Oral and intravenous glucose administration elicit opposing microvascular blood flow responses in skeletal muscle of healthy people: role of incretins

Abstract

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Gastric inhibitory polypeptide as the new candidate for the interaction of skeletal muscle blood flow and glucose disposal

“…Traditionally, the hormones that have received the most attention are insulin and GLP-1, but maybe the importance of a previously underappreciated incretin, gastric inhibitory polypeptide (GIP) has been overlooked. Roberts-Thomson et al (2022), published in this issue of The Journal of Physiology, contribute to this suggestion by revealing opposite vascular responses and related hormone release in response to glucose depending on route of administration.…”

“…Recent findings by Roberts‐Thomson et al . (2022), published in this issue of The Journal of Physiology , contribute to this suggestion by revealing opposite vascular responses and related hormone release in response to glucose depending on route of administration.…”

“…Roberts‐Thomson et al . (2022) compared the skeletal muscle micro‐ and macrovascular responses to an oral glucose tolerance test (OGTT) and an intravenous glucose tolerance test (IVGTT) in healthy individuals ( n = 10 4/6, M/F). The aim was to identify potential gut‐derived hormones that could help explain the contradictory MBF response apparently dependent on the route of glucose administration.…”

Sweet release – intravenous, not oral, glucose administration increases microvascular blood flow

“…Roberts‐Thomson et al . (2022) report opposing microvascular responses dependent on glucose administration route, revealing only orally ingested glucose results in impaired microvascular blood flow and point to incretin hormones, GLP‐1 and GIP, partially mediating vascular outcomes. These results fill a critical knowledge gap surrounding post‐prandial blood flow regulation and appear to exclude hyperglycaemia as the mechanism of impairment.…”

“…Recently published in The Journal of Physiology , Roberts‐Thomson et al . (2022) addressed the disparate vascular responses to hyperglycaemia administered orally or intravenously. With a non‐randomized cross‐over design, participants first underwent a standard 75 g oral glucose tolerance test with microvascular blood flow measured via contrast‐enhanced ultrasound at baseline, 60 and 120 min, while measuring incretin and insulin responses throughout.…”