Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination-a model for inhibition of angiotensin II–induced cutaneous inflammation

Munavalli, Girish Gilly; Knutsen-Larson, Siri; Lupo, Mary P.; Geronemus, Roy G.

doi:10.1016/j.jdcr.2021.02.018

Cited by 75 publications

(142 citation statements)

References 19 publications

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“… 41 By blocking the production of angiotensin II and thus reducing the substrate for ACE2, ACE inhibitors (ACE-I) in effect promote an anti-inflammatory response. 39 , 40 Indeed, upon initiation with oral lisinopril, all DIRs resolved completely within 24-72 hours. 39 , 40 Despite the success of ACE-Is in treating DIRs, further research on the proposed mechanism of action is warranted.…”

Section: Introductionmentioning

confidence: 96%

“…Among the known triggers of DIRs to fillers include viral illness, low-quality products, dental procedures, influenza vaccines and most recently, COVID-19 vaccines. 4 , 39 , 40 To date, 15 cases have been reported across three observational studies. Of these reports, 11 (73%) are associated with the mRNA-1273 vaccine and four (27%) are associated with the BNT162b2 vaccine ( Table 3 ).…”

Section: Introductionmentioning

confidence: 99%

“… 40 These reactions developed rapidly, often within 24 to 48 hours and presented as swelling and inflammation focused around areas previously treated with fillers. 39 , 40 Most cases were recalcitrant to antihistamines, hyaluronidase and acetaminophen. 39 , 40 …”

Section: Introductionmentioning

confidence: 99%

“…Previous research revealed high expression of angiotensin converting enzyme (ACE) 2 receptors in adipose tissue, where most fillers are injected. 40 These receptors are targeted by the SARS-CoV-2 spike protein and the resulting interaction in the skin releases a pro-inflammatory cascade, which may explain the DIRs to HA fillers seen in COVID-infection. 41 By blocking the production of angiotensin II and thus reducing the substrate for ACE2, ACE inhibitors (ACE-I) in effect promote an anti-inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 Vaccines and the Skin

Sun

Fathy

McMahon

et al. 2021

Dermatologic Clinics

108

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: In 2021, we entered a new phase of the COVID-19 pandemic. As mass vaccinations are underway and more vaccines are approved, it is increasingly important for dermatologists to recognize potential cutaneous adverse events. In this article we review the dermatologic manifestations of COVID-19 vaccines worldwide as reported in clinical trial data and summarize additional observational reports of skin reactions to COVID-19 vaccines. Early-onset local injection reactions were the most common cutaneous side effects observed in clinical trials, while delayed injection reactions were the most common cutaneous side effect reported outside of clinical trials. Understanding the landscape of cutaneous manifestations to COVID-19 vaccines is key to providing appropriate vaccine guidance.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

COVID-19 Vaccines and the Skin

Sun

Fathy

McMahon

et al. 2021

Dermatologic Clinics

108

View full text Add to dashboard Cite

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“…This reaction was observed in patients who received hyaluronic acid (HA) filler injections as facial "rejuvenation" treatment. It was characterized by the appearance of facial edema and erythema [11][12].…”

Section: Discussionmentioning

confidence: 99%

BCG Scar Local Skin Inflammation as a Novel Reaction Following mRNA COVID-19 Vaccines in Two International Healthcare Workers

Lopatynsky-Reyes¹,

Acosta-Lazo²,

Ulloa‐Gutiérrez³

et al. 2021

Cureus

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Viral Infections

Harwood,

Sterling

2024

Rook's Textbook of Dermatology

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Viruses can cause disease in the skin or mucosa by direct infection or, via a systemic infection, produce secondary skin abnormalities. The chapter reviews the viruses associated with skin lesions, outlining the pathophysiology, the clinical features, diagnostic methods and the approaches to treatment. Primary skin infection following direct contact occurs with poxviruses, some herpesviruses and papillomaviruses leading to visible features which may be readily diagnostic. Less specific skin changes are seen with systemic infections, when infection is often via mucosae or inoculation, for example with parvovirus, measles or coronavirus and for these infections, diagnosis will usually involve body fluid analysis.

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Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination-a model for inhibition of angiotensin II–induced cutaneous inflammation

Cited by 75 publications

References 19 publications

COVID-19 Vaccines and the Skin

COVID-19 Vaccines and the Skin

BCG Scar Local Skin Inflammation as a Novel Reaction Following mRNA COVID-19 Vaccines in Two International Healthcare Workers

Viral Infections

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