Oral calcium inhibits rectal epithelial proliferation in familial adenomatous polyposis

Thomas, M. G.; Thomson, J. P. S.; Williamson, R. C. N.

doi:10.1002/bjs.1800800432

Cited by 37 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cultured tissue showed a good preservation of architecture with an infection and crypt necrosis rate of 2%, in line with our previous results.15 21 There was no evidence of metaphase escape in any of the microdissected crypts, which implies that the dose of vincristine used was sufficient to produce complete metaphase arrest. In addition the crypts appeared intact.…”

Section: Resultssupporting

confidence: 88%

Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis.

Thomas

Nugent

Forbes

et al. 1994

Gut

Self Cite

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 88%

Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis.

Thomas

Nugent

Forbes

et al. 1994

Gut

Self Cite

View full text Add to dashboard Cite

“…95 This singlecentre study randomised 28 participants, recruiting people with FAP (median age 38 years; range 16 to 65) who had previously undergone total abdominal colectomy with ileorectal anastomosis who were under surveillance for rectal polyps. Subjects in the intervention arm were given calcium carbonate (1500 mg daily) for a 6-month period.…”

Section: Study and Population Characteristicsmentioning

confidence: 99%

Chemoprevention of colorectal cancer: systematic review and economic evaluation

Cooper

Squires²,

Carroll³

et al. 2010

Health Technol Assess

184

182

View full text Add to dashboard Cite

How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of project...

show abstract

“…2 Epidemiological studies and diet histories have reported an inverse association between dietary calcium intake and the incidence of colorectal cancer. [3][4][5][6] In vitro studies of colon cancer cell lines, 7 studies in experimental animals, [8][9][10][11] and intervention trials in humans [12][13][14] also support the concept that dietary calcium supplementation reduces the risk of subsequent colorectal cancer development, although negative studies have also been reported. [15][16][17] Chemoprevention of colorectal cancer with calcium is attractive because it is safe, nontoxic, cheap, and seems acceptable to patients.…”

mentioning

confidence: 89%

Dietary calcium supplementation increases apoptosis in the distal murine colonic epithelium

Penman

Liang²,

Bode³

et al. 2000

J Clin Pathol

View full text Add to dashboard Cite

Background-Increased dietary calcium might reduce colorectal cancer risk, possibly by reduction of colonic epithelial hyperproliferation, but not all studies have demonstrated this. Little is known about the eVects of calcium on colonic apoptosis. Aim-To quantify the eVects of increasing calcium on apoptosis and cell proliferation in normal murine colonic crypt epithelium. Methods-Twenty one day old male C57Bl/6 mice were fed either control AIN-76 diet (0.5% calcium wt/wt; n = 10) or the same supplemented with calcium carbonate (1.0% calcium; n = 10) for 12 weeks. Apoptotic cells in proximal and distal segments were counted and expressed as an apoptotic index (AI: frequency of apoptosis/100 longitudinal crypts). The bromodeoxyuridine (BrdU) labelling index was also determined. DiVerences were analysed by the student's t test. Results-In control animals, the AI was significantly higher in the caecum/ proximal colon (mean, 28.6; SEM, 2.0) compared with the distal colon (mean, 19.9; SEM, 1.8; p = 0.004). In the calcium treated group, the AI in the caecum/ proximal colon (mean, 30.6; SEM, 1.7) was similar to controls (p = 0.71) but the AI in the distal colon was significantly greater (mean, 32.6; SEM, 1.8; p = 0.001) than in control mice and was raised to values similar to those in the proximal colon. Calcium was also associated with reduced crypt cellularity and, in the proximal colon, a downward shift in the crypt position at which apoptosis occurred. There were no significant diVerences in the BrdU labelling index between groups or between proximal and distal colonic segments in each group. Conclusions-Increased dietary calcium is associated with the induction of apoptosis in normal mouse distal colonic epithelium without aVecting cell proliferation. This might contribute to its putative chemopreventive role in colorectal carcinogenesis. Whether this eVect is direct or indirect requires further study. (J Clin Pathol 2000;53:302-307)

show abstract

Oral calcium inhibits rectal epithelial proliferation in familial adenomatous polyposis

Cited by 37 publications

References 26 publications

Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis.

Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis.

Chemoprevention of colorectal cancer: systematic review and economic evaluation

Dietary calcium supplementation increases apoptosis in the distal murine colonic epithelium

Contact Info

Product

Resources

About