Oral Antiplatelet Therapy in Acute Coronary Syndromes, Clinical Experience in an Emergency Hospital With Percutaneous Coronary Intervention Facilities

Babeş, Elena Emilia

doi:10.31925/farmacia.2021.5.14

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…20.7%, which is similar to the share reported in the ICE cohort study and in the Euro Heart Survey, 23% and 18%, respectively [48,60]. Our clinical study reported cerebral manifestations such as strokes in 63.15% of patients, with embolic events correlated with Staphylococcus aetiology and large vegetations despite proper therapy [3,4]. Early identification of patients at risk of developing septic shock is mandatory in order to improve the outcome.…”

Section: Conssupporting

confidence: 85%

Current Data About the Aetiology and Treatment of Infective Endocarditis

Zaha¹

2022

FARMACIA

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The aim of this study was to provide current data on the incidence, the aetiology and the treatment of infective endocarditis (IE) in a group of patients from one centre over a period of ten years. Our study includes data from patients over the age of 18, diagnosed with bacterial endocarditis, over a period of 10 years (January 2010 -December 2019. The data analysed pertains to clinical presentation, lab results, medical imaging, treatment and outcome during hospitalization. A total of 92 cases were included, with an age average of 63.80 ± 13.45 years, and a male/female ratio of 1.13. Most patients had endocarditis on native valves. Native valve IE was more frequent on the mitral valve, while in cases with prosthetic valves, the aortic valve was more frequently affected. A large number of patients had comorbidities and healthcare-associated IE. Negative blood cultures were recorded in 30.43% of the cases, probably due to the administration of antimicrobials before blood cultures were drawn. Gram-positive pathogens were predominant in terms of aetiology. Staphylococcus aureus and coagulase negative staphylococci (CoNS) were the most commonly isolated microorganisms, a large number of which were methicillin-resistant. The Charlson comorbidity index was higher in IEs caused by Enterococcus spp., and in those cases the patients were also older. Seven patients had positive cultures for Streptococcus spp., less frequently isolated than Staphylococcus spp., but showing the best antibiotic susceptibility rates. The main etiologic agent involved in healthcareassociated infective endocarditis was Staphylococcus aureus, followed by CoNS. Despite the best diagnostic and treatment options, the mortality rate remained high (33.7%). An increased incidence of Staphylococcus spp. as an etiological agent was found and this was correlated with complications and increased mortality. RezumatScopul acestui studiu a fost de a furniza date actuale despre incidența, etiologia și tratamentul endocarditei infecțioase (EI) la un grup de pacienți dintr-un singur centru timp de zece ani. Studiul nostru include date de la pacienți cu vârsta peste 18 ani diagnosticați cu endocardită bacteriană pe o perioadă de 10 ani (ianuarie 2010 -decembrie 2019). Au fost analizate datele privind aspectele clinice, de laborator, imagistice, tratamentul și evoluția din timpul spitalizării. Un număr total de 92 de cazuri au fost incluse cu o vârstă medie a grupului de 63.80 ± 13.45 ani, cu un raport bărbați/femei de 1.13. Majoritatea pacienților au avut endocardită pe valva nativă. Endocardita infecţioasă pe valvă nativă a fost mai frecventă pe valva mitrală iar dintre valvele protetice cea aortică a fost mai frecvent afectată. Un număr mare de pacienți au avut comorbidități și EI asociată asistenței medicale. Hemoculturi negative au fost înregistrate la 30.43% dintre pacienți, probabil din cauza administrării de antimicrobiene înainte de recoltarea hemoculturilor. Etiologia a fost dominată de germenii Gram pozitivi. Staphylococcus aureus și stafilococii coagul...

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Section: Conssupporting

confidence: 85%

Current Data About the Aetiology and Treatment of Infective Endocarditis

Zaha¹

2022

FARMACIA

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“…Most patients with AMI need coronary intervention, and intervention treatment will cause a certain degree of damage to vascular endothelial cells and adverse effects on the tissue cells of patients, causing myocardial necrosis of patients and even heart failure, which has an adverse effect on the prognosis of coronary intervention. Thus, drugs need to be taken to protect the vascular endothelium and alleviate the disease [12][13][14]. Sacubitril/valsartan can greatly inhibit ventricular remodelling and has high adoption value.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Ultrasound-Based Preoperative Exogenous Sacubitril/Valsartan on the Heart and Kidney of Patients Undergoing Percutaneous Coronary Intervention

WANG

2023

FARMACIA

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This research aimed to demonstrate the protective effects of exogenous sacubitril/valsartan on the heart and kidney of patients undergoing percutaneous coronary intervention (PCI) preoperatively based on ultrasound. Three hundred patients undergoing PCI in our hospital were assigned to a control (Ctrl) group (150 patients receiving valsartan preoperatively) and a research (Res) group (150 patients receiving sacubitril/valsartan preoperatively). The myocardial injury, cardiac function (CF), renal function (RF) and complications of the two groups were compared preoperatively and postoperatively. The results showed that the troponin I (cTnI) and creatine kinase isoenzyme myocardial bands (CK-MB) in the two groups showed a decreasing trend postoperatively, and that of the Res group was more significant (p < 0.05). Postoperatively, the left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) of the two groups of patients decreased, being more significant in the Res group (p < 0.05). Postoperatively, blood urea nitrogen (BUN) and creatinine (Cr) in the two groups were decreased, the trend being more evident in the Res group (p < 0.05). The drug efficiency in the Ctrl group and Res group was 84.67% and 93.33%, respectively, and the effective rate of drugs in the Res group was y higher (p < 0.05). In summary, ultrasonography had a positive adoption value in evaluating the treatment effect of coronary intervention, and exogenous sacubitril/valsartan had an important protective effect on the heart and kidneys of patients undergoing PCI. RezumatÎn cadrul acestui studiu au fost investigate efectele protectoare exogene ale sacubitril/valsartan asupra inimii și rinichilor la pacienții supuși intervenției coronariene percutanate (ICP), preoperator, pe baza ecografiei. Un număr de trei sute de pacienți supuși ICP au fost repartizați astfel: un grup de control (Ctrl) (150 de pacienți care au primit valsartan preoperator) și un grup de cercetare (Res) (150 de pacienți care au primit sacubitril/valsartan preoperator). Leziunea miocardică, funcția cardiacă (FC), funcția renală (RF) și complicațiile celor două grupuri au fost comparate preoperator și postoperator. Rezultatele au arătat că benzile miocardice ale troponinei I și ale izoenzimei creatin kinaza în cele două loturi au prezentat o tendință de scădere postoperator, cea din grupul Res fiind mai semnificativă (p < 0,05). Postoperator, volumele telediastolic și telesistolic ale ventriculului stâng din cele două loturi de pacienți au scăzut, fiind mai semnificative în grupul Res (p < 0,05). Postoperator, porțiunea azotată a ureei din sânge și creatinina au fost scăzute în cele două loturi, tendința fiind mai evidentă în grupul Res (p < 0,05). Eficiența medicamentelor în grupul Ctrl și grupul Res a fost de 84,67%, respectiv 93,33%. În concluzie, în urma evaluării prin ultrasonografie, asocierea sacubitril/valsartan a dovedit o protecție importantă asupra inimii și rinichilor la pacienții care au suferit IPC.

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