Oral antibiotics for chronic blepharitis

Onghanseng, Neil; Ng, Sueko M; Halim, Muhammad Sohail; Nguyen, Quan Dong

doi:10.1002/14651858.cd013697.pub2

Cited by 16 publications

(26 citation statements)

References 48 publications

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“…Blepharitis is a quite common ocular condition in older patients. 17 This condition is often associated with concomitant ophthalmic complications, potentially exacerbating each other and making the treatment more challenging in terms of duration. Previous data report that eyelid complications may last for many months.…”

Section: Discussionmentioning

confidence: 99%

“…15 , 16 Blepharitis is a common chronic ocular surface disease that involves 37–47% of patients referring to ophthalmologists and optometrists, causing significant discomfort and symptoms that include redness, itching, burning, foreign body sensations and blurred vision. 17 , 18 Although bacteria may or may not initiate blepharitis, the oily and inflamed eyelid margins of patients with blepharitis are frequently colonized by bacteria. The main treatments for blepharitis are topical and/or systemic antibiotic therapies for bacterial aetiologies combined with topical steroids.…”

Section: Introductionmentioning

confidence: 99%

“…Some experiences from clinical practice emerged during the discussion and suggested that adjuvant treatment with the HOCl ophthalmic spray resulted in a shortening of the time to clinical resolution of blepharitis, particularly in relation to the ophthalmic complications that often come with blepharitis diagnosis, according to the literature. 17 In addition, in clinical practice, adjuvant treatment with the HOCl ophthalmic spray resulted in a viable option for managing ophthalmic disorders other than blepharitis. In the following paragraphs, some real-life experiences with the use of the HOCl ophthalmic spray are presented and discussed to further characterize the use of HOCl for ophthalmic applications.…”

Section: Introductionmentioning

confidence: 99%

“…The main treatments for blepharitis are topical and/or systemic antibiotic therapies for bacterial aetiologies combined with topical steroids. 17 However, many individuals with blepharitis require long-term ISSN: 1740-4398 CASE SERIES -HOCl for the management of eye infections drugsincontext.com therapy as blepharitis is chronic, and relief of symptoms may be temporary.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The role of hypochlorous acid in the management of eye infections: a case series

Bertone¹,

Mollicone²,

Russo³

et al. 2022

DIC

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Experiences from clinical practice suggest that hypochlorous acid (HOCl) used as adjuvant treatment can shorten the time to clinical resolution of blepharitis, particularly in relation to the ophthalmic complications that often occur with a blepharitis diagnosis. In addition, in clinical practice, HOCl adjuvant treatment also resulted in a viable option for the management of ophthalmic disorders other than blepharitis. This case series presents and discusses real-life experiences with using an HOCl ophthalmic spray to manage eye infections, further characterizing the use of HOCl for ophthalmic applications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The role of hypochlorous acid in the management of eye infections: a case series

Bertone¹,

Mollicone²,

Russo³

et al. 2022

DIC

View full text Add to dashboard Cite

show abstract

“…In general, clinicians should strive to use the least amount of this antibiotic in order to still maintain therapeutic effect. A recent Cochrane database review concluded that there was insufficient evidence to draw any meaningful conclusions on the use of oral antibiotics for chronic blepharitis [ 62 ].…”

Section: Oral Agentsmentioning

confidence: 99%

Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets

Dang

Riaz

Karamichos

2022

Drugs

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Corneal injuries can occur secondary to traumatic, chemical, inflammatory, metabolic, autoimmune, and iatrogenic causes. Ocular infection may frequently occur concurrent to corneal injury; however, antimicrobial agents are excluded from this present review. While practitioners may primarily rely on clinical examination techniques to assess these injuries, several pharmacological agents, such as fluorescein, lissamine green, and rose bengal, can be used to formulate a diagnosis and develop effective treatment strategies. Practitioners may choose from several analgesic medications to help with patient comfort without risking further injury or delaying ocular healing. Atropine, cyclopentolate, scopolamine, and homatropine are among the most frequently used medications for this purpose. Additional topical analgesic agents may be used judiciously to augment patient comfort to facilitate diagnosis. Steroidal anti-inflammatory agents are frequently used as part of the therapeutic regimen. A variety of commonly used agents, including prednisolone acetate, loteprednol, difluprednate, dexamethasone, fluorometholone, and methylprednisolone are discussed. While these medications are effective for controlling ocular inflammation, side effects, such as elevated intraocular pressure and cataract formation, must be monitored by clinicians. Non-steroidal medications, such as ketorolac, bromfenac, nepafenac, and diclofenac, are additionally used for their efficacy in controlling ocular inflammation without incurring side effects seen with steroids. However, these agents have their own respective side effects, warranting close monitoring by clinicians. Additionally, ophthalmologists routinely employ several agents in an off-label manner for supplementary control of inflammation and treatment of corneal injuries. Patients with corneal injuries not infrequently have significant ocular surface disease, either as a concurrent pathology or as an exacerbation of previously existing disease. Several agents used in the management of ocular surface disease have also been found to be useful as part of the therapeutic armamentarium for treatment of corneal injuries. For example, several antibiotics, such as doxycycline and macrolides, have been used for their anti-inflammatory effects on specific cytokines that are upregulated during acute injuries. There has been a recent wave of interest in amniotic membrane therapies (AMTs), including topical, cryopreserved and dehydrated variants. AMT is particularly effective in ocular injuries with violation of corneal surface integrity due to its ability to promote reepithelialization of the corneal epithelium. Blood-based therapies, including autologous serum tears, plasma-enriched growth factor eyedrops and autologous blood drops, have additionally been explored in small case series for effectiveness in challenging and recalcitrant cases. Protection of the ocular surface is also a vital component in the treatment of corneal injuries. Temporary protective methods, such as bandage contact lenses and me...

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Evaluating the Evidence for Treatment of Meibomian Gland Dysfunction With Oral Antibiotics

Melia

2023

JAMA Ophthalmol

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In this issue of JAMA Ophthalmology, Upaphong et al 1 report the results of a high-quality equivalence clinical trial comparing the efficacy of a 3-week course of weekly oral azithromycin with that of a 6-week course of oral doxycycline for treatment of moderate to severe meibomian gland dysfunction (MGD), showing that the 2 treatments are equivalent with respect to total MGD score and ocular surface disease index at both 6 and 8 weeks of follow-up.MGD is a common chronic ocular disorder commonly characterized by hyposecretion of meibum, an oily substance that stabilizes the tear film of the eye, changes in meibum quality, and epithelial duct cell hyperkeratinization leading to obstruction of the duct. It is associated with an array of signs and symptoms, including blepharitis, chalazion, meibomitis, and ocular surface damage. 2 Initial treatment typically consists of warm compresses, eyelid scrubs, artificial tears, topical antibiotic, topical steroid, and/or other anti-inflammatory agents. In more severe cases and cases not responding to conservative treatment, an oral antibiotic frequently is prescribed. Recent reviews have noted that although there have been multiple clinical studies evaluating antibiotic treatment for MGD, there are no highquality randomized clinical trials (RCTs) supporting their use. [3][4][5] Major issues with prior RCTs include high attrition, selective reporting, and small sample sizes with low precision and wide confidence intervals on treatment effects. [3][4][5]

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Oral antibiotics for chronic blepharitis

Cited by 16 publications

References 48 publications

The role of hypochlorous acid in the management of eye infections: a case series

The role of hypochlorous acid in the management of eye infections: a case series

Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets

Evaluating the Evidence for Treatment of Meibomian Gland Dysfunction With Oral Antibiotics

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