Oral Antihyperglycemic Therapy for Type 2 Diabetes

Abstract

With few exceptions, the available oral antidiabetic agents are equally effective at lowering glucose concentrations. Their mechanisms of action are different, however, and as a result they appear to have distinct metabolic effects. These are reflected in their adverse effect profiles and their effect on cardiovascular risk, which may influence drug choice.

Efficacy and safety of liraglutide compared to sulphonylurea during Ramadan in patients with type 2 diabetes (LIRA‐Ramadan): a randomized trial

“…The dose of sulphonylureas in this trial was, however, consistent with or higher than doses used in other Ramadan trials, as well as in clinical practice 9, 10, 11, 31, 32, 33, 34. Generally, for sulphonylureas administered at higher than half the maximum approved dose, the glucose‐lowering effect levels off as the dose increases 35. However, theoretically, if the physician had chosen to increase the dose of sulphonylurea for patients on a dose lower than the maximum approved dose, the hypoglycaemia rate in the sulphonylurea group would probably have been higher during Ramadan.…”

Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy

“…Whether used alone or in combination with other blood glucose-lowering interventions, the increased number of choices available to practitioners and patients has heightened uncertainty regarding the most appropriate means of treating this widespread disease [14]. Although numerous reviews on the management of type 2 diabetes have been published in recent years [15][16][17], practitioners are often left without a clear pathway of therapy to follow. We developed the following consensus approach to the management of hyperglycaemia in the non-pregnant adult to help guide healthcare providers in choosing the most appropriate interventions for their patients with type 2 diabetes.…”

A study on the hypoglycemic and hypolipidemic effects of an ayurvedic drug Rajanyamalakadi in diabetic patients

“…Currently enormous research interest is centered world wide about the search for newer, cheaper, and safer herbal based formulations which can effectively normalize the metabolic derangement underlying the onset of clinical diabetes. Recent scientific investigations have confirmed the efficacy of many of the ayurvedic preparations, some of which are remarkably effective, relatively nontoxic and have substantial documentation of efficacy (2,4).…”