Oral and serum IL-6 levels in oral lichen planus patients

Gu, Gao Man; Martin, Michael D.; Darveau, Richard P.; Truelove, Edmond L.; Epstein, Joel B.

doi:10.1016/j.tripleo.2004.05.006

Cited by 44 publications

(38 citation statements)

References 27 publications

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“…There were statistically significant differences of serum IL-18 between control/NEOLP, control/ EOLP, and NEOLP/EOLP groups. mucosa and the blood cells results in initiation and perpetuation, including TNF-α, IL-2, IL-4, IL-8, and IL-10 [14][15][16][17]. Clearly, imbalances in pro-and antiinflammatory cytokine production along with imbalance on Th2 and Th1 immune responses are proposed to increase the susceptibility for OLP [18].…”

Section: Discussionmentioning

confidence: 99%

Salivary and Serum Interleukin-18 in Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

et al. 2011

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The purpose of this study was to investigate the potential pro-inflammatory role of the cytokine interleukin (IL-18) in oral lichen planus (OLP) so as to provide a reliable and early indicator for the diagnosis of OLP. One hundred three ethnic Chinese patients with OLP were enrolled in this study, as were 48 age- and sex-matched controls. IL-18 concentrations in serum and saliva were screened by enzyme-linked immunosorbent assay. The protein content was expressed as picograms per milliliter. OLP patients showed a high-level of IL-18 expression profile in serum compared with the control group (OLP = 21.32 ± 8.26 pg/mL, control = 12.29 ± 5.11 pg/mL, P < 0.05), and the saliva partner had significantly higher concentrations of IL-18 compared to the control (OLP = 20.12 ± 5.78 pg/mL, control = 15.60 ± 4.17 pg/mL, P < 0.05). In patients with OLP, serum and salivary IL-18 are elevated, correlating with the severity of illness. These findings may be considered to improve the predictive or prognostic values of inflammatory cytokines for OLP and also to design possible novel therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Salivary and Serum Interleukin-18 in Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

et al. 2011

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“…Elevated serum IL‐6 levels have been observed in patients with OLP or LP. It has been suggested that IL‐6 promotes the proliferation of keratinocytes and has been related to the process of epithelial hyperplasia seen in lichen planus . Neopterin is regarded as a valuable marker of the cytotoxic activity of T lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐6 and neopterin levels in the serum and saliva of patients with Lichen Planus and oral Lichen Planus

Abdel-Haq

Kuśnierz-Cabała

Darczuk

et al. 2014

J Oral Pathology Medicine

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“…Elevations in interleukin 6 (IL6) IL1β, IL1α, IL1 receptor antagonist, tumor necrosis factor alpha (TNFα), soluble TNF-receptor II, monocyte chemoattractant protein-1, and soluble B cell activating factor are associated with autoimmune or chronic inflammatory diseases that clinically parallel cGVHD (18,19,20,21,22,23,24,25). Several of these immune activity mediators are candidate biomarkers of cGVHD activity (15, 16).…”

Section: Introductionmentioning

confidence: 99%

Oral Symptom Intensity, Health-Related Quality of Life, and Correlative Salivary Cytokines in Adult Survivors of Hematopoietic Stem Cell Transplantation with Oral Chronic Graft-versus-Host Disease

Fall‐Dickson

Mitchell²,

Marden

et al. 2010

Biology of Blood and Marrow Transplantation

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Oral chronic graft-versus-host disease (cGVHD) is a frequent, clinically significant sequela of allogeneic hematopoietic stem cell transplant (HSCT). This study was designed to elucidate relationships among clinical characteristics of oral cGVHD and related oral pain and oral dryness, salivary proinflammatory cytokine IL6 and IL1α concentrations, and health-related quality of life (HRQL). An understanding of the characteristics and correlates of oral cGVHD manifestations and related symptoms such as dryness is fundamental to the development of therapeutic interventions. Methods: Oral cGVHD severity was assessed with the Oral Mucositis Rating Scale (OMRS). Oral pain and perceived oral dryness intensity were self-reported via a visual analogue scale and a numeric rating scale respectively. HRQL was assessed with the Functional Assessment of Cancer Therapy-General (FACT-G). Salivary IL1α and IL6 concentrations were measured by enzyme-linked immunosorbent assay (R & D Systems, Minneapolis, MN). Results: All 42 adult subjects (male 59%) had clinician-assessed oral cGVHD by OMRS scale (mean = 18.38 ± 12.99; range = 2 to 46). Oral dryness (43%) (mean = 2.56 ± 3.45; range = 0 to 10) was more prevalent than oral pain (8%) (mean = 0.13 ± 0.47). Salivary IL6 was associated with oral cGVHD severity (r = .49; p < .01), oral ulceration (r = .38; p = .04), and erythema (r = .63; p < .01). FACT-G total, and physical and emotional well-being subscale scores were meaningfully lower than US population normative values. Participants with more severe oral cGVHD manifestations had significantly inferior social/family well-being (r = −.49; p < .01). Oral dryness was associated with higher salivary IL1α (r = .41; p = .04), and controlling for cGVHD severity, with lower health-related quality of life (r = −.41; p = .03). Subjects with moderate to severe oral dryness tended to report the poorest overall HRQL. This study provides preliminary evidence of the relationship between oral dryness and HRQL, the contribution of oral cGVHD to inferior HRQL, and the association between IL6 and oral cGVHD overall severity, ulceration and erythema. The high prevalence of oral dryness and its relationship to HRQL in a sample of patients with oral cGVHD underscores the importance of improving our evaluation and management of this symptom in long-term survivors of allogeneic HSCT. The positive association seen between IL6 and oral sGVHD overall severity, and erythema, as well as the positive trend seen with oral ulceration, warrant further exploration of this cytokine as a potential biomarker of active oral cGVHD.

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Oral and serum IL-6 levels in oral lichen planus patients

Cited by 44 publications

References 27 publications

Salivary and Serum Interleukin-18 in Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

Salivary and Serum Interleukin-18 in Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

Interleukin‐6 and neopterin levels in the serum and saliva of patients with Lichen Planus and oral Lichen Planus

Oral Symptom Intensity, Health-Related Quality of Life, and Correlative Salivary Cytokines in Adult Survivors of Hematopoietic Stem Cell Transplantation with Oral Chronic Graft-versus-Host Disease

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