Oral calcium and blood pressure: a controlled intervention trial

Beresteyn, E. C. H. van; Schaafsma, G.; Waard, H. de

doi:10.1093/ajcn/44.6.883

Cited by 40 publications

(4 citation statements)

References 14 publications

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“…According to Basile et al (1993) increasing dietary calcium intake increases urinary calcium excretion and reduces plasma 1,25-dihydroxyvitamin D3, but total and ionized serum Ca" and plasma 25-hydroxyvitamin D3 are unchanged, as observed in the present study. The rise in 24-h urinary calcium excretion (+16-8± 1-5%) observed in the present study during oral calcium supplementation (50 mmol/day for 16 weeks) is in agreement with the increase reported in various studies (Grobbee & Hofinan 1986, Luft et al 1986, Nowson & Morgan 1986, Strazzullo et al 1986, Van Beresteyn et al 1986, Cappuccio et al 1987, Méese et al 1987, Siani et al 1988, Zoccali et al 1988, Behzan et al 1991. In these trials with a duration of 8-2 ±T3 weeks and an oral supplementation of 26-5 ± 3-6 mmol of elemental calcium per day the 24-h urinary calcium excretion increased by 17-9 ±1-6%.…”

Section: ) Actionssupporting

confidence: 92%

Effect of oral calcium supplementation on intracellular calcium and plasma renin in men

Lijnen

Petrov²

1995

Journal of Endocrinology

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A double-blind, placebo-controlled parallel study was conducted on the effect of a high daily oral calcium supplementation of 1 g elemental calcium, given twice daily for 16 weeks in normal male subjects, on plasma renin, aldosterone, kallikrein, cGMP, cAMP and calciotropic hormones, intracellular calcium concentrations and plasma total and ionized calcium. After a 1-month run-in period on a limited use of dairy products, the subjects (n = 32) were allocated to a placebo or a calcium group. Placebo or 1 g elemental calcium was administered twice daily in the morning and evening for 16 weeks. All subjects were investigated at baseline and after 1, 2, 4, 8 and 16 weeks of placebo or calcium administration. A decreased intraerythrocyte and intraplatelet Ca2+ concentration was observed in the calcium-treated subjects. Compared with the placebo group, an increase in the plasma renin activity (PRA) in the calcium group was observed after 4, 8 and 16 weeks of oral calcium administration. However, plasma aldosterone and urinary excretion of aldosterone, kallikrein, cGMP and cAMP were not changed during calcium administration. Oral calcium supplementation in these men was also accompanied by a reduction in the plasma concentration of intact parathyroid hormone and 1,25-dihydroxyvitamin D3, an increase in 24-h urinary calcium excretion but no change in the plasma total Ca2+ concentration, serum ionized Ca2+ level and plasma phosphate or 25-hydroxyvitamin D3. Lacidipine tended to increase PRA in the placebo-treated subjects and to decrease it in the calcium-treated subjects: this difference in lacidipine effect between the placebo and calcium group was significant (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: ) Actionssupporting

confidence: 92%

Effect of oral calcium supplementation on intracellular calcium and plasma renin in men

Lijnen

Petrov²

1995

Journal of Endocrinology

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“…5 Eleven studies did not conduct statistical analysis between the control and calcium group. [14][15][16][17][18][19][20][21][22][23][24] Statistical analysis of the relationship is a critical factor because it provides the comparison between, in this case, subjects consuming calcium and those not consuming calcium to determine whether there is a reduction in risk of hypertension. When statistics are not performed on the specific substance/disease relationship, it cannot be determined whether there is a difference between the two groups.…”

Section: Evaluation Of Intervention Studiesmentioning

confidence: 99%

Supplemental Calcium and Risk Reduction of Hypertension, Pregnancy-Induced Hypertension, and Preeclampsia: An Evidence-Based Review by the US Food and Drug Administration

Trumbo¹,

Ellwood²

2008

Nutrition Reviews

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The labeling of health claims that meet the significant scientific agreement (SSA) standard (authorized health claims) and qualified health claims on conventional foods and dietary supplements requires premarket approval by the US Food and Drug Administration (FDA). FDA conducts an evidence-based review to determine whether there is sufficient evidence to support an authorized or qualified health claim. An evidence-based review was conducted on the human intervention and observational studies evaluating the role of supplemental calcium in reducing the risk of hypertension, pregnancy-induced hypertension, and preeclampsia. This review provides FDA's evaluation of the current scientific evidence on the role of supplemental calcium in reducing the risk of these three end points. Based on this evidence-based review, the agency concluded that the relationship between calcium and risk of hypertension is inconsistent and inconclusive, and the relationship between calcium and risk of pregnancy-induced hypertension and preeclampsia is highly unlikely.

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“…A series of experimental reports carried out either in animals (1)(2)(3) or in human populations (4)(5)(6)(7)(8)(9) shows a clear correlation between serum concentrations of metal cations and cardiovascular diseases. The effect of dietary manipulations of mineral components on the development of atherosclerosis and related diseases suggests that the nonsaturated fatty acid metabolism is clearly influenced by its metabolic actions.…”

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confidence: 99%

Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats

Marra

Alaniz

2000

Lipids

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Fatty acid desaturase activities were determined in liver microsomes from calcium-deficient rats and compared to calcium-sufficient ones. The calcium-deprived diet (0.5 g/kg) administered for 60 d caused a 30% inhibition in the delta5 desaturase activity and a 45-55% decrease in delta6 and delta9, respectively, facts that cannot be attributed to a reduction in food intake. In vitro addition of calcium, ethyleneglycol-bis(Beta-aminoethyl ether)N,N-tetraacetic acid, and/or cytosol fractions from control or calcium-deficient rats to microsomes from both groups of animals indicates that the reduced desaturase capacities would be the consequence of an indirect effect of calcium deprivation. The present work shows that the reduced unsaturated fatty acid biosynthesis might be the result of modifications in the physicochemical properties of microsomal membranes. Such changes could also be derived from the inhibition of phospholipase A2 activity induced by calcium deficiency.

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Oral calcium and blood pressure: a controlled intervention trial

Cited by 40 publications

References 14 publications

Effect of oral calcium supplementation on intracellular calcium and plasma renin in men

Effect of oral calcium supplementation on intracellular calcium and plasma renin in men

Supplemental Calcium and Risk Reduction of Hypertension, Pregnancy-Induced Hypertension, and Preeclampsia: An Evidence-Based Review by the US Food and Drug Administration

Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats

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