enterica (with a binding score of -84.2 kcal/mol and four hydrogen bonds). Similarly, snakin-1 showed strong interactions with oxygen-insensitive NADPH nitroreductase of Helicobacter pylori (with a binding score of -105.0 kcal/mol and thirteen hydrogen bonds) and with penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus (with a binding score of -103.8 kcal/mol and twenty-three hydrogen bonds). The docking results were further validated by molecular dynamics simulations. The results of this computational approach support the evidence of efficiency of these AMPs as potent inhibitors of these specific proteins of bacterial strains. However, further validations are required to fully evaluate the potential of selected AMPs as drug candidates against these resistant bacterial strains.

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Section: Resultsmentioning

confidence: 99%

Investigation of Plant Antimicrobial Peptides against Selected Pathogenic Bacterial Species Using a Peptide-Protein Docking Approach

Mustafa

Mehmood

Mahrosh

et al. 2022

BioMed Research International

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“…A few other periodontal pathogens with potential oncogenic properties include Treponema denticola (Td), Aggregatibacter actinomycetemcomitans (Aa) and Fusobacterium nucleatum (Fn). While the association with head and neck cancer in humans has been only demonstrated for Td [ 25 , 28 ], Aa and Fn have positive findings from animal studies in other organ systems [ 28 ]. Td and its exotoxin, Dentilisin (chymotrypsin-like protease (CTLP)) have been shown to possess the ability to activate mitogen-activated protein kinase (MAP kinase) signalling pathways controlling cell proliferation and survival, as well as to MMPs promoting immunomodulation and tumour invasion [ 29 , 30 ].…”

Section: Head and Neck Cancermentioning

confidence: 99%

“…These toxicity/responses have been mainly ascribed to CDT, a genotoxin as discussed in an earlier section for head and neck cancer, because most enterohepatic species of Helicobacter , including H. pullorum and H. hepaticus , are known to harbour genes encoding CDT, such as CdtB [ 210 ]. More details about its chemical and biological properties can be found in a separate review [ 28 ]. CDT may not only contribute to genomic mutations also caused by HCV but also promote HCV persistence through suppression of innate and adaptive immunity [ 211 ].…”

Section: Liver Cancermentioning

confidence: 99%

Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence

Kato

Zhang

Sun

2022

Cancers

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Infectious agents, including viruses, bacteria, fungi, and parasites, have been linked to pathogenesis of human cancers, whereas viruses and bacteria account for more than 99% of infection associated cancers. The human microbiome consists of not only bacteria, but also viruses and fungi. The microbiome co-residing in specific anatomic niches may modulate oncologic potentials of infectious agents in carcinogenesis. In this review, we focused on interactions between viruses and bacteria for cancers arising from the orodigestive tract and the female genital tract. We examined the interactions of these two different biological entities in the context of human carcinogenesis in the following three fashions: (1) direct interactions, (2) indirect interactions, and (3) no interaction between the two groups, but both acting on the same host carcinogenic pathways, yielding synergistic or additive effects in human cancers, e.g., head and neck cancer, liver cancer, colon cancer, gastric cancer, and cervical cancer. We discuss the progress in the current literature and summarize the mechanisms of host-viral-bacterial interactions in various human cancers. Our goal was to evaluate existing evidence and identify gaps in the knowledge for future directions in infection and cancer.

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“…[60] We have demonstrated that Salmonella-epithelial interactions also influence ß-catenin signaling and its upstream regulator Wnt in infection and development of CRC. [53,[61][62][63][64][65] Fusobacterium nucleatum is among the significantly enriched bacteria in stools and tissue biopsies of patients with CRC. [66,67] F. nucleatum promotes intestinal tumorigenesis through stimulating the b-catenin signaling via its FadA adhesin.…”

Section: Microbial Post-translational Modifications and Carcinogenesismentioning

confidence: 99%

Impact of bacterial infection and intestinal microbiome on colorectal cancer development

Sun

2022

Chinese Medical Journal

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Accumulating evidence suggests that intestinal bacteria play an important role in the pathogenesis of colorectal cancer (CRC). Due to the complexity of the intestinal microbiome, identification of the specific causative microbial agents in CRC remains challenging, and the search for the causative microbial agents is intense. However, whether bacteria or their products can induce inflammation that results in tumorigenesis or directly causes CRC in humans is still not clear. This review will mainly focus on the progress of bacterial infection and CRC, and introduce the microbial contribution to the hallmarks of cancer. This article uses Salmonella and its chronic infection as an example to investigate a single pathogen and its role in the development of CRC, based on laboratory and epidemiological evidence. The bacterial infection leads to an altered intestinal microbiome. The review also discusses the dysfunction of the microbiome and the mechanism of host–microbial interactions, for example, bacterial virulence factors, key signaling pathways in the host, and microbial post-translational modifications in the tumorigenesis. Colonic carcinogenesis involves a progressive accumulation of mutations in a genetically susceptible host leading to cellular autonomy. Moving forward, more human data are needed to confirm the direct roles of bacterial infection in CRC development. Insights into the inhibiting infection will help to prevent cancer and develop strategies to restore the balance between host and microorganisms.

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Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis

Cited by 23 publications

References 287 publications

Investigation of Plant Antimicrobial Peptides against Selected Pathogenic Bacterial Species Using a Peptide-Protein Docking Approach

Investigation of Plant Antimicrobial Peptides against Selected Pathogenic Bacterial Species Using a Peptide-Protein Docking Approach

Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence

Impact of bacterial infection and intestinal microbiome on colorectal cancer development

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