Oral angiosarcoma misdiagnosed as a pyogenic granuloma

Oral and Salivary Gland Angiosarcoma: A Clinicopathologic Study of 29 Cases

“…Another patient with a buccal mucosa angiosarcoma, reported by Maddox and Evans (2), recurred, but the patient did well after excision of the recurrence, with no evidence for metastasis; this patient fared much better than the skin primary angiosarcomas in the same series. Therefore, the variable length follow-up, when available in these patients (4), was all relatively good, with the exception of a few cases (1,18,21), including one with a 7-cm submandibular area tumor (21) that may have started in the soft tissue outside of the gland and another patient who also had a carcinoma of the floor of the mouth (1).…”

“…In the literature, we found only 10 cases of metastatic angiosarcoma to the oral cavity, including 8 cases to gingiva (1,7,9,11,17,18,22,24) and 2 to tongue (8,19). To our knowledge, no cases of metastatic angiosarcoma to the salivary glands have been reported previously in the English-language literature, whereas the current study has three metastatic angiosarcomas to salivary gland.…”

“…To our knowledge, no cases of metastatic angiosarcoma to the salivary glands have been reported previously in the English-language literature, whereas the current study has three metastatic angiosarcomas to salivary gland. Previously reported metastatic tumors to oral locations have been primary from skin and subcutaneous tissue (7,19), breast (9,17,24), lung, kidney, bone (1,17,22), colon, and uterus (11). The patients in the literature with angiosarcoma metastases to oral locations had overall poor prognosis, with metastases (17,22,24) or death from disease, generally caused by respiratory compromise or bleeding, within less than 1 to 15 months (1, 7-9, 11, 18, 19).…”

“…Angiosarcoma generally occurs in the skin and subcutis or skeletal muscle and has been described in the spleen, bone, liver, and breast (1). Oral and salivary gland area angiosarcomas are extremely rare, comprising only 2% of a series of all angiosarcomas (2) and 0.6 to 30% of series or reviews of published head and neck angiosarcomas (excluding scalp) (3)(4)(5).…”

“…Oral and salivary gland area angiosarcomas are extremely rare, comprising only 2% of a series of all angiosarcomas (2) and 0.6 to 30% of series or reviews of published head and neck angiosarcomas (excluding scalp) (3)(4)(5). Oral and salivary gland angiosarcomas are mostly presented as single case reports (1,2,. Larger head and neck sarcoma studies failed to reveal which angiosarcomas have oral locations (26).…”