Oral bile acid administration reduces endotoxemia and bacterial translocation (BT) in ascitic cirrhotic rats

Zuniga, Vicente Lorenzo; Bartolı́, Ramón; Planas, Ramón; Álvarez, Marco Antonio Santamaría; Viñado, Belén; Mañé, Josep; Hagey, Lee R.; Hofmann, Alan F.; Gassull, M. A.

doi:10.1016/s0168-8278(02)80728-0

Journal of Hepatology

2002

DOI: 10.1016/s0168-8278(02)80728-0

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Oral bile acid administration reduces endotoxemia and bacterial translocation (BT) in ascitic cirrhotic rats

Vicente Lorenzo Zuniga¹,

Ramón Bartolı́²,

Ramón Planas³

et al.

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Bacterial Translocation

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2005

Bioscience Microflora

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This lecture first highlights the methods available to detect bacterial translocation (BT) as well as shortcomings related to those. Secondly, mechanisms involved in the process of BT with special focus on intestinal flora, gut barrier dysfunction and the role of immune defence mechanisms are discussed. Thirdly, the potentially huge clinical relevance of BT is reviewed. BT is the key to our understanding of spontaneous bacterial peritonitis in liver cirrhosis, the multiorgan failure syndrom induced by hemorrhagic shock, burns or sepsis and is involved in a multitude of diverse gastrointestinal lesions. Therefore, BT may represent a common and so far inadequately recognized trigger for a multitude of complications known for long in various clinical entities. Finally, the focus will be to discuss advances in therapeutic approaches in preventing BT and associated potential complications. There is much evidence linking diet with the maintenance of intestinal integrity and multiple enteral manoveures have been tested. Particularly promising is the avenue of using probiotics known to exert many effects and to protect the gut from BT. Various other therapeutic approaches include binding/neutralizing of endotoxins, hyperbaric oxygen, prostaglandins, antioxidans etc. A more general attempt to reduce the presumed risk of BT is selective gut decontamination (SGD). In summary, the concept of BT contributing to morbidity is of extraordinary importance and its detailed investigation will eventually open an avenue for preventive measures against infectious complications.

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Bacterial Translocation

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2005

Bioscience Microflora

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Oral bile acid administration reduces endotoxemia and bacterial translocation (BT) in ascitic cirrhotic rats

Cited by 1 publication

References 0 publications

Bacterial Translocation

Bacterial Translocation

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