Oral cancer associated with chronic mechanical irritation of the oral mucosa

Piemonte, Eduardo; Lazos, Jerónimo; Belardinelli, Paola; Secchi, Dante Gustavo; Brunotto, Mabel; Lanfranchi-Tizeira, H

doi:10.4317/medoral.22017

Cited by 38 publications

(45 citation statements)

References 29 publications

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“…Repeated exposure to carcinogens (including tobacco and alcohol), irritation of the oral mucosa (especially tongue epithelium) due to the presence of tooth decay, or mechanical stimulation by ill-fitting dentures are the main causes of human OSCC (1,24). These events may also directly activate YAP1 or induce oncogenic mutations in the abovementioned genes that activate YAP1.…”

Section: Discussionmentioning

confidence: 99%

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma

et al. 2020

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Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common group of cancers in the world, and patients have a poor prognosis. Here, we present data indicating that YAP1 may be a strong driver of the onset and progression of oral SCC (OSCC), a major subtype of HNSCC. Mice with tongue-specific deletion of Mob1a/b and thus endogenous YAP1 hyperactivation underwent surprisingly rapid and highly reproducible tumorigenesis, developing tongue carcinoma in situ within 2 weeks and invasive SCC within 4 weeks. In humans, precancerous tongue dysplasia displays YAP1 activation correlating with reduced patient survival. Combinations of molecules mutated in OSCC may increase and sustain YAP1 activation to the point of oncogenicity. Strikingly, siRNA or pharmacological inhibition of YAP1 blocks murine OSCC onset in vitro and in vivo. Our work justifies targeting YAP1 as therapy for OSCC and perhaps HNSCC, and our mouse model represents a powerful tool for evaluating these agents.

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Section: Discussionmentioning

confidence: 99%

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma

et al. 2020

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“…The increase of cell proliferation due to CMI was previously proposed as a predisposing event in a multistep model of oral carcinogenesis ( 5 ). NHCTU would meet those requirements and could act as a promoter cofactor in malignant transformation ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers

Gilligan¹,

Panico²,

Tada³

et al. 2020

Med Oral

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Background Chronic wounds were previously related to cancer. Chronic Traumatic Ulcers (CTU) are lesions caused by chronic mechanical irritation (CMI) frequently diagnosed in Oral Medicine. Although these conditions may reflect a benign nature, some authors have proposed its relationship with malignant transformation. Currently, there are scarce investigations that evaluate biomarkers within CTU. The aim of this study was to evaluate cell differentiation and proliferation biomarkers patterns of CTU and OSCC through recognized markers such as cytokeratin 19 and Ki67 and correlate it with clinical features of both groups of patients. Material and Methods A Cross-sectional study of adult patients (n=79), both sexes, attended at Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba. The patients were classified into two groups: CTU (n=41), and OSCC (n=38). A subset of specimens were immunolabeled with Ki67 and Ck19. Results The population consisted of 51.9% male and 48.1% female, with an average of 57.0 ± 13.9. years (OSCC group) and 60.9 ± 14.9 years (CTU group). OSCC group presented higher scores for both biomarkers (Ki67 and Ck19), but only there were differences statistically significant for Ki67 ( p =0.032). 25% of non-healing CTU were positive with medium scores of Ck19 and showed an immunohistochemical profile similar to OSCC. The lateral tongue was the most frequent site in both groups. Conclusions The altered immunohistochemical pattern found in many specimens of CTU was also observed in OSCC. The tongue border presents physiological conditions that could offer a suitable environment for the development of neoplastic events associated with CMI. Further studies are needed to understand the underlying mechanisms that could link oral non-healing ulcers with early malignant changes. Key words: Ck19, Ki67, Oral Cancer, Chronic Traumatic Ulcer, Chronic Mechanical Irritation.

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“…Regarding hospitals and treatment delays, although oncologic surgical procedures should be avoided during the pandemic, there is no convincing evidence that cancer therapies are contraindicated 6 . In a study performed in our institution before the pandemic, 60% of all OC were either Tis, T1, or T2 7 . Therefore, the pandemic could have affected tumor staging at the first visit and cause management postponement.…”

Section: Figurementioning

confidence: 99%

Delays in the diagnosis of oral cancer due to the quarantine of COVID‐19 in Córdoba, Argentina

Gilligan

Lazos

Piemonte

et al. 2020

Special Care in Dentistry

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Oral cancer associated with chronic mechanical irritation of the oral mucosa

Cited by 38 publications

References 29 publications

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma

Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers

Delays in the diagnosis of oral cancer due to the quarantine of COVID‐19 in Córdoba, Argentina

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